(62 nodes) Protease binding network (Hippocampus comes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109510471	Surfactant protein Bb. (349 aa)
	twnk	Twinkle mtDNA helicase. (703 aa)
	LOC109531076	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1678 aa)
	LOC109510825	Uncharacterized protein. (393 aa)
	LOC109516609	Integrin, alpha 3b; Belongs to the integrin alpha chain family. (1011 aa)
	LOC109521513	BHLH domain-containing protein. (327 aa)
	serpinf2	SERPIN domain-containing protein; Belongs to the serpin family. (471 aa)
	ENSHCOP00000000810	MALT paracaspase 2. (513 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (753 aa)
	LOC109514626	Extracellular matrix protein 1a. (139 aa)
	ENSHCOP00000001552	Uncharacterized protein. (133 aa)
	ENSHCOP00000002481	BCL2 apoptosis regulator b. (221 aa)
	ENSHCOP00000002506	BCL2 apoptosis regulator b. (225 aa)
	LOC109512850	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1677 aa)
	Polg	Polymerase (DNA directed), gamma. (449 aa)
	derl1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (257 aa)
	LOC109516310	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (448 aa)
	riok3	Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (517 aa)
	LOC109525037	Uncharacterized protein. (394 aa)
	selenos	Uncharacterized protein. (193 aa)
	LOC109519380	TIMP metallopeptidase inhibitor 2b. (211 aa)
	LOC109519376	NTR domain-containing protein. (203 aa)
	LOC109519374	TIMP metallopeptidase inhibitor 2b. (212 aa)
	LOC109519375	TIMP metallopeptidase inhibitor 2b. (207 aa)
	LOC109519377	TIMP metallopeptidase inhibitor 2b. (199 aa)
	yipf5	Protein YIPF. (256 aa)
	fbxo45	F-box protein 45. (287 aa)
	cflar	Uncharacterized protein; Belongs to the peptidase C14A family. (480 aa)
	trip4	Thyroid hormone receptor interactor 4. (572 aa)
	rnf139	Ring finger protein 139. (698 aa)
	TIMP4	TIMP metallopeptidase inhibitor 4, tandem duplicate 1. (221 aa)
	ENSHCOP00000016231	Si:dkey-63b1.1; Belongs to the G-protein coupled receptor 1 family. (345 aa)
	ENSHCOP00000016272	Uncharacterized protein. (1636 aa)
	LOC109521563	NTR domain-containing protein. (201 aa)
	LOC109514032	BCL2 like 10. (200 aa)
	LOC109506810	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family. (409 aa)
	BDKRB2	Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (384 aa)
	tysnd1	Trypsin domain containing 1. (520 aa)
	BFAR	Bifunctional apoptosis regulator. (480 aa)
	serpine1	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (392 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (213 aa)
	LOC109526505	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
	LOC109529028	Uncharacterized protein. (499 aa)
	FADD	Fas associated via death domain. (188 aa)
	flot2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (429 aa)
	ADRM1	Adhesion regulating molecule 1. (417 aa)
	ENSHCOP00000023012	Uncharacterized protein. (1155 aa)
	LOC109531236	MALT paracaspase 3. (638 aa)
	LOC109524148	Uncharacterized protein. (284 aa)
	LOC109531179	PDZ domain containing 3b. (474 aa)
	psap	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (534 aa)
	LOC109531636	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (388 aa)
	marchf6	Membrane-associated ring finger (C3HC4) 6. (912 aa)
	ENSHCOP00000025423	Uncharacterized protein. (185 aa)
	LOC109516494	TIMP metallopeptidase inhibitor 2a. (220 aa)
	amfr	Autocrine motility factor receptor b. (623 aa)
	LOC109522067	Fibronectin 1a. (2484 aa)
	nfrkb	Nuclear factor related to kappaB binding protein. (1123 aa)
	chmp3	Charged multivesicular body protein 3. (219 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (585 aa)
	f3	Coagulation factor IIIa. (281 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (433 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRM1	tysnd1	ENSHCOP00000022726	ENSHCOP00000018360	Adhesion regulating molecule 1.	Trypsin domain containing 1.	0.590
BDKRB2	ENSHCOP00000016231	ENSHCOP00000017538	ENSHCOP00000016231	Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family.	Si:dkey-63b1.1; Belongs to the G-protein coupled receptor 1 family.	0.901
ENSHCOP00000002481	LOC109514032	ENSHCOP00000002481	ENSHCOP00000016524	BCL2 apoptosis regulator b.	BCL2 like 10.	0.469
ENSHCOP00000002481	cflar	ENSHCOP00000002481	ENSHCOP00000014172	BCL2 apoptosis regulator b.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.460
ENSHCOP00000002506	LOC109514032	ENSHCOP00000002506	ENSHCOP00000016524	BCL2 apoptosis regulator b.	BCL2 like 10.	0.469
ENSHCOP00000002506	cflar	ENSHCOP00000002506	ENSHCOP00000014172	BCL2 apoptosis regulator b.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.460
ENSHCOP00000016231	BDKRB2	ENSHCOP00000016231	ENSHCOP00000017538	Si:dkey-63b1.1; Belongs to the G-protein coupled receptor 1 family.	Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family.	0.901
ENSHCOP00000023012	Polg	ENSHCOP00000023012	ENSHCOP00000008193	Uncharacterized protein.	Polymerase (DNA directed), gamma.	0.491
ENSHCOP00000025423	TIMP3	ENSHCOP00000025423	ENSHCOP00000019995	Uncharacterized protein.	TIMP metallopeptidase inhibitor 3.	0.447
FADD	LOC109525037	ENSHCOP00000020973	ENSHCOP00000005056	Fas associated via death domain.	Uncharacterized protein.	0.707
FADD	cflar	ENSHCOP00000020973	ENSHCOP00000014172	Fas associated via death domain.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.962
FADD	ripk2	ENSHCOP00000020973	ENSHCOP00000028155	Fas associated via death domain.	Receptor-interacting serine-threonine kinase 2.	0.710
FADD	tnfaip3	ENSHCOP00000020973	ENSHCOP00000001357	Fas associated via death domain.	Tumor necrosis factor, alpha-induced protein 3.	0.667
LOC109506810	LOC109524148	ENSHCOP00000016960	ENSHCOP00000023351	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.	Uncharacterized protein.	0.623
LOC109506810	serpinf2	ENSHCOP00000016960	ENSHCOP00000000560	Serpin peptidase inhibitor, clade C (antithrombin), member 1; Belongs to the serpin family.	SERPIN domain-containing protein; Belongs to the serpin family.	0.738
LOC109510471	LOC109512850	ENSHCOP00000008717	ENSHCOP00000008703	Surfactant protein Bb.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.465
LOC109510471	LOC109526505	ENSHCOP00000008717	ENSHCOP00000020868	Surfactant protein Bb.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.465
LOC109510471	LOC109531076	ENSHCOP00000008717	ENSHCOP00000009726	Surfactant protein Bb.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.465
LOC109510471	psap	ENSHCOP00000008717	ENSHCOP00000023558	Surfactant protein Bb.	Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.	0.900
LOC109512850	LOC109510471	ENSHCOP00000008703	ENSHCOP00000008717	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Surfactant protein Bb.	0.465