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coaA coaA AIJ20930.1 AIJ20930.1 panB panB ilvD-2 ilvD-2 ilvB ilvB ilvH ilvH ilvC ilvC coaD coaD pydB pydB AIJ22009.1 AIJ22009.1 coaE coaE AIJ23267.1 AIJ23267.1 AIJ23288.1 AIJ23288.1 betB-6 betB-6 ilvD-3 ilvD-3 ilvD-4 ilvD-4 feaB feaB dfp dfp apbA apbA AIJ24655.1 AIJ24655.1 ilvC-2 ilvC-2 ilvE ilvE ilvB-4 ilvB-4 AIJ26288.1 AIJ26288.1 ilvD-5 ilvD-5 coaX coaX panD panD panC panC AIJ26802.1 AIJ26802.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
coaAPantothenate kinase. (310 aa)
AIJ20930.1Betaine aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (477 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (286 aa)
ilvD-2Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (614 aa)
ilvBAcetolactate synthase I/II/III large subunit. (581 aa)
ilvHAcetolactate synthase, small subunit. (153 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)
pydBDihydropyrimidinase. (461 aa)
AIJ22009.1N-carbamoylputrescine amidase. (280 aa)
coaEdephospho-CoA kinase/protein folding accessory domain-containing protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (394 aa)
AIJ23267.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (483 aa)
AIJ23288.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (478 aa)
betB-6Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (500 aa)
ilvD-3Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (548 aa)
ilvD-4Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (394 aa)
feaBAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (485 aa)
dfpPhosphopantothenoylcysteine decarboxylase/phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa)
apbAKetopantoate reductase ApbA/PanE domain protein. (328 aa)
AIJ24655.1Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (461 aa)
ilvC-2Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
ilvEBranched-chain amino acid aminotransferase. (363 aa)
ilvB-4Acetolactate synthase I/II/III large subunit. (517 aa)
AIJ26288.14-phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily. (233 aa)
ilvD-5Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (558 aa)
coaXTranscriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (261 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (165 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (294 aa)
AIJ26802.1Hypothetical protein; Belongs to the TPP enzyme family. (566 aa)
Your Current Organism:
Amycolatopsis methanolica
NCBI taxonomy Id: 1068978
Other names: A. methanolica 239, Amycolatopsis methanolica 239, Amycolatopsis methanolica IFO 15065, Amycolatopsis methanolica IMSNU 20055, Amycolatopsis methanolica KCTC 9411, Amycolatopsis methanolica NCIB 11946, Amycolatopsis methanolica NRRL B-24139, Amycolatopsis methanolica str. 239, Amycolatopsis methanolica strain 239
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