(5 nodes) SREBP signaling pathway network (Hippocampus comes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	srebf2	Sterol regulatory element binding transcription factor 2. (1122 aa)
	insig1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (254 aa)
	srebf1	Sterol regulatory element binding transcription factor 1. (1179 aa)
	scap	SREBF chaperone. (1275 aa)
	NPC1L1	NPC1 like intracellular cholesterol transporter 1. (1340 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NPC1L1	insig1	ENSHCOP00000025572	ENSHCOP00000009495	NPC1 like intracellular cholesterol transporter 1.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.	0.799
NPC1L1	srebf1	ENSHCOP00000025572	ENSHCOP00000013700	NPC1 like intracellular cholesterol transporter 1.	Sterol regulatory element binding transcription factor 1.	0.844
NPC1L1	srebf2	ENSHCOP00000025572	ENSHCOP00000004492	NPC1 like intracellular cholesterol transporter 1.	Sterol regulatory element binding transcription factor 2.	0.846
insig1	NPC1L1	ENSHCOP00000009495	ENSHCOP00000025572	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.	NPC1 like intracellular cholesterol transporter 1.	0.799
insig1	scap	ENSHCOP00000009495	ENSHCOP00000023877	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.	SREBF chaperone.	0.961
insig1	srebf1	ENSHCOP00000009495	ENSHCOP00000013700	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.	Sterol regulatory element binding transcription factor 1.	0.594
insig1	srebf2	ENSHCOP00000009495	ENSHCOP00000004492	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.	Sterol regulatory element binding transcription factor 2.	0.594
scap	insig1	ENSHCOP00000023877	ENSHCOP00000009495	SREBF chaperone.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.	0.961
scap	srebf1	ENSHCOP00000023877	ENSHCOP00000013700	SREBF chaperone.	Sterol regulatory element binding transcription factor 1.	0.970
scap	srebf2	ENSHCOP00000023877	ENSHCOP00000004492	SREBF chaperone.	Sterol regulatory element binding transcription factor 2.	0.970
srebf1	NPC1L1	ENSHCOP00000013700	ENSHCOP00000025572	Sterol regulatory element binding transcription factor 1.	NPC1 like intracellular cholesterol transporter 1.	0.844
srebf1	insig1	ENSHCOP00000013700	ENSHCOP00000009495	Sterol regulatory element binding transcription factor 1.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.	0.594
srebf1	scap	ENSHCOP00000013700	ENSHCOP00000023877	Sterol regulatory element binding transcription factor 1.	SREBF chaperone.	0.970
srebf1	srebf2	ENSHCOP00000013700	ENSHCOP00000004492	Sterol regulatory element binding transcription factor 1.	Sterol regulatory element binding transcription factor 2.	0.457
srebf2	NPC1L1	ENSHCOP00000004492	ENSHCOP00000025572	Sterol regulatory element binding transcription factor 2.	NPC1 like intracellular cholesterol transporter 1.	0.846
srebf2	insig1	ENSHCOP00000004492	ENSHCOP00000009495	Sterol regulatory element binding transcription factor 2.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.	0.594
srebf2	scap	ENSHCOP00000004492	ENSHCOP00000023877	Sterol regulatory element binding transcription factor 2.	SREBF chaperone.	0.970
srebf2	srebf1	ENSHCOP00000004492	ENSHCOP00000013700	Sterol regulatory element binding transcription factor 2.	Sterol regulatory element binding transcription factor 1.	0.457