(50 nodes) TNF signaling, and Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon network (Hippocampus comes)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (771 aa)
	LOC109507455	Uncharacterized protein. (562 aa)
	otulin	Uncharacterized protein. (663 aa)
	ENSHCOP00000000931	Protein kinase domain-containing protein. (480 aa)
	LOC109510598	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	LOC109517693	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	ENSHCOP00000004277	Uncharacterized protein. (121 aa)
	tlr3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (910 aa)
	LOC109525796	Inhibitor of nuclear factor kappa B kinase subunit beta. (674 aa)
	ENSHCOP00000006379	Protein kinase domain-containing protein. (137 aa)
	LOC109522194	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (708 aa)
	tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1. (494 aa)
	LOC109512256	OTU deubiquitinase 7B. (831 aa)
	map3k20	Uncharacterized protein. (788 aa)
	pdzrn3	PDZ domain containing RING finger 3b. (1041 aa)
	ENSHCOP00000008883	Uncharacterized protein. (210 aa)
	optn	Optineurin. (530 aa)
	plekhg7	Pleckstrin homology domain containing, family G (with RhoGef domain) member 7. (413 aa)
	ENSHCOP00000008966	RING-type domain-containing protein. (301 aa)
	LOC109524061	Uncharacterized protein. (935 aa)
	LOC109524107	Nuclear factor of activated T cells 4. (805 aa)
	rbck1	RanBP-type and C3HC4-type zinc finger containing 1. (504 aa)
	ikbkg	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (610 aa)
	ENSHCOP00000011817	Im:7152348. (164 aa)
	zranb1	Zinc finger, RAN-binding domain containing 1a. (714 aa)
	ENSHCOP00000013471	TBD domain-containing protein. (231 aa)
	ENSHCOP00000013487	Uncharacterized protein. (93 aa)
	bag4	BCL2 associated athanogene 4. (358 aa)
	plekhg6	DH domain-containing protein. (361 aa)
	LOC109515323	Tumor necrosis factor receptor superfamily, member 1a. (383 aa)
	map3k9	Mitogen-activated protein kinase kinase kinase 9. (976 aa)
	sharpin	SHANK-associated RH domain interacting protein. (490 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (568 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (562 aa)
	tab3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (610 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (579 aa)
	nod2	Nucleotide-binding oligomerization domain containing 2. (949 aa)
	LOC109520405	TNF receptor-associated factor. (487 aa)
	tradd	Tnfrsf1a-associated via death domain. (288 aa)
	ENSHCOP00000020570	TANK-binding kinase 1. (341 aa)
	tab2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (755 aa)
	FADD	Fas associated via death domain. (188 aa)
	LOC109518471	Uncharacterized protein. (767 aa)
	LOC109511977	Sharpin and rbck1 related. (679 aa)
	LOC109510165	Mitogen-activated protein kinase kinase kinase. (987 aa)
	LOC109523980	Interferon regulatory factor 3. (464 aa)
	LOC109529256	Protein kinase domain-containing protein. (503 aa)
	LOC109509577	Uncharacterized protein. (194 aa)
	ripk1	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like. (677 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (585 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHCOP00000000931	ENSHCOP00000004277	ENSHCOP00000000931	ENSHCOP00000004277	Protein kinase domain-containing protein.	Uncharacterized protein.	0.567
ENSHCOP00000000931	ENSHCOP00000008966	ENSHCOP00000000931	ENSHCOP00000008966	Protein kinase domain-containing protein.	RING-type domain-containing protein.	0.567
ENSHCOP00000000931	ENSHCOP00000011817	ENSHCOP00000000931	ENSHCOP00000011817	Protein kinase domain-containing protein.	Im:7152348.	0.463
ENSHCOP00000000931	FADD	ENSHCOP00000000931	ENSHCOP00000020973	Protein kinase domain-containing protein.	Fas associated via death domain.	0.596
ENSHCOP00000000931	LOC109507455	ENSHCOP00000000931	ENSHCOP00000000220	Protein kinase domain-containing protein.	Uncharacterized protein.	0.547
ENSHCOP00000000931	LOC109510598	ENSHCOP00000000931	ENSHCOP00000001096	Protein kinase domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.484
ENSHCOP00000000931	LOC109515323	ENSHCOP00000000931	ENSHCOP00000014336	Protein kinase domain-containing protein.	Tumor necrosis factor receptor superfamily, member 1a.	0.754
ENSHCOP00000000931	LOC109517693	ENSHCOP00000000931	ENSHCOP00000004161	Protein kinase domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.484
ENSHCOP00000000931	LOC109520405	ENSHCOP00000000931	ENSHCOP00000018839	Protein kinase domain-containing protein.	TNF receptor-associated factor.	0.484
ENSHCOP00000000931	LOC109525796	ENSHCOP00000000931	ENSHCOP00000005828	Protein kinase domain-containing protein.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.666
ENSHCOP00000000931	cyld	ENSHCOP00000000931	ENSHCOP00000000209	Protein kinase domain-containing protein.	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	0.490
ENSHCOP00000000931	ikbkg	ENSHCOP00000000931	ENSHCOP00000011809	Protein kinase domain-containing protein.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.408
ENSHCOP00000000931	nod2	ENSHCOP00000000931	ENSHCOP00000017302	Protein kinase domain-containing protein.	Nucleotide-binding oligomerization domain containing 2.	0.494
ENSHCOP00000000931	plekhg6	ENSHCOP00000000931	ENSHCOP00000014325	Protein kinase domain-containing protein.	DH domain-containing protein.	0.471
ENSHCOP00000000931	ripk1	ENSHCOP00000000931	ENSHCOP00000028031	Protein kinase domain-containing protein.	Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.	0.608
ENSHCOP00000000931	ripk2	ENSHCOP00000000931	ENSHCOP00000028155	Protein kinase domain-containing protein.	Receptor-interacting serine-threonine kinase 2.	0.566
ENSHCOP00000000931	tab1	ENSHCOP00000000931	ENSHCOP00000007866	Protein kinase domain-containing protein.	TGF-beta activated kinase 1/MAP3K7 binding protein 1.	0.922
ENSHCOP00000000931	tab2	ENSHCOP00000000931	ENSHCOP00000020857	Protein kinase domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.821
ENSHCOP00000000931	tab3	ENSHCOP00000000931	ENSHCOP00000015683	Protein kinase domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.824
ENSHCOP00000000931	tlr3	ENSHCOP00000000931	ENSHCOP00000005408	Protein kinase domain-containing protein.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.416