(23 nodes) Terpenoid backbone biosynthesis network (Kazachstania naganishii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Your Input:
	KNAG0J00310	Uncharacterized protein. (317 aa)
	KNAG0A05770	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (433 aa)
	KNAG0B06690	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1038 aa)
	KNAG0A02340	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
	KNAG0C04460	Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (239 aa)
	KNAG0H01540	Nudix hydrolase domain-containing protein. (291 aa)
	KNAG0J01170	Alkyl transferase; Belongs to the UPP synthase family. (307 aa)
	KNAG0D01150	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (460 aa)
	KNAG0E02410	Alkyl transferase; Belongs to the UPP synthase family. (344 aa)
	KNAG0E04090	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1087 aa)
	KNAG0A02000	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (334 aa)
	KNAG0H03530	Uncharacterized protein. (614 aa)
	KNAG0J01960	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (419 aa)
	KNAG0J02060	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (455 aa)
	KNAG0B02820	Uncharacterized protein. (360 aa)
	KNAG0C01010	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (352 aa)
	KNAG0B00520	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (723 aa)
	KNAG0C06510	Peptidase_M48 domain-containing protein. (366 aa)
	KNAG0D00260	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (397 aa)
	KNAG0H00200	Uncharacterized protein. (317 aa)
	KNAG0J00160	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (449 aa)
	KNAG0J01180	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (473 aa)
	KNAG0J00280	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (742 aa)

Your Current Organism:

Kazachstania naganishii

NCBI taxonomy Id: 1071383
Other names: K. naganishii CBS 8797, Kazachstania naganishii CBS 8797

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KNAG0A02000	KNAG0A02340	J7S1Y4	J7REE0	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.547
KNAG0A02000	KNAG0A05770	J7S1Y4	J7R0B4	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.883
KNAG0A02000	KNAG0B02820	J7S1Y4	J7S3H0	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.826
KNAG0A02000	KNAG0B06690	J7S1Y4	J7R2P9	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.484
KNAG0A02000	KNAG0C01010	J7S1Y4	J7S4B8	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.938
KNAG0A02000	KNAG0D00260	J7S1Y4	J7S5C5	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.935
KNAG0A02000	KNAG0E02410	J7S1Y4	J7RZ87	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Alkyl transferase; Belongs to the UPP synthase family.	0.840
KNAG0A02000	KNAG0E04090	J7S1Y4	J7RZL2	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.484
KNAG0A02000	KNAG0H00200	J7S1Y4	J7S9C2	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.891
KNAG0A02000	KNAG0H01540	J7S1Y4	J7RPF4	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Nudix hydrolase domain-containing protein.	0.917
KNAG0A02000	KNAG0J00160	J7S1Y4	J7S9G6	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.742
KNAG0A02000	KNAG0J01170	J7S1Y4	J7RQU8	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Alkyl transferase; Belongs to the UPP synthase family.	0.858
KNAG0A02000	KNAG0J01180	J7S1Y4	J7S9M9	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.899
KNAG0A02000	KNAG0J01960	J7S1Y4	J7S2W4	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.626
KNAG0A02000	KNAG0J02060	J7S1Y4	J7S2X1	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.516
KNAG0A02340	KNAG0A02000	J7REE0	J7S1Y4	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.547
KNAG0A02340	KNAG0B06690	J7REE0	J7R2P9	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.456
KNAG0A02340	KNAG0C01010	J7REE0	J7S4B8	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.637
KNAG0A02340	KNAG0D00260	J7REE0	J7S5C5	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.789
KNAG0A02340	KNAG0E04090	J7REE0	J7RZL2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.456