(25 nodes) Mixed, incl. RNA polymerase complex, and Sigma-70 factor, region 1.2 network (Streptomyces sp. HGB0020)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EPD69575.1	Hypothetical protein. (283 aa)
	EPD66682.1	Hypothetical protein. (722 aa)
	whiB-2	Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (103 aa)
	sigA	RNA polymerase principal sigma factor hrdB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (562 aa)
	EPD65716.1	Hypothetical protein. (658 aa)
	EPD62229.1	Hypothetical protein. (984 aa)
	EPD62230.1	Hypothetical protein. (427 aa)
	rbpA	Hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. (124 aa)
	rpoZ	DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (90 aa)
	EPD61294.1	Hypothetical protein. (186 aa)
	EPD61447.1	Hypothetical protein. (275 aa)
	rpoB	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1161 aa)
	rpoC	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1299 aa)
	EPD60770.1	Hypothetical protein. (539 aa)
	EPD59741.1	Hypothetical protein; Belongs to the Fur family. (139 aa)
	EPD58962.1	RNA polymerase sigma factor rpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (442 aa)
	EPD58007.1	Hypothetical protein. (416 aa)
	EPD56877.1	RNA polymerase principal sigma factor hrdD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (332 aa)
	EPD57124.1	Hypothetical protein. (160 aa)
	rpoA-2	DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (338 aa)
	EPD55486.1	DNA-directed RNA polymerase subunit alpha. (39 aa)
	whiB-10	Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (122 aa)
	EPD54739.1	Hypothetical protein. (1549 aa)
	EPD54803.1	Hypothetical protein. (600 aa)
	EPD54482.1	Hypothetical protein. (740 aa)

Your Current Organism:

Streptomyces sp. HGB0020

NCBI taxonomy Id: 1078086
Other names: S. sp. HGB0020

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EPD54482.1	EPD55486.1	HMPREF1211_08427	HMPREF1211_07913	Hypothetical protein.	DNA-directed RNA polymerase subunit alpha.	0.758
EPD54482.1	rpoA-2	HMPREF1211_08427	HMPREF1211_07032	Hypothetical protein.	DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.763
EPD54482.1	rpoB	HMPREF1211_08427	HMPREF1211_04676	Hypothetical protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.922
EPD54482.1	rpoC	HMPREF1211_08427	HMPREF1211_04677	Hypothetical protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.915
EPD54482.1	rpoZ	HMPREF1211_08427	HMPREF1211_04265	Hypothetical protein.	DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.926
EPD54482.1	whiB-2	HMPREF1211_08427	HMPREF1211_00973	Hypothetical protein.	Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.	0.544
EPD54739.1	EPD55486.1	HMPREF1211_08272	HMPREF1211_07913	Hypothetical protein.	DNA-directed RNA polymerase subunit alpha.	0.966
EPD54739.1	EPD58007.1	HMPREF1211_08272	HMPREF1211_06345	Hypothetical protein.	Hypothetical protein.	0.600
EPD54739.1	EPD60770.1	HMPREF1211_08272	HMPREF1211_04788	Hypothetical protein.	Hypothetical protein.	0.943
EPD54739.1	EPD61294.1	HMPREF1211_08272	HMPREF1211_04319	Hypothetical protein.	Hypothetical protein.	0.692
EPD54739.1	EPD62229.1	HMPREF1211_08272	HMPREF1211_03863	Hypothetical protein.	Hypothetical protein.	0.790
EPD54739.1	EPD65716.1	HMPREF1211_08272	HMPREF1211_02271	Hypothetical protein.	Hypothetical protein.	0.990
EPD54739.1	rpoA-2	HMPREF1211_08272	HMPREF1211_07032	Hypothetical protein.	DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.966
EPD54739.1	rpoB	HMPREF1211_08272	HMPREF1211_04676	Hypothetical protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.979
EPD54739.1	rpoC	HMPREF1211_08272	HMPREF1211_04677	Hypothetical protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.822
EPD54739.1	rpoZ	HMPREF1211_08272	HMPREF1211_04265	Hypothetical protein.	DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.	0.988
EPD54803.1	EPD55486.1	HMPREF1211_08337	HMPREF1211_07913	Hypothetical protein.	DNA-directed RNA polymerase subunit alpha.	0.987
EPD54803.1	EPD58007.1	HMPREF1211_08337	HMPREF1211_06345	Hypothetical protein.	Hypothetical protein.	0.600
EPD54803.1	EPD60770.1	HMPREF1211_08337	HMPREF1211_04788	Hypothetical protein.	Hypothetical protein.	0.943
EPD54803.1	EPD61294.1	HMPREF1211_08337	HMPREF1211_04319	Hypothetical protein.	Hypothetical protein.	0.692