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sfcA sfcA GNIT_0596 GNIT_0596 GNIT_0627 GNIT_0627 acnB acnB mdh mdh glcB glcB GNIT_0993 GNIT_0993 bkdB bkdB bkdA2 bkdA2 bkdA1 bkdA1 fumA fumA mmsA mmsA sucD sucD sucC sucC GNIT_2028 GNIT_2028 GNIT_2029 GNIT_2029 sdhB sdhB sdhA sdhA sdhD sdhD sdhC sdhC GNIT_2034 GNIT_2034 GNIT_2625 GNIT_2625 fumC fumC GNIT_2671 GNIT_2671 GNIT_2672 GNIT_2672 aceE aceE acsA acsA GNIT_2866 GNIT_2866 GNIT_2867 GNIT_2867 GNIT_2868 GNIT_2868 GNIT_2869 GNIT_2869 GNIT_3249 GNIT_3249 prpE prpE GNIT_3412 GNIT_3412 ackA ackA GNIT_3429 GNIT_3429 GNIT_3512 GNIT_3512
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sfcAMalate dehydrogenase. (564 aa)
GNIT_0596Glycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa)
GNIT_0627NAD-dependent aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (469 aa)
acnBBifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Belongs to the aconitase/IPM isomerase family. (870 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (750 aa)
GNIT_0993Isocitrate lyase. (533 aa)
bkdBDihydrolipoamide acetyltransferase. (564 aa)
bkdA22-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (325 aa)
bkdA13-methyl-2-oxobutanoate dehydrogenase (lipoamide). (395 aa)
fumAFumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (510 aa)
mmsAMethylmalonate-semialdehyde dehydrogenase. (496 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
GNIT_2028Dihydrolipoyltranssuccinate transferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (500 aa)
GNIT_20292-oxoglutarate decarboxylase. (942 aa)
sdhBSuccinate dehydrogenase catalytic subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (236 aa)
sdhASuccinate dehydrogenase catalytic subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (590 aa)
sdhDPutative succinate dehydrogenase, hydrophobic subunit, cytochrome b556 with sdhC; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
sdhCSuccinate dehydrogenase, cytochrome b subunit. (92 aa)
GNIT_2034Citrate synthase; Belongs to the citrate synthase family. (426 aa)
GNIT_2625Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (903 aa)
fumCFumarate hydratase. (435 aa)
GNIT_2671Dihydrolipoamide dehydrogenase. (472 aa)
GNIT_2672Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (592 aa)
aceEPyruvate dehydrogenase (decarboxylase component, E1); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (890 aa)
acsAAcetyl-coenzyme A synthetase (Acetate--CoA ligase) (Acyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (647 aa)
GNIT_2866Catalytic domain of components of various dehydrogenase complexes. (423 aa)
GNIT_2867Pyruvate dehydrogenase complex, E1 beta2 component; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (331 aa)
GNIT_2868Pyruvate dehydrogenase (acetyl-transferring). (272 aa)
GNIT_2869acetyl-CoA synthetase. (583 aa)
GNIT_3249Putative dehydrogenase, NAD(P)-binding domain and GroES-like domain protein. (328 aa)
prpEpropionyl-CoA synthetase. (634 aa)
GNIT_3412Bifunctional enoyl-CoA hydratase/phosphate acetyltransferase. (470 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (395 aa)
GNIT_3429Citrate synthase. (264 aa)
GNIT_3512Malate synthase G. (334 aa)
Your Current Organism:
Glaciecola nitratireducens
NCBI taxonomy Id: 1085623
Other names: G. nitratireducens FR1064, Glaciecola nitratireducens FR1064, Glaciecola nitratireducens str. FR1064, Glaciecola nitratireducens strain FR1064, Glaciecola sp. FR1064
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