STRINGSTRING
gabD gabD AIL32022.1 AIL32022.1 AIL32023.1 AIL32023.1 AIL32024.1 AIL32024.1 prpB prpB AIL32134.1 AIL32134.1 AIL32135.1 AIL32135.1 AIL32146.1 AIL32146.1 mdh mdh AIL32206.1 AIL32206.1 AIL32207.1 AIL32207.1 AIL32208.1 AIL32208.1 sdhB sdhB gltA gltA AIL32217.1 AIL32217.1 sucA sucA AIL32244.1 AIL32244.1 AIL32245.1 AIL32245.1 AIL32301.1 AIL32301.1 AIL32302.1 AIL32302.1 AIL32303.1 AIL32303.1 AIL32304.1 AIL32304.1 AIL32332.1 AIL32332.1 AIL32524.1 AIL32524.1 AIL32578.1 AIL32578.1 AIL32597.1 AIL32597.1 aceE aceE AIL32619.1 AIL32619.1 AIL32648.1 AIL32648.1 sucD sucD sucC sucC fumC fumC AIL33019.1 AIL33019.1 glcB glcB AIL33130.1 AIL33130.1 AIL33155.1 AIL33155.1 AIL33209.1 AIL33209.1 AIL33311.1 AIL33311.1 gltD gltD AIL33333.1 AIL33333.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gabDSuccinate-semialdehyde dehydrogenase; Catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
AIL32022.13-methylitaconate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
AIL32023.1Aconitate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (866 aa)
AIL32024.1Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
prpB2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (288 aa)
AIL32134.1LamB/YcsF family protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. (245 aa)
AIL32135.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
AIL32146.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (497 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (327 aa)
AIL32206.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (141 aa)
AIL32207.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (125 aa)
AIL32208.1Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (593 aa)
sdhBPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (436 aa)
AIL32217.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (759 aa)
sucASucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. (953 aa)
AIL32244.1Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (403 aa)
AIL32245.1E3 component of 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
AIL32301.1Proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1198 aa)
AIL32302.1Proline:sodium symporter PutP; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (490 aa)
AIL32303.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (61 aa)
AIL32304.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (530 aa)
AIL32332.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (444 aa)
AIL32524.1Converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (449 aa)
AIL32578.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (492 aa)
AIL32597.1CDP-6-deoxy-delta-3,4-glucoseen reductase; Catalyzes the formation of 3,6-dideoxy-D-glycero-D-glycero-4-hexulose; Derived by automated computational analysis using gene prediction method: Protein Homology. (340 aa)
aceEPyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (894 aa)
AIL32619.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (581 aa)
AIL32648.1Glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (428 aa)
sucDsuccinate--CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa)
AIL33019.1acetyl-CoA hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (507 aa)
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (722 aa)
AIL33130.1Isocitrate lyase; Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; Derived by automated computational analysis using gene prediction method: Protein Homology. (533 aa)
AIL33155.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
AIL33209.1Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aconitase/IPM isomerase family. (861 aa)
AIL33311.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
gltDGlutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (488 aa)
AIL33333.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1560 aa)
Your Current Organism:
Basilea psittacipulmonis
NCBI taxonomy Id: 1072685
Other names: Alcaligenaceae bacterium CIP 110308, Alcaligenaceae bacterium DSM 24701, B. psittacipulmonis DSM 24701, Basilea psittacipulmonis CIP 110308, Basilea psittacipulmonis DSM 24701
Server load: low (20%) [HD]