STRINGSTRING
gabD gabD AIT78530.1 AIT78530.1 AIT78531.1 AIT78531.1 AIT78532.1 AIT78532.1 AIT78556.1 AIT78556.1 gltA gltA AIT79402.1 AIT79402.1 fumC fumC AIT80093.1 AIT80093.1 AIT80273.1 AIT80273.1 sucC sucC AIT80401.1 AIT80401.1 gabD-3 gabD-3 purU purU sucD sucD mdh mdh AIT81704.1 AIT81704.1 AIT81705.1 AIT81705.1 AIT81706.1 AIT81706.1 AIT81707.1 AIT81707.1 AIT81735.1 AIT81735.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gabDSuccinate-semialdehyde dehydrogenase; Catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; Derived by automated computational analysis using gene prediction method: Protein Homology. (481 aa)
AIT78530.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (131 aa)
AIT78531.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
AIT78532.1Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (602 aa)
AIT78556.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (407 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (427 aa)
AIT79402.1Aconitate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (921 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
AIT80093.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (890 aa)
AIT80273.1Malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (753 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (399 aa)
AIT80401.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (504 aa)
gabD-3Succinate-semialdehyde dehydrogenase; Catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; Derived by automated computational analysis using gene prediction method: Protein Homology. (484 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa)
sucDsuccinate--CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
AIT81704.1ATP synthase subunit E; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
AIT81705.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (517 aa)
AIT81706.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (946 aa)
AIT81707.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (73 aa)
AIT81735.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (260 aa)
Your Current Organism:
Novosphingobium pentaromativorans
NCBI taxonomy Id: 1088721
Other names: N. pentaromativorans US6-1, Novosphingobium pentaromativorans US6-1, Novosphingobium pentaromativorans str. US6-1, Novosphingobium pentaromativorans strain US6-1, Novosphingobium sp. US6-1
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