(15 nodes) Mixed, incl. RecQ family helicase-topoisomerase III complex, and DNA replication factor A complex network (Hippocampus comes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (611 aa)
	LOC109524629	Tudor domain containing 3. (756 aa)
	rmi2	RecQ mediated genome instability 2. (158 aa)
	rpa2	Replication protein A2. (314 aa)
	ENSHCOP00000007050	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
	rmi1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (494 aa)
	LOC109517068	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (572 aa)
	ENSHCOP00000011006	Uncharacterized protein. (639 aa)
	ENSHCOP00000011034	FA complementation group M. (394 aa)
	top3b	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (856 aa)
	top3a	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (726 aa)
	blm	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (966 aa)
	rad52	RAD52 homolog, DNA repair protein. (392 aa)
	rpa3	Replication protein A3. (127 aa)
	ENSHCOP00000028059	Uncharacterized protein. (127 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHCOP00000007050	ENSHCOP00000011006	ENSHCOP00000007050	ENSHCOP00000011006	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Uncharacterized protein.	0.964
ENSHCOP00000007050	ENSHCOP00000011034	ENSHCOP00000007050	ENSHCOP00000011034	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	FA complementation group M.	0.964
ENSHCOP00000007050	ENSHCOP00000028059	ENSHCOP00000007050	ENSHCOP00000028059	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Uncharacterized protein.	0.884
ENSHCOP00000007050	LOC109517068	ENSHCOP00000007050	ENSHCOP00000009787	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.916
ENSHCOP00000007050	LOC109524629	ENSHCOP00000007050	ENSHCOP00000001215	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Tudor domain containing 3.	0.602
ENSHCOP00000007050	blm	ENSHCOP00000007050	ENSHCOP00000023146	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.820
ENSHCOP00000007050	rad52	ENSHCOP00000007050	ENSHCOP00000023241	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	RAD52 homolog, DNA repair protein.	0.840
ENSHCOP00000007050	rmi1	ENSHCOP00000007050	ENSHCOP00000008786	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae).	0.792
ENSHCOP00000007050	rmi2	ENSHCOP00000007050	ENSHCOP00000004996	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	RecQ mediated genome instability 2.	0.467
ENSHCOP00000007050	rpa1	ENSHCOP00000007050	ENSHCOP00000000570	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.916
ENSHCOP00000007050	rpa3	ENSHCOP00000007050	ENSHCOP00000025134	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Replication protein A3.	0.884
ENSHCOP00000007050	top3a	ENSHCOP00000007050	ENSHCOP00000019422	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.798
ENSHCOP00000007050	top3b	ENSHCOP00000007050	ENSHCOP00000011959	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.586
ENSHCOP00000011006	ENSHCOP00000007050	ENSHCOP00000011006	ENSHCOP00000007050	Uncharacterized protein.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.964
ENSHCOP00000011006	ENSHCOP00000011034	ENSHCOP00000011006	ENSHCOP00000011034	Uncharacterized protein.	FA complementation group M.	0.997
ENSHCOP00000011006	ENSHCOP00000028059	ENSHCOP00000011006	ENSHCOP00000028059	Uncharacterized protein.	Uncharacterized protein.	0.941
ENSHCOP00000011006	LOC109517068	ENSHCOP00000011006	ENSHCOP00000009787	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.999
ENSHCOP00000011006	LOC109524629	ENSHCOP00000011006	ENSHCOP00000001215	Uncharacterized protein.	Tudor domain containing 3.	0.998
ENSHCOP00000011006	blm	ENSHCOP00000011006	ENSHCOP00000023146	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.998
ENSHCOP00000011006	rad52	ENSHCOP00000011006	ENSHCOP00000023241	Uncharacterized protein.	RAD52 homolog, DNA repair protein.	0.970