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| | coaBC | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (421 aa) |
| | mutM | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (270 aa) |
| | ubiC | Putative chorismate pyruvate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (196 aa) |
| | paaG | enoyl-CoA hydratase. (287 aa) |
| | fadN | Fatty oxidation complex, alpha subunit; Belongs to the enoyl-CoA hydratase/isomerase family. (702 aa) |
| | GNIT_0188 | Haloalkane dehalogenase. (301 aa) |
| | hemX | uroporphyrin-III C-methyltransferase. (398 aa) |
| | hemD | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (249 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (167 aa) |
| | nei | Endonuclease VIII. (274 aa) |
| | GNIT_0283 | Dimethylmenaquinone methyltransferase. (206 aa) |
| | lysA | Putative diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (416 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (349 aa) |
| | GNIT_0436 | Adenylate/guanylate cyclase. (346 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (357 aa) |
| | sfcA | Malate dehydrogenase. (564 aa) |
| | argH | Argininosuccinate lyase. (461 aa) |
| | mgsA | Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (138 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (336 aa) |
| | paaG-2 | enoyl-CoA hydratase/isomerase. (283 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (381 aa) |
| | murQ | Glucokinase regulatory-like protein; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. (306 aa) |
| | acnB | Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Belongs to the aconitase/IPM isomerase family. (870 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (869 aa) |
| | GNIT_0834 | Pyridoxal-dependent decarboxylase. (468 aa) |
| | cobD | Cobalamin biosynthesis protein CbiB. (332 aa) |
| | GNIT_0928 | Uncharacterized protein involved in cation transport; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (195 aa) |
| | leuD | Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (199 aa) |
| | leuC | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa) |
| | GNIT_0993 | Isocitrate lyase. (533 aa) |
| | GNIT_0996 | Putative secreted hydrolase. (462 aa) |
| | ribA-2 | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (368 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (262 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (233 aa) |
| | hisB | Imidazole glycerol-phosphate dehydratase/histidinol phosphatase; In the N-terminal section; belongs to the histidinol- phosphatase family. (356 aa) |
| | fadJ | Multifunctional fatty acid oxidation complex subunit alpha; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities. Belongs to the enoyl-CoA hydratase/isomerase family. In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (702 aa) |
| | GNIT_1225 | Chorismate mutase/prephenate dehydratase. (393 aa) |
| | sufS | Selenocysteine lyase/Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (405 aa) |
| | pycB | Pyruvate carboxylase subunit B. (681 aa) |
| | GNIT_1421 | D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase. (121 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa) |
| | trpB | Tryptophan synthase, beta protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (393 aa) |
| | trpCF | Bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Belongs to the TrpC family. (472 aa) |
| | fadN-2 | 3-hydroxyacyl-CoA dehydrogenase, NAD-binding protein. (704 aa) |
| | GNIT_1563 | Alpha/beta hydrolase fold protein. (336 aa) |
| | GNIT_1577 | Pterin-4a-carbinolamine dehydratase. (100 aa) |
| | GNIT_1586 | Threonine aldolase. (337 aa) |
| | GNIT_1648 | Putative threonine aldolase. (343 aa) |
| | sufS-2 | SufS subfamily cysteine desulfurase. (606 aa) |
| | GNIT_1695 | Pyruvate carboxyltransferase. (299 aa) |
| | liuC | enoyl-CoA hydratase/isomerase. (264 aa) |
| | pabC | 4-amino-4-deoxychorismate lyase. (294 aa) |
| | mltG | Hypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (367 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (240 aa) |
| | GNIT_1840 | Alpha/beta fold family hydrolase. (316 aa) |
| | GNIT_1870 | Deoxyribodipyrimidine photolyase-related protein. (512 aa) |
| | phrB | DNA photolyase. (481 aa) |
| | phrB-2 | Deoxyribodipyrimidine photolyase; Belongs to the DNA photolyase family. (434 aa) |
| | phrB-3 | Deoxyribodipyrimidine photolyase; Belongs to the DNA photolyase family. (481 aa) |
| | fabA | 3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (175 aa) |
| | fumA | Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (510 aa) |
| | sdaA | L-serine dehydratase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family. (457 aa) |
| | cynT | Putative carbonic anhydrase. (193 aa) |
| | GNIT_1988 | Hypothetical protein. (296 aa) |
| | rlpA | Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (317 aa) |
| | eda | Keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase. (211 aa) |
| | edd | Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (609 aa) |
| | GNIT_2131 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (458 aa) |
| | GNIT_2132 | PAS fold family. (414 aa) |
| | queE | Radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (224 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (219 aa) |
| | GNIT_2263 | Endonuclease III. (51 aa) |
| | GNIT_2264 | Lactoylglutathione lyase. (127 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa) |
| | oadB | Oxaloacetate decarboxylase, beta subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the GcdB/MmdB/OadB family. (376 aa) |
| | oadA | Oxaloacetate decarboxylase. (593 aa) |
| | oadG | Putative oxaloacetate decarboxylase subunit gamma; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation. (94 aa) |
| | aroB-2 | 3-dehydroquinate synthase. (355 aa) |
| | mltF | Lytic transglycosylase, catalytic; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. (455 aa) |
| | fabZ | (3R)-hydroxymyristol acyl carrier protein dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (148 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (433 aa) |
| | rfbB | dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (353 aa) |
| | GNIT_2554 | Hypothetical protein. (800 aa) |
| | GNIT_2602 | Hypothetical protein. (137 aa) |
| | GNIT_2625 | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (903 aa) |
| | fumC | Fumarate hydratase. (435 aa) |
| | GNIT_2727 | Fructose-1,6-bisphosphate aldolase. (299 aa) |
| | GNIT_2755 | Threonine synthase. (427 aa) |
| | GNIT_2769 | D-cysteine desulfhydrase, PLP-dependent enzyme. (371 aa) |
| | nspC | Carboxynorspermidine decarboxylase; Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine; Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily. (379 aa) |
| | folB | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (117 aa) |
| | GNIT_2832 | Methionine gamma-lyase. (422 aa) |
| | GNIT_2835 | Regulatory protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (155 aa) |
| | GNIT_2873 | Hypothetical protein. (214 aa) |
| | cysG | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (467 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (159 aa) |
| | fadB | Multifunctional fatty acid oxidation complex subunit alpha; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (719 aa) |
| | GNIT_2949 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (180 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (272 aa) |
| | gadB | Glutamate decarboxylase putative. (540 aa) |
| | GNIT_3037 | Glyoxalase/Bleomycin resistance /Dioxygenase superfamily protein. (123 aa) |
| | rfbB-2 | dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (355 aa) |
| | hemH | Protoheme ferro-lyase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (363 aa) |
| | nnrE | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] (499 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (354 aa) |
| | prpB | 2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (292 aa) |
| | GNIT_3156 | Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (862 aa) |
| | GNIT_3182 | hydroxymethylglutaryl-CoA lyase. (304 aa) |
| | leuD-2 | Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (199 aa) |
| | leuC-2 | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (537 aa) |
| | moaA-2 | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (349 aa) |
| | speA | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. (641 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (559 aa) |
| | prpD | 2-methylcitrate dehydratase. (495 aa) |
| | GNIT_3426 | 3-isopropylmalate dehydratase, putative; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (194 aa) |
| | leuC-3 | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (459 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (152 aa) |
| | ilvD-2 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (615 aa) |
| | cynT-2 | Beta-carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (214 aa) |
