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sfcA sfcA acnB acnB mdh mdh fumA fumA sucD sucD sucC sucC GNIT_2028 GNIT_2028 GNIT_2029 GNIT_2029 sdhB sdhB sdhA sdhA sdhD sdhD sdhC sdhC GNIT_2034 GNIT_2034 GNIT_2625 GNIT_2625 fumC fumC GNIT_3429 GNIT_3429
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
sfcAMalate dehydrogenase. (564 aa)
acnBBifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Belongs to the aconitase/IPM isomerase family. (870 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (312 aa)
fumAFumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (510 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
GNIT_2028Dihydrolipoyltranssuccinate transferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (500 aa)
GNIT_20292-oxoglutarate decarboxylase. (942 aa)
sdhBSuccinate dehydrogenase catalytic subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (236 aa)
sdhASuccinate dehydrogenase catalytic subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (590 aa)
sdhDPutative succinate dehydrogenase, hydrophobic subunit, cytochrome b556 with sdhC; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa)
sdhCSuccinate dehydrogenase, cytochrome b subunit. (92 aa)
GNIT_2034Citrate synthase; Belongs to the citrate synthase family. (426 aa)
GNIT_2625Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (903 aa)
fumCFumarate hydratase. (435 aa)
GNIT_3429Citrate synthase. (264 aa)
Your Current Organism:
Glaciecola nitratireducens
NCBI taxonomy Id: 1085623
Other names: G. nitratireducens FR1064, Glaciecola nitratireducens FR1064, Glaciecola nitratireducens str. FR1064, Glaciecola nitratireducens strain FR1064, Glaciecola sp. FR1064
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