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| | fadH | 2,4-dienoyl-CoA reductase. (675 aa) |
| | GNIT_0230 | Beta-ketothiolase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | GNIT_0186 | AMP-dependent synthetase and ligase. (717 aa) |
| | GNIT_0174 | Acyltransferase family protein. (203 aa) |
| | GNIT_0170 | MaoC domain-containing protein. (146 aa) |
| | fadN | Fatty oxidation complex, alpha subunit; Belongs to the enoyl-CoA hydratase/isomerase family. (702 aa) |
| | GNIT_0113 | acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (399 aa) |
| | paaG | enoyl-CoA hydratase. (287 aa) |
| | pip | Proline iminopeptidase. (318 aa) |
| | GNIT_0089 | Putative phosphatidyl transferase, inner membrane protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (214 aa) |
| | opsX | Putative ADP-heptose:LPS heptosyltransferase. (348 aa) |
| | kdkA | 3-deoxy-D-manno-octulosonic-acid kinase; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position; Belongs to the protein kinase superfamily. KdkA/RfaP family. (280 aa) |
| | GNIT_0053 | Glycosyl transferase, family 25. (248 aa) |
| | accB | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (151 aa) |
| | prpD | 2-methylcitrate dehydratase. (495 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (452 aa) |
| | GNIT_3171 | acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | GNIT_3157 | AcnD-accessory protein PrpF. (391 aa) |
| | GNIT_3156 | Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (862 aa) |
| | prpB | 2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (292 aa) |
| | GNIT_3096 | Glycosyl transferase group 1. (403 aa) |
| | rfbD-2 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (302 aa) |
| | GNIT_3011 | Twin-arginine translocation pathway signal. (219 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (272 aa) |
| | fadA-2 | 3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (386 aa) |
| | fadB | Multifunctional fatty acid oxidation complex subunit alpha; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (719 aa) |
| | ispB | Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (323 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (159 aa) |
| | ispD | 4-phosphocytidyl-2C-methyl-D-erythritol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (256 aa) |
| | GNIT_2865 | Phosphopantetheine-binding protein. (81 aa) |
| | plsY | Acyl-phosphate:glycerol-3-phosphate O-acyltransferase PlsY; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (200 aa) |
| | GNIT_2796 | Fused 4-Hydroxybutyrate CoA-transferase/acetyltransferase domain of GNAT. (614 aa) |
| | fabH-2 | 3-oxoacyl-(acyl carrier protein) synthase III. (374 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (391 aa) |
| | lpxC | UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (304 aa) |
| | GNIT_2625 | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (903 aa) |
| | dgkA | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (130 aa) |
| | GNIT_2597 | Glycosyltransferase. (421 aa) |
| | GNIT_2580 | acyl-CoA dehydrogenase. (757 aa) |
| | htrB | Lipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (361 aa) |
| | GNIT_2569 | Lipopolysaccharide biosynthesis. (525 aa) |
| | GNIT_2562 | Glycosyltransferase. (385 aa) |
| | GNIT_2560 | Membrane-anchored group 1 glycosyltransferase. (409 aa) |
| | GNIT_2559 | Glycosyl transferase group 1. (389 aa) |
| | GNIT_2555 | Putative acetyltransferase. (358 aa) |
| | GNIT_2553 | Polysaccharide biosynthesis protein. (493 aa) |
| | GNIT_2551 | Hypothetical protein. (356 aa) |
| | rfbD | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (293 aa) |
| | GNIT_2529 | Protein involved in cellulose biosynthesis (CelD)-like protein. (684 aa) |
| | GNIT_2506 | Glycosyl transferase family protein. (246 aa) |
| | GNIT_2504 | Glycosyl transferase, family 39. (576 aa) |
| | GNIT_2485 | Rhamnosyltransferase. (293 aa) |
| | GNIT_2482 | Polysaccharide biosynthesis protein. (577 aa) |
| | cdsA | Phosphatidate cytidylyltransferase; Belongs to the CDS family. (287 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (403 aa) |
| | fabZ | (3R)-hydroxymyristol acyl carrier protein dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (148 aa) |
| | lpxA | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (256 aa) |
| | lpxB | tetraacyldisaccharide-1-P synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (393 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (318 aa) |
| | GNIT_2394 | Hypothetical protein. (1245 aa) |
| | GNIT_2393 | Polysaccharide biosynthesis protein CapD. (332 aa) |
| | GNIT_2392 | DegT/DnrJ/EryC1/StrS aminotransferase; Belongs to the DegT/DnrJ/EryC1 family. (399 aa) |
| | neuA-2 | Acylneuraminate cytidylyltransferase. (234 aa) |
| | GNIT_2390 | Hypothetical protein. (322 aa) |
| | GNIT_2386 | Putative acyl carrier protein. (81 aa) |
| | neuA | Putative CMP-N-acetlyneuraminic acid synthetase. (383 aa) |
| | GNIT_2305 | Tetratricopeptide TPR_2. (539 aa) |
| | GNIT_2296 | Thioesterase family protein. (142 aa) |
| | fadR | Fatty acid metabolism regulator; Multifunctional regulator of fatty acid metabolism. (236 aa) |
