(20 nodes) Mixed, incl. Roundabout binding, and Role of ABL in ROBO-SLIT signaling network (Hippocampus comes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	robo1	Roundabout, axon guidance receptor, homolog 1 (Drosophila). (1585 aa)
	slit2	Slit homolog 2 (Drosophila). (856 aa)
	ENSHCOP00000001285	EGF-like domain-containing protein. (122 aa)
	ENSHCOP00000001289	Uncharacterized protein. (255 aa)
	ENSHCOP00000001355	Uncharacterized protein. (375 aa)
	ENSHCOP00000005899	Uncharacterized protein. (122 aa)
	robo4	Roundabout, axon guidance receptor, homolog 4 (Drosophila). (911 aa)
	robo3	Roundabout, axon guidance receptor, homolog 3 (Drosophila). (1367 aa)
	LOC109511389	Slit homolog 1b (Drosophila). (1430 aa)
	Slitrk5	SLIT and NTRK-like family, member 5a. (883 aa)
	ENSHCOP00000013704	Nyctalopin. (458 aa)
	ENSHCOP00000016048	LRRNT domain-containing protein. (173 aa)
	robo2	Roundabout, axon guidance receptor, homolog 2 (Drosophila). (1202 aa)
	LOC109529083	Slit homolog 3 (Drosophila). (1472 aa)
	ENSHCOP00000021048	Uncharacterized protein. (596 aa)
	ENSHCOP00000021073	Uncharacterized protein. (551 aa)
	epx	Myeloid-specific peroxidase. (781 aa)
	LOC109527560	Leucine rich repeat containing 3Ca. (259 aa)
	slit1	Slit homolog 1a (Drosophila). (1514 aa)
	ENSHCOP00000028390	Uncharacterized protein. (249 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHCOP00000001285	ENSHCOP00000001355	ENSHCOP00000001285	ENSHCOP00000001355	EGF-like domain-containing protein.	Uncharacterized protein.	0.644
ENSHCOP00000001285	ENSHCOP00000005899	ENSHCOP00000001285	ENSHCOP00000005899	EGF-like domain-containing protein.	Uncharacterized protein.	0.677
ENSHCOP00000001285	ENSHCOP00000021048	ENSHCOP00000001285	ENSHCOP00000021048	EGF-like domain-containing protein.	Uncharacterized protein.	0.482
ENSHCOP00000001285	ENSHCOP00000021073	ENSHCOP00000001285	ENSHCOP00000021073	EGF-like domain-containing protein.	Uncharacterized protein.	0.677
ENSHCOP00000001285	robo1	ENSHCOP00000001285	ENSHCOP00000000335	EGF-like domain-containing protein.	Roundabout, axon guidance receptor, homolog 1 (Drosophila).	0.677
ENSHCOP00000001285	robo2	ENSHCOP00000001285	ENSHCOP00000018352	EGF-like domain-containing protein.	Roundabout, axon guidance receptor, homolog 2 (Drosophila).	0.700
ENSHCOP00000001285	robo3	ENSHCOP00000001285	ENSHCOP00000006009	EGF-like domain-containing protein.	Roundabout, axon guidance receptor, homolog 3 (Drosophila).	0.675
ENSHCOP00000001285	robo4	ENSHCOP00000001285	ENSHCOP00000005954	EGF-like domain-containing protein.	Roundabout, axon guidance receptor, homolog 4 (Drosophila).	0.695
ENSHCOP00000001289	ENSHCOP00000001355	ENSHCOP00000001289	ENSHCOP00000001355	Uncharacterized protein.	Uncharacterized protein.	0.482
ENSHCOP00000001289	ENSHCOP00000005899	ENSHCOP00000001289	ENSHCOP00000005899	Uncharacterized protein.	Uncharacterized protein.	0.569
ENSHCOP00000001289	ENSHCOP00000021048	ENSHCOP00000001289	ENSHCOP00000021048	Uncharacterized protein.	Uncharacterized protein.	0.482
ENSHCOP00000001289	ENSHCOP00000021073	ENSHCOP00000001289	ENSHCOP00000021073	Uncharacterized protein.	Uncharacterized protein.	0.482
ENSHCOP00000001289	robo1	ENSHCOP00000001289	ENSHCOP00000000335	Uncharacterized protein.	Roundabout, axon guidance receptor, homolog 1 (Drosophila).	0.482
ENSHCOP00000001289	robo2	ENSHCOP00000001289	ENSHCOP00000018352	Uncharacterized protein.	Roundabout, axon guidance receptor, homolog 2 (Drosophila).	0.482
ENSHCOP00000001289	robo3	ENSHCOP00000001289	ENSHCOP00000006009	Uncharacterized protein.	Roundabout, axon guidance receptor, homolog 3 (Drosophila).	0.482
ENSHCOP00000001289	robo4	ENSHCOP00000001289	ENSHCOP00000005954	Uncharacterized protein.	Roundabout, axon guidance receptor, homolog 4 (Drosophila).	0.482
ENSHCOP00000001289	slit2	ENSHCOP00000001289	ENSHCOP00000001257	Uncharacterized protein.	Slit homolog 2 (Drosophila).	0.900
ENSHCOP00000001355	ENSHCOP00000001285	ENSHCOP00000001355	ENSHCOP00000001285	Uncharacterized protein.	EGF-like domain-containing protein.	0.644
ENSHCOP00000001355	ENSHCOP00000001289	ENSHCOP00000001355	ENSHCOP00000001289	Uncharacterized protein.	Uncharacterized protein.	0.482
ENSHCOP00000001355	ENSHCOP00000013704	ENSHCOP00000001355	ENSHCOP00000013704	Uncharacterized protein.	Nyctalopin.	0.644