55 items (Hippocampus comes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	recql4	RecQ helicase-like 4. (947 aa)
	ercc2	Excision repair cross-complementation group 2. (591 aa)
	ddb2	Damage-specific DNA binding protein 2. (489 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa)
	ercc1	Excision repair cross-complementation group 1. (338 aa)
	ddb1	Damage-specific DNA binding protein 1. (1093 aa)
	LOC109528114	RAD23 homolog B, nucleotide excision repair protein. (380 aa)
	rad23a	RAD23 homolog A, nucleotide excision repair protein a. (367 aa)
	Polk	Polymerase (DNA directed) kappa. (396 aa)
	nbn	Nibrin. (832 aa)
	ung	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (296 aa)
	xrcc6	X-ray repair complementing defective repair in Chinese hamster cells 6. (609 aa)
	MUTYH	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (526 aa)
	blm	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (966 aa)
	pold1	DNA polymerase. (1105 aa)
	LOC109514850	E1A binding protein p300 b. (2669 aa)
	rpa3	Replication protein A3. (127 aa)
	ercc4	Excision repair cross-complementation group 4. (900 aa)
	rbbp8	Uncharacterized protein. (638 aa)
	polh	Polymerase (DNA directed), eta. (483 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (729 aa)
	LOC109530089	Cryptochrome circadian regulator 1a. (627 aa)
	pot1	Protection of telomeres 1 homolog. (842 aa)
	LOC109512841	E1A binding protein p300 a. (2561 aa)
	xpc	Xeroderma pigmentosum, complementation group C. (859 aa)
	LOC109532589	DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (606 aa)
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (612 aa)
	ENSHCOP00000002904	DNA cross-link repair 1B. (472 aa)
	cry1	Cryptochrome circadian regulator 1b. (559 aa)
	ogg1	8-oxoguanine DNA glycosylase. (413 aa)
	LOC109532526	Uncharacterized protein. (1579 aa)
	ENSHCOP00000006772	Uncharacterized protein. (615 aa)
	neil3	Nei-like DNA glycosylase 3. (522 aa)
	LOC109525230	RAD23 homolog A, nucleotide excision repair protein b. (443 aa)
	ENSHCOP00000008016	Uncharacterized protein. (88 aa)
	msh6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1375 aa)
	rev1	REV1 DNA directed polymerase. (809 aa)
	LOC109517068	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (572 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (611 aa)
	sirt6	Sirtuin 6. (347 aa)
	LOC109514060	Cryptochrome DASH. (521 aa)
	aunip	Uncharacterized protein. (264 aa)
	nthl1	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (405 aa)
	neil1	Nei-like DNA glycosylase 1. (362 aa)
	apex1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (311 aa)
	LOC109532549	CREB binding protein b. (1735 aa)
	ENSHCOP00000028059	Uncharacterized protein. (127 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1495 aa)
	LOC109512331	UmuC domain-containing protein. (184 aa)
	LOC109527342	CREB binding protein a. (2447 aa)
	xpa	Xeroderma pigmentosum, complementation group A. (279 aa)
	brca1	Uncharacterized protein. (1141 aa)
	dclre1a	DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae). (587 aa)
	poli	Polymerase (DNA directed) iota. (621 aa)
	fancg	FA complementation group G. (584 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHCOP00000002904	brca1	ENSHCOP00000002904	ENSHCOP00000016663	DNA cross-link repair 1B.	Uncharacterized protein.	0.473
ENSHCOP00000002904	dclre1a	ENSHCOP00000002904	ENSHCOP00000017094	DNA cross-link repair 1B.	DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae).	0.518
ENSHCOP00000002904	ercc1	ENSHCOP00000002904	ENSHCOP00000014052	DNA cross-link repair 1B.	Excision repair cross-complementation group 1.	0.718
ENSHCOP00000002904	ercc4	ENSHCOP00000002904	ENSHCOP00000025158	DNA cross-link repair 1B.	Excision repair cross-complementation group 4.	0.669
ENSHCOP00000002904	fancg	ENSHCOP00000002904	ENSHCOP00000012620	DNA cross-link repair 1B.	FA complementation group G.	0.475
ENSHCOP00000002904	msh2	ENSHCOP00000002904	ENSHCOP00000013100	DNA cross-link repair 1B.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.492
ENSHCOP00000002904	nbn	ENSHCOP00000002904	ENSHCOP00000005524	DNA cross-link repair 1B.	Nibrin.	0.666
ENSHCOP00000002904	pot1	ENSHCOP00000002904	ENSHCOP00000007887	DNA cross-link repair 1B.	Protection of telomeres 1 homolog.	0.543
ENSHCOP00000002904	tp53bp1	ENSHCOP00000002904	ENSHCOP00000020451	DNA cross-link repair 1B.	Tumor protein p53 binding protein, 1.	0.568
ENSHCOP00000002904	xpa	ENSHCOP00000002904	ENSHCOP00000016946	DNA cross-link repair 1B.	Xeroderma pigmentosum, complementation group A.	0.518
ENSHCOP00000002904	xrcc1	ENSHCOP00000002904	ENSHCOP00000004092	DNA cross-link repair 1B.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.407
ENSHCOP00000002904	xrcc5	ENSHCOP00000002904	ENSHCOP00000026645	DNA cross-link repair 1B.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.848
ENSHCOP00000002904	xrcc6	ENSHCOP00000002904	ENSHCOP00000007729	DNA cross-link repair 1B.	X-ray repair complementing defective repair in Chinese hamster cells 6.	0.851
ENSHCOP00000006772	LOC109512841	ENSHCOP00000006772	ENSHCOP00000007909	Uncharacterized protein.	E1A binding protein p300 a.	0.854
ENSHCOP00000006772	LOC109514850	ENSHCOP00000006772	ENSHCOP00000024673	Uncharacterized protein.	E1A binding protein p300 b.	0.854
ENSHCOP00000006772	LOC109532549	ENSHCOP00000006772	ENSHCOP00000021630	Uncharacterized protein.	CREB binding protein b.	0.925
ENSHCOP00000006772	brca1	ENSHCOP00000006772	ENSHCOP00000016663	Uncharacterized protein.	Uncharacterized protein.	0.623
ENSHCOP00000006772	xpa	ENSHCOP00000006772	ENSHCOP00000016946	Uncharacterized protein.	Xeroderma pigmentosum, complementation group A.	0.537
ENSHCOP00000008016	MUTYH	ENSHCOP00000008016	ENSHCOP00000022619	Uncharacterized protein.	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	0.614
ENSHCOP00000008016	apex1	ENSHCOP00000008016	ENSHCOP00000022342	Uncharacterized protein.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.771