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| | ENSHCOP00000008991 | GIY-YIG domain-containing protein. (84 aa) |
| | LOC109508453 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (241 aa) |
| | ap5s1 | Adaptor related protein complex 5 subunit sigma 1. (200 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (494 aa) |
| | ENSHCOP00000008605 | F-box domain-containing protein. (729 aa) |
| | ENSHCOP00000008383 | Uncharacterized protein. (57 aa) |
| | LOC109512952 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (525 aa) |
| | ENSHCOP00000008016 | Uncharacterized protein. (88 aa) |
| | lig3 | DNA ligase. (993 aa) |
| | mus81 | MUS81 structure-specific endonuclease subunit. (381 aa) |
| | rbbp8 | Uncharacterized protein. (638 aa) |
| | ENSHCOP00000026411 | Uncharacterized protein. (408 aa) |
| | pagr1 | PAXIP1 associated glutamate-rich protein 1. (252 aa) |
| | xrcc5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (729 aa) |
| | pgbd5 | PiggyBac transposable element derived 5. (548 aa) |
| | fan1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (498 aa) |
| | aicda | Activation-induced cytidine deaminase. (189 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (633 aa) |
| | LOC109514688 | nipped-B-like protein B. (104 aa) |
| | ENSHCOP00000027456 | DNA helicase; Belongs to the MCM family. (702 aa) |
| | aunip | Uncharacterized protein. (264 aa) |
| | rnf168 | RING-type domain-containing protein. (444 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (939 aa) |
| | cdc7 | Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily. (486 aa) |
| | Hfm1 | Helicase for meiosis 1. (797 aa) |
| | hdgfl2 | HDGF like 2. (621 aa) |
| | psmd14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | ENSHCOP00000028059 | Uncharacterized protein. (127 aa) |
| | mcm8 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (828 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (738 aa) |
| | rad51d | RAD51 paralog D. (337 aa) |
| | xrcc6 | X-ray repair complementing defective repair in Chinese hamster cells 6. (609 aa) |
| | ung | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (296 aa) |
| | smc6 | Si:dkey-119f1.1. (1086 aa) |
| | ENSHCOP00000007138 | Uncharacterized protein. (299 aa) |
| | rfwd3 | Ring finger and WD repeat domain 3. (697 aa) |
| | ENSHCOP00000007080 | Rad21_Rec8_N domain-containing protein. (143 aa) |
| | C1orf146 | Chromosome 1 open reading frame 146. (161 aa) |
| | poll | Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (560 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (643 aa) |
| | ENSHCOP00000012322 | HATPase_c domain-containing protein. (202 aa) |
| | supv3l1 | SUV3-like helicase. (781 aa) |
| | ENSHCOP00000011006 | Uncharacterized protein. (639 aa) |
| | rpa3 | Replication protein A3. (127 aa) |
| | recql5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (931 aa) |
| | mms22l | MMS22-like, DNA repair protein. (1222 aa) |
| | tonsl | Tonsoku-like, DNA repair protein. (1268 aa) |
| | ENSHCOP00000024667 | Uncharacterized protein. (104 aa) |
| | Gen1 | Uncharacterized protein. (210 aa) |
| | rtel1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1042 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa) |
| | ENSHCOP00000023908 | Uncharacterized protein. (105 aa) |
| | lig1 | DNA ligase. (902 aa) |
| | ENSHCOP00000023803 | Uncharacterized protein. (1781 aa) |
| | recql | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (631 aa) |
| | ino80e | INO80 complex subunit E. (236 aa) |
| | ruvbl2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (464 aa) |
| | lig4 | DNA ligase. (910 aa) |
| | rad52 | RAD52 homolog, DNA repair protein. (392 aa) |
| | blm | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (966 aa) |
| | ENSHCOP00000023012 | Uncharacterized protein. (1155 aa) |
| | LOC109508662 | Histone H2A; Belongs to the histone H2A family. (131 aa) |
| | LOC109519106 | Zgc:85936. (1042 aa) |
| | zswim7 | Zinc finger, SWIM-type containing 7. (141 aa) |
| | rag1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1071 aa) |
| | rag2 | Recombination activating gene 2. (534 aa) |
| | DCAF1 | DDB1 and CUL4 associated factor 1. (1477 aa) |
| | rpain | RPA interacting protein. (227 aa) |
| | rad21 | RAD21 cohesin complex component a. (639 aa) |
| | ENSHCOP00000021842 | Rad21_Rec8 domain-containing protein. (76 aa) |
| | xrcc2 | Rad51 domain-containing protein. (353 aa) |
| | uchl5 | Ubiquitin carboxyl-terminal hydrolase. (329 aa) |
| | LOC109515640 | Transcription factor 7. (479 aa) |
| | nsmce4a | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (349 aa) |
| | ENSHCOP00000021185 | Basic leucine zipper transcription factor, ATF-like. (119 aa) |
| | ap5z1 | Adaptor related protein complex 5 subunit zeta 1. (816 aa) |
| | kiaa1841 | Si:ch211-189k9.2. (626 aa) |
| | nabp1 | Nucleic acid binding protein 1a. (169 aa) |
| | cdc45 | CDC45 cell division cycle 45 homolog (S. cerevisiae). (570 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (578 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (726 aa) |
| | msh3 | MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). (1057 aa) |
| | lef1 | Lymphoid enhancer-binding factor 1. (380 aa) |
| | fancb | FA complementation group B. (797 aa) |
| | ruvbl1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (396 aa) |
| | tex11 | Testis expressed 11. (792 aa) |
| | hrob | Si:dkey-260c8.8. (669 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1285 aa) |
| | EME2 | ERCC4 domain-containing protein. (409 aa) |
| | rad51c | RAD51 paralog C. (355 aa) |
| | actr5 | Actin related protein 5; Belongs to the actin family. (595 aa) |
| | ENSHCOP00000018363 | Histone H2A; Belongs to the histone H2A family. (136 aa) |
| | ENSHCOP00000018335 | Zgc:194246. (90 aa) |
| | swi5 | SWI5 homologous recombination repair protein. (138 aa) |
| | actr8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (639 aa) |
| | ino80 | INO80 complex ATPase subunit. (1543 aa) |
| | gins4-2 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa) |
| | LOC109519631 | Chemokine (C-C motif) receptor 6b; Belongs to the G-protein coupled receptor 1 family. (364 aa) |
| | ENSHCOP00000017437 | Uncharacterized protein. (557 aa) |
| | LOC109511934 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (227 aa) |
| | slx4 | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1637 aa) |
| | tfpt | TCF3 (E2A) fusion partner. (198 aa) |
| | LOC109519941 | Calcyon neuron-specific vesicular protein. (202 aa) |
| | nsmce1 | NSE1 homolog, SMC5-SMC6 complex component. (246 aa) |
| | xrcc3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (341 aa) |
| | exo1 | Exonuclease 1. (763 aa) |
| | ppp4c | Serine/threonine-protein phosphatase. (311 aa) |
| | rad51ap1 | RAD51_interact domain-containing protein. (275 aa) |
| | mnd1 | Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (205 aa) |
| | mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (724 aa) |
| | nbn | Nibrin. (832 aa) |
| | rev3l | REV3 like, DNA directed polymerase zeta catalytic subunit. (2836 aa) |
| | