STRINGSTRING
AIT78400.1 AIT78400.1 pdhA pdhA AIT78402.1 AIT78402.1 AIT78403.1 AIT78403.1 gabD gabD glsA glsA AIT78530.1 AIT78530.1 AIT78531.1 AIT78531.1 AIT78532.1 AIT78532.1 AIT78540.1 AIT78540.1 AIT78541.1 AIT78541.1 AIT78556.1 AIT78556.1 AIT78560.1 AIT78560.1 AIT78585.1 AIT78585.1 murI murI AIT78689.1 AIT78689.1 AIT78690.1 AIT78690.1 AIT78691.1 AIT78691.1 gcvH gcvH gcvPA gcvPA AIT78780.1 AIT78780.1 gltA gltA pdhA-2 pdhA-2 AIT78937.1 AIT78937.1 AIT78971.1 AIT78971.1 acsA acsA prpE-2 prpE-2 AIT78979.1 AIT78979.1 AIT78981.1 AIT78981.1 AIT79344.1 AIT79344.1 AIT79350.1 AIT79350.1 AIT79402.1 AIT79402.1 putA putA AIT79798.1 AIT79798.1 AIT79843.1 AIT79843.1 AIT79846.1 AIT79846.1 AIT79847.1 AIT79847.1 AIT79848.1 AIT79848.1 AIT79852.1 AIT79852.1 AIT79867.1 AIT79867.1 glnA glnA AIT79919.1 AIT79919.1 fumC fumC AIT80028.1 AIT80028.1 AIT80029.1 AIT80029.1 AIT80093.1 AIT80093.1 AIT80241.1 AIT80241.1 AIT80253.1 AIT80253.1 AIT80273.1 AIT80273.1 AIT80283.1 AIT80283.1 gltD gltD AIT80335.1 AIT80335.1 AIT80336.1 AIT80336.1 sucC sucC proA proA AIT80377.1 AIT80377.1 AIT80401.1 AIT80401.1 gabD-3 gabD-3 purU purU AIT80813.1 AIT80813.1 proB proB AIT81092.1 AIT81092.1 AIT81093.1 AIT81093.1 sucA sucA sucD sucD mdh mdh AIT81175.1 AIT81175.1 AIT81176.1 AIT81176.1 accA accA AIT81383.1 AIT81383.1 AIT81384.1 AIT81384.1 accD accD AIT81443.1 AIT81443.1 AIT81455.1 AIT81455.1 AIT81456.1 AIT81456.1 AIT81457.1 AIT81457.1 glcB glcB AIT81700.1 AIT81700.1 AIT81704.1 AIT81704.1 AIT81705.1 AIT81705.1 AIT81706.1 AIT81706.1 AIT81707.1 AIT81707.1 AIT81735.1 AIT81735.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AIT78400.1acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (582 aa)
pdhAPyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (328 aa)
AIT78402.1Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (323 aa)
AIT78403.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
gabDSuccinate-semialdehyde dehydrogenase; Catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; Derived by automated computational analysis using gene prediction method: Protein Homology. (481 aa)
glsAGlutaminase; Catalyzes the formation of glutamate from glutamine; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutaminase family. (324 aa)
AIT78530.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (131 aa)
AIT78531.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
AIT78532.1Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (602 aa)
AIT78540.12-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (648 aa)
AIT78541.12-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
AIT78556.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (407 aa)
AIT78560.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
AIT78585.1Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (549 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (281 aa)
AIT78689.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (432 aa)
AIT78690.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
AIT78691.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (123 aa)
gcvPAGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (456 aa)
AIT78780.1Glycine dehydrogenase; Acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (534 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (427 aa)
pdhA-2Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (361 aa)
AIT78937.1Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (452 aa)
AIT78971.1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1126 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa)
prpE-2Catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; Derived by automated computational analysis using gene prediction method: Protein Homology. (627 aa)
AIT78979.1E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
AIT78981.1Branched-chain alpha-keto acid dehydrogenase subunit E2; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (436 aa)
AIT79344.1Pyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (574 aa)
AIT79350.1CoA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (697 aa)
AIT79402.1Aconitate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (921 aa)
putATranscriptional regulator; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1203 aa)
AIT79798.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (493 aa)
AIT79843.1Methylmalonate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
AIT79846.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (336 aa)
AIT79847.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
AIT79848.1Dihydrolipoamide acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (76 aa)
AIT79852.1Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
AIT79867.1Converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (451 aa)
glnAForms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
AIT79919.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (298 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
AIT80028.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (488 aa)
AIT80029.1NADH:flavin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (665 aa)
AIT80093.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (890 aa)
AIT80241.1malonyl-CoA decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
AIT80253.15-oxoprolinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1206 aa)
AIT80273.1Malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (753 aa)
AIT80283.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1546 aa)
gltDGlutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
AIT80335.1Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
AIT80336.1Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (399 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (429 aa)
AIT80377.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate synthase family. (528 aa)
AIT80401.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (504 aa)
gabD-3Succinate-semialdehyde dehydrogenase; Catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; Derived by automated computational analysis using gene prediction method: Protein Homology. (484 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa)
AIT80813.1Glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1580 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (376 aa)
AIT81092.1Catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
AIT81093.1Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (409 aa)
sucASucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. (950 aa)
sucDsuccinate--CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
AIT81175.1Isocitrate lyase; Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; Derived by automated computational analysis using gene prediction method: Protein Homology. (530 aa)
AIT81176.1XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
accAacetyl-CoA carboxylase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (315 aa)
AIT81383.1acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (455 aa)
AIT81384.1acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (162 aa)
accDacetyl-CoA carboxyl transferase; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa)
AIT81443.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (718 aa)
AIT81455.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
AIT81456.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
AIT81457.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (704 aa)
AIT81700.1Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
AIT81704.1ATP synthase subunit E; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
AIT81705.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (517 aa)
AIT81706.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (946 aa)
AIT81707.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (73 aa)
AIT81735.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (260 aa)
Your Current Organism:
Novosphingobium pentaromativorans
NCBI taxonomy Id: 1088721
Other names: N. pentaromativorans US6-1, Novosphingobium pentaromativorans US6-1, Novosphingobium pentaromativorans str. US6-1, Novosphingobium pentaromativorans strain US6-1, Novosphingobium sp. US6-1
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