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citE-2 citE-2 sucC sucC sucD sucD ilvB ilvB ilvH ilvH leuB leuB leuC leuC leuD leuD AIJ22298.1 AIJ22298.1 ttuC ttuC leuB-2 leuB-2 AIJ22917.1 AIJ22917.1 menG menG AIJ24297.1 AIJ24297.1 ilvB-4 ilvB-4 AIJ26802.1 AIJ26802.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
citE-2HpcH/HpaI aldolase; Belongs to the HpcH/HpaI aldolase family. (356 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa)
ilvBAcetolactate synthase I/II/III large subunit. (581 aa)
ilvHAcetolactate synthase, small subunit. (153 aa)
leuBTartrate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (347 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (471 aa)
leuD3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa)
AIJ22298.1Dimethylmenaquinone methyltransferase. (235 aa)
ttuC3-isopropylmalate dehydrogenase. (358 aa)
leuB-23-isopropylmalate dehydrogenase. (383 aa)
AIJ22917.1Dimethylmenaquinone methyltransferase. (229 aa)
menGPutative methyltransferase. (118 aa)
AIJ24297.1Aconitate hydratase. (277 aa)
ilvB-4Acetolactate synthase I/II/III large subunit. (517 aa)
AIJ26802.1Hypothetical protein; Belongs to the TPP enzyme family. (566 aa)
Your Current Organism:
Amycolatopsis methanolica
NCBI taxonomy Id: 1068978
Other names: A. methanolica 239, Amycolatopsis methanolica 239, Amycolatopsis methanolica IFO 15065, Amycolatopsis methanolica IMSNU 20055, Amycolatopsis methanolica KCTC 9411, Amycolatopsis methanolica NCIB 11946, Amycolatopsis methanolica NRRL B-24139, Amycolatopsis methanolica str. 239, Amycolatopsis methanolica strain 239
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