STRINGSTRING
rpa1 rpa1 rad17 rad17 pold4 pold4 LOC109524629 LOC109524629 meiob meiob topbp1 topbp1 rfc1 rfc1 mad2l2 mad2l2 Ercc5 Ercc5 ENSHCOP00000002291 ENSHCOP00000002291 rev1 rev1 msh4 msh4 mlh1 mlh1 pcna pcna FEN1 FEN1 msh5 msh5 Rad9b Rad9b LOC109527038 LOC109527038 mre11 mre11 rmi2 rmi2 rpa2 rpa2 rev3l rev3l nbn nbn rad51ap1 rad51ap1 exo1 exo1 xrcc3 xrcc3 pwwp2a pwwp2a LOC109531265 LOC109531265 ENSHCOP00000007050 ENSHCOP00000007050 ENSHCOP00000007515 ENSHCOP00000007515 rad9a rad9a rad51d rad51d rmi1 rmi1 palb2 palb2 ENSHCOP00000009180 ENSHCOP00000009180 Atm Atm paxip1 paxip1 pold3 pold3 LOC109517068 LOC109517068 msh6 msh6 rad51b rad51b hus1 hus1 ENSHCOP00000011006 ENSHCOP00000011006 rfc4 rfc4 bivm bivm ENSHCOP00000011034 ENSHCOP00000011034 ENSHCOP00000011108 ENSHCOP00000011108 mlh3 mlh3 pms2 pms2 atrip atrip chtf8 chtf8 top3b top3b Polk Polk mcph1 mcph1 recql4 recql4 msh2 msh2 ercc1 ercc1 LOC109520519 LOC109520519 poli poli brca1 brca1 chtf18 chtf18 xpa xpa rfc5 rfc5 LOC109532275 LOC109532275 LOC109512331 LOC109512331 rad51c rad51c rad50 rad50 msh3 msh3 top3a top3a tp53bp1 tp53bp1 xrcc2 xrcc2 rfc3 rfc3 pms1 pms1 ENSHCOP00000023012 ENSHCOP00000023012 blm blm rad52 rad52 rfc2 rfc2 rad1 rad1 dscc1 dscc1 mdc1 mdc1 lig1 lig1 ENSHCOP00000023908 ENSHCOP00000023908 rad51 rad51 pold1 pold1 dna2 dna2 rpa3 rpa3 Atr Atr ercc4 ercc4 pold2 pold2 rbbp8 rbbp8 LOC109509834 LOC109509834 ENSHCOP00000026411 ENSHCOP00000026411 polh polh exd2 exd2 Slf1 Slf1 ENSHCOP00000028059 ENSHCOP00000028059
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (611 aa)
rad17RAD17 checkpoint clamp loader component. (570 aa)
pold4Si:dkey-28b4.7. (106 aa)
LOC109524629Tudor domain containing 3. (756 aa)
meiobMethionine sulfoxide reductase B1b. (439 aa)
topbp1DNA topoisomerase II binding protein 1. (1350 aa)
rfc1Replication factor C subunit 1. (1130 aa)
mad2l2Mitotic arrest deficient 2 like 2. (210 aa)
Ercc5XPGI domain-containing protein. (373 aa)
ENSHCOP00000002291XPGN domain-containing protein. (242 aa)
rev1REV1 DNA directed polymerase. (809 aa)
msh4DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (894 aa)
mlh1MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (731 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (371 aa)
msh5MutS homolog 5. (819 aa)
Rad9bUncharacterized protein. (173 aa)
LOC109527038ATPase family AAA domain containing 5a. (1619 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (738 aa)
rmi2RecQ mediated genome instability 2. (158 aa)
rpa2Replication protein A2. (314 aa)
rev3lREV3 like, DNA directed polymerase zeta catalytic subunit. (2836 aa)
nbnNibrin. (832 aa)
rad51ap1RAD51_interact domain-containing protein. (275 aa)
exo1Exonuclease 1. (763 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (341 aa)
pwwp2aPWWP domain containing 2A. (705 aa)
LOC109531265BRCA1 associated RING domain 1. (783 aa)
ENSHCOP00000007050Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
ENSHCOP00000007515Uncharacterized protein. (89 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (382 aa)
rad51dRAD51 paralog D. (337 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (494 aa)
palb2PALB2_WD40 domain-containing protein. (1012 aa)
ENSHCOP00000009180Uncharacterized protein. (169 aa)
AtmTAN domain-containing protein. (311 aa)
paxip1PAX interacting (with transcription-activation domain) protein 1. (1143 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (437 aa)
LOC109517068Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (572 aa)
msh6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1375 aa)
rad51bRAD51 paralog B. (330 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (285 aa)
ENSHCOP00000011006Uncharacterized protein. (639 aa)
rfc4Replication factor C (activator 1) 4. (331 aa)
bivmBasic, immunoglobulin-like variable motif containing. (472 aa)
ENSHCOP00000011034FA complementation group M. (394 aa)
ENSHCOP00000011108HATPase_c domain-containing protein. (126 aa)
mlh3MutL homolog 3 (E. coli). (924 aa)
pms2PMS1 homolog 2, mismatch repair system component. (875 aa)
atripUncharacterized protein. (764 aa)
chtf8CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (135 aa)
top3bDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (856 aa)
PolkPolymerase (DNA directed) kappa. (396 aa)
mcph1Microcephalin 1. (699 aa)
recql4RecQ helicase-like 4. (947 aa)
msh2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa)
ercc1Excision repair cross-complementation group 1. (338 aa)
LOC109520519Zgc:110269. (317 aa)
poliPolymerase (DNA directed) iota. (621 aa)
brca1Uncharacterized protein. (1141 aa)
chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae). (922 aa)
xpaXeroderma pigmentosum, complementation group A. (279 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
LOC109532275SCY domain-containing protein. (126 aa)
LOC109512331UmuC domain-containing protein. (184 aa)
rad51cRAD51 paralog C. (355 aa)
rad50RAD50 homolog, double strand break repair protein. (1285 aa)
msh3MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). (1057 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (726 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1495 aa)
xrcc2Rad51 domain-containing protein. (353 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
pms1PMS1 homolog 1, mismatch repair system component. (904 aa)
ENSHCOP00000023012Uncharacterized protein. (1155 aa)
blmATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (966 aa)
rad52RAD52 homolog, DNA repair protein. (392 aa)
rfc2Replication factor C (activator 1) 2. (244 aa)
rad1RAD1 homolog (S. pombe). (279 aa)
dscc1DNA replication and sister chromatid cohesion 1. (390 aa)
mdc1BRCT domain-containing protein. (1811 aa)
lig1DNA ligase. (902 aa)
ENSHCOP00000023908Uncharacterized protein. (105 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
pold1DNA polymerase. (1105 aa)
dna2DNA replication helicase/nuclease 2. (1305 aa)
rpa3Replication protein A3. (127 aa)
AtrUncharacterized protein. (106 aa)
ercc4Excision repair cross-complementation group 4. (900 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (470 aa)
rbbp8Uncharacterized protein. (638 aa)
LOC109509834XPGI domain-containing protein. (306 aa)
ENSHCOP00000026411Uncharacterized protein. (408 aa)
polhPolymerase (DNA directed), eta. (483 aa)
exd2Exonuclease 3'-5' domain containing 2. (633 aa)
Slf1Uncharacterized protein. (142 aa)
ENSHCOP00000028059Uncharacterized protein. (127 aa)
Your Current Organism:
Hippocampus comes
NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.