| | fadH-2 | NADH:flavin oxidoreductase/NADH oxidase. (677 aa) |
| | fabB | 3-oxoacyl-(acyl-carrier-protein) synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (404 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (284 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (279 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (320 aa) |
| | lpxK | Tetraacyldisaccharide 4-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (326 aa) |
| | kdsB | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (251 aa) |
| | GNIT_1984 | Putative PRS2 protein. (153 aa) |
| | fabA | 3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (175 aa) |
| | GNIT_1800 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (189 aa) |
| | lapB | Tetratricopeptide repeat protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. (390 aa) |
| | lapA | Hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. (86 aa) |
| | fadE | acyl-CoA dehydrogenase. (826 aa) |
| | fabF | Beta-ketoacyl synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (414 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa) |
| | fabD | Malonyl CoA-acyl carrier protein transacylase. (305 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (320 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (340 aa) |
| | GNIT_1701 | acetyl-CoA acetyltransferase with thiolase domain; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa) |
| | GNIT_1698 | propionyl-CoA carboxylase. (535 aa) |
| | GNIT_1696 | methylcrotonyl-CoA carboxylase, alpha subunit. (668 aa) |
| | GNIT_1687 | Putative acyl-CoA thioesterase, TesB family protein. (267 aa) |
| | GNIT_1565 | Acyl dehydratase. (147 aa) |
| | fadN-2 | 3-hydroxyacyl-CoA dehydrogenase, NAD-binding protein. (704 aa) |
| | GNIT_1544 | AMP-binding protein. (556 aa) |
| | lpxH | UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (241 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (288 aa) |
| | GNIT_1408 | propionyl-CoA carboxylase. (510 aa) |
| | GNIT_1306 | Alcohol dehydrogenase, iron-containing. (366 aa) |
| | GNIT_1293 | AMP-dependent synthetase and ligase. (545 aa) |
| | fadJ | Multifunctional fatty acid oxidation complex subunit alpha; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities. Belongs to the enoyl-CoA hydratase/isomerase family. In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (702 aa) |
| | fadA | 3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (436 aa) |
| | GNIT_1131 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (289 aa) |
| | ispA | Geranyltranstransferase; Belongs to the FPP/GGPP synthase family. (304 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (619 aa) |
| | pgpA | Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (167 aa) |
| | lpxD | Glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (339 aa) |
| | GNIT_1079 | MaoC-like dehydratase. (314 aa) |
| | lytB | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (313 aa) |
| | gcpE | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (373 aa) |
| | GNIT_0996 | Putative secreted hydrolase. (462 aa) |
| | GNIT_0915 | Diacylglycerol kinase (DAGK) (Diglyceride kinase) (DGK); Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (127 aa) |
| | eptA | Putative sulfatase. (575 aa) |
| | kdsC | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (184 aa) |
| | GNIT_0860 | Hypothetical protein. (314 aa) |
| | GNIT_0825 | DNA-binding transcriptional repressor FabR. (199 aa) |
| | fabV | trans-2-enoyl-CoA reductase; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (397 aa) |
| | acpS | 4'-phosphopantetheinyl transferase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (147 aa) |
| | gpsA | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (336 aa) |
| | GNIT_0401 | Polyprenyl synthetase family protein; Belongs to the FPP/GGPP synthase family. (285 aa) |
| | crtI | Phytoene dehydrogenase. (490 aa) |
| | crtB | Phytoene synthase. (313 aa) |
| | GNIT_0397 | Hypothetical protein; Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal. Belongs to the Brp/Blh beta-carotene diooxygenase family. (291 aa) |
| | idi | Putative isopentenyldiphosphate isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (187 aa) |
| | GNIT_0382 | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (435 aa) |
| | GNIT_0326 | Thioesterase superfamily protein. (132 aa) |
| | plsC | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (206 aa) |
| | GNIT_3614 | Hypothetical protein. (202 aa) |
| | GNIT_3612 | Thioesterase superfamily protein. (140 aa) |
| | GNIT_3611 | Putative iron-containing alcohol dehydrogenase. (392 aa) |
| | plsB | Glycerol-3-phosphate acyltransferase; Belongs to the GPAT/DAPAT family. (825 aa) |
| | GNIT_3540 | Hypothetical protein; Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety; Belongs to the PagL family. (193 aa) |
| | GNIT_3499 | Alpha/beta hydrolase fold protein. (351 aa) |
| | GNIT_3490 | Oxidoreductase NAD(P)-binding subunit. (226 aa) |
| | cysQ-2 | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (271 aa) |
| | accC | acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa) |
