51 items (Hippocampus comes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	blm	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (966 aa)
	LOC109519212	Uncharacterized protein. (175 aa)
	ENSHCOP00000002109	Uncharacterized protein. (765 aa)
	usp10	Ubiquitin carboxyl-terminal hydrolase. (871 aa)
	LOC109521629	GATA binding protein 1a. (416 aa)
	LOC109523155	Sirtuin 1. (657 aa)
	Triap1	TP53 regulated inhibitor of apoptosis 1. (83 aa)
	cdk5	Cyclin-dependent kinase 5. (258 aa)
	LOC109514441	Ring finger and FYVE-like domain containing E3 ubiquitin protein ligase. (328 aa)
	LOC109514325	CDKN2A interacting protein. (315 aa)
	Ehmt2	Uncharacterized protein. (292 aa)
	ENSHCOP00000005428	ANK_REP_REGION domain-containing protein. (156 aa)
	mul1	Mitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
	LOC109532526	Uncharacterized protein. (1579 aa)
	ENSHCOP00000006772	Uncharacterized protein. (615 aa)
	mdm4	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (456 aa)
	rfwd3	Ring finger and WD repeat domain 3. (697 aa)
	LOC109512841	E1A binding protein p300 a. (2561 aa)
	msx1	Muscle segment homeobox 1a. (286 aa)
	psme3	Proteasome activator subunit 3. (263 aa)
	ENSHCOP00000009657	ANK_REP_REGION domain-containing protein. (137 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (839 aa)
	tp63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (544 aa)
	ENSHCOP00000012506	Ring finger protein 34a. (338 aa)
	LOC109516237	Muscle segment homeobox 3. (253 aa)
	chd8	Chromodomain helicase DNA binding protein 8. (2051 aa)
	prmt5	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (631 aa)
	htt	Huntingtin. (2861 aa)
	brd7	Bromodomain containing 7. (602 aa)
	LOC109527342	CREB binding protein a. (2447 aa)
	daxx	Daxx domain-containing protein. (492 aa)
	LOC109510555	Euchromatic histone-lysine N-methyltransferase 1a. (842 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1111 aa)
	LOC109527076	Euchromatic histone-lysine N-methyltransferase 1b. (1186 aa)
	ENSHCOP00000018882	annotation not available (86 aa)
	mdm2	MDM2 proto-oncogene. (515 aa)
	ENSHCOP00000019285	Deacetylase sirtuin-type domain-containing protein. (166 aa)
	ENSHCOP00000019306	Sirtuin 1. (369 aa)
	mapkapk5	MAPK activated protein kinase 5. (471 aa)
	rchy1	Ring finger and CHY zinc finger domain containing 1. (269 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1495 aa)
	LOC109532549	CREB binding protein b. (1735 aa)
	TAF3	TATA-box binding protein associated factor 3. (654 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (430 aa)
	tp73	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (571 aa)
	LOC109511947	Ring finger protein 34b. (365 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (478 aa)
	tp53rk	TP53 regulating kinase. (237 aa)
	LOC109507480	Bromodomain containing 4. (1553 aa)
	LOC109514850	E1A binding protein p300 b. (2669 aa)
	ENSHCOP00000023803	Uncharacterized protein. (1781 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHCOP00000005428	Ehmt2	ENSHCOP00000005428	ENSHCOP00000005412	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.899
ENSHCOP00000005428	kdm1a	ENSHCOP00000005428	ENSHCOP00000010393	ANK_REP_REGION domain-containing protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.486
ENSHCOP00000006772	ENSHCOP00000018882	ENSHCOP00000006772	ENSHCOP00000018882	Uncharacterized protein.	annotation not available	0.480
ENSHCOP00000006772	ENSHCOP00000019285	ENSHCOP00000006772	ENSHCOP00000019285	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.400
ENSHCOP00000006772	ENSHCOP00000019306	ENSHCOP00000006772	ENSHCOP00000019306	Uncharacterized protein.	Sirtuin 1.	0.400
ENSHCOP00000006772	LOC109512841	ENSHCOP00000006772	ENSHCOP00000007909	Uncharacterized protein.	E1A binding protein p300 a.	0.854
ENSHCOP00000006772	LOC109514850	ENSHCOP00000006772	ENSHCOP00000024673	Uncharacterized protein.	E1A binding protein p300 b.	0.854
ENSHCOP00000006772	LOC109521629	ENSHCOP00000006772	ENSHCOP00000002614	Uncharacterized protein.	GATA binding protein 1a.	0.480
ENSHCOP00000006772	LOC109523155	ENSHCOP00000006772	ENSHCOP00000003219	Uncharacterized protein.	Sirtuin 1.	0.400
ENSHCOP00000006772	LOC109532549	ENSHCOP00000006772	ENSHCOP00000021630	Uncharacterized protein.	CREB binding protein b.	0.925
ENSHCOP00000006772	brd7	ENSHCOP00000006772	ENSHCOP00000017306	Uncharacterized protein.	Bromodomain containing 7.	0.496
ENSHCOP00000006772	htt	ENSHCOP00000006772	ENSHCOP00000015436	Uncharacterized protein.	Huntingtin.	0.665
ENSHCOP00000006772	kdm1a	ENSHCOP00000006772	ENSHCOP00000010393	Uncharacterized protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.477
ENSHCOP00000006772	mdm2	ENSHCOP00000006772	ENSHCOP00000019043	Uncharacterized protein.	MDM2 proto-oncogene.	0.507
ENSHCOP00000006772	prmt5	ENSHCOP00000006772	ENSHCOP00000013646	Uncharacterized protein.	Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily.	0.426
ENSHCOP00000006772	tp63	ENSHCOP00000006772	ENSHCOP00000011142	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.462
ENSHCOP00000006772	tp73	ENSHCOP00000006772	ENSHCOP00000028288	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.462
ENSHCOP00000009657	Ehmt2	ENSHCOP00000009657	ENSHCOP00000005412	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.899
ENSHCOP00000009657	kdm1a	ENSHCOP00000009657	ENSHCOP00000010393	ANK_REP_REGION domain-containing protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.486
ENSHCOP00000018882	ENSHCOP00000006772	ENSHCOP00000018882	ENSHCOP00000006772	annotation not available	Uncharacterized protein.	0.480