(53 nodes) Heterochromatin assembly network (Aspergillus bombycis)

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second shell of interactors

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proteins of unknown 3D structure

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	ABOM_008278	E3 ubiquitin-protein ligase RBX1. (120 aa)
	ABOM_000663	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (587 aa)
	ABOM_000745	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (340 aa)
	ABOM_001570	RNA-dependent RNA polymerase. (772 aa)
	ABOM_001401	WD domain protein. (479 aa)
	ABOM_001009	WD repeat protein. (553 aa)
	ABOM_000920	Heterochromatin protein HP1. (224 aa)
	ABOM_008495	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (324 aa)
	ABOM_011536	CBF/NF-Y family transcription factor. (195 aa)
	ABOM_011020	Histone H2A; Belongs to the histone H2A family. (133 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (810 aa)
	ABOM_011062	Putative ubiquitin ligase subunit CulD; Belongs to the cullin family. (894 aa)
	ABOM_010956	Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex. (251 aa)
	ABOM_011059	GATA transcription factor (Ams2). (1189 aa)
	ABOM_010310	Putative PHD transcription factor. (865 aa)
	ABOM_009770	Histone-lysine N-methyltransferase (Bre2). (605 aa)
	ABOM_010102	DEAD box helicase involved in nonsense mediated decay. (1066 aa)
	ABOM_008894	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones. (502 aa)
	ABOM_008765	tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (477 aa)
	ABOM_009249	Putative negative regulator of DNA transposition. (452 aa)
	ABOM_009325	Uncharacterized protein. (600 aa)
	ABOM_007159	Heat shock protein 90. (699 aa)
	ABOM_006895	RXT2_N domain-containing protein. (532 aa)
	ABOM_007579	NF-X1 finger and helicase domain protein. (532 aa)
	ABOM_008825	Exosome component 3'-5' exonuclease. (766 aa)
	ABOM_005959	SNF2 family helicase/ATPase. (1126 aa)
	ABOM_007580	NF-X1 finger and helicase domain protein. (1307 aa)
	ABOM_006985	DNA helicase ino80. (1692 aa)
	ABOM_007467	Uncharacterized protein. (388 aa)
	ABOM_006085	Uncharacterized protein. (671 aa)
	ABOM_006086	Stc1 domain-containing protein. (290 aa)
	ABOM_006366	Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (490 aa)
	ABOM_005444	Uncharacterized protein. (536 aa)
	ABOM_005522	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (354 aa)
	ABOM_005445	Uncharacterized protein. (1238 aa)
	ABOM_007496	PHD finger domain protein. (596 aa)
	ABOM_009449	Arsenite resistance protein Ars2. (919 aa)
	ABOM_009423	Putative YT521-B-like splicing factor. (622 aa)
	ABOM_008978	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1077 aa)
	ABOM_005340	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (376 aa)
	ABOM_004753	RNA-dependent RNA polymerase. (1404 aa)
	ABOM_004835	zf-C3H1 domain-containing protein. (1240 aa)
	ABOM_004539	Histone H2A; Belongs to the histone H2A family. (138 aa)
	ABOM_004536	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (792 aa)
	ABOM_005025	Uncharacterized protein. (2256 aa)
	ABOM_004403	Chromatin remodeling complex subunit (Chd3). (1453 aa)
	ABOM_004470	Oxidoreductase. (278 aa)
	ABOM_004450	Lysine-specific histone demethylase Aof2. (1139 aa)
	ABOM_004195	Uncharacterized protein. (787 aa)
	ABOM_004216	SIR2 family histone deacetylase (Hst4). (557 aa)
	ABOM_002302	DNA helicase; Belongs to the MCM family. (887 aa)
	ABOM_003556	DNA helicase; Belongs to the MCM family. (719 aa)
	ABOM_001571	RNA-dependent RNA polymerase. (397 aa)

Your Current Organism:

Aspergillus bombycis

NCBI taxonomy Id: 109264
Other names: A. bombycis, Aspergillus bombycis S.W. Peterson, Yoko Ito, B.W. Horn & T. Goto, 2001, CBS 117187, NRRL 26010

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABOM_000663	ABOM_000920	A0A1F8AFT4	A0A1F8AFM6	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Heterochromatin protein HP1.	0.424
ABOM_000663	ABOM_002302	A0A1F8AFT4	A0A1F8ABG4	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	DNA helicase; Belongs to the MCM family.	0.568
ABOM_000663	ABOM_003556	A0A1F8AFT4	A0A1F8ACE8	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	DNA helicase; Belongs to the MCM family.	0.719
ABOM_000663	ABOM_004403	A0A1F8AFT4	A0A1F8A5B4	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Chromatin remodeling complex subunit (Chd3).	0.522
ABOM_000663	ABOM_004539	A0A1F8AFT4	A0A1F8A431	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Histone H2A; Belongs to the histone H2A family.	0.659
ABOM_000663	ABOM_006985	A0A1F8AFT4	A0A1F7ZYB4	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	DNA helicase ino80.	0.467
ABOM_000663	ABOM_009249	A0A1F8AFT4	A0A1F7ZQR2	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Putative negative regulator of DNA transposition.	0.591
ABOM_000663	ABOM_010956	A0A1F8AFT4	A0A1F7ZMP9	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex.	0.431
ABOM_000663	ABOM_011020	A0A1F8AFT4	A0A1F7ZKU9	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	Histone H2A; Belongs to the histone H2A family.	0.932
ABOM_000663	MCM7	A0A1F8AFT4	A0A1F7ZLA7	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.762
ABOM_000745	ABOM_004216	A0A1F8AGA7	A0A1F8A867	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	SIR2 family histone deacetylase (Hst4).	0.854
ABOM_000745	ABOM_004536	A0A1F8AGA7	A0A1F8A445	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.540
ABOM_000745	ABOM_004539	A0A1F8AGA7	A0A1F8A431	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	Histone H2A; Belongs to the histone H2A family.	0.510
ABOM_000745	ABOM_005522	A0A1F8AGA7	A0A1F8A266	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.452
ABOM_000745	ABOM_008894	A0A1F8AGA7	A0A1F7ZPX9	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.	0.485
ABOM_000745	ABOM_008978	A0A1F8AGA7	A0A1F7ZTA9	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.432
ABOM_000920	ABOM_000663	A0A1F8AFM6	A0A1F8AFT4	Heterochromatin protein HP1.	FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]	0.424
ABOM_000920	ABOM_001570	A0A1F8AFM6	A0A1F8ADL4	Heterochromatin protein HP1.	RNA-dependent RNA polymerase.	0.425
ABOM_000920	ABOM_001571	A0A1F8AFM6	A0A1F8ADH3	Heterochromatin protein HP1.	RNA-dependent RNA polymerase.	0.425
ABOM_000920	ABOM_004403	A0A1F8AFM6	A0A1F8A5B4	Heterochromatin protein HP1.	Chromatin remodeling complex subunit (Chd3).	0.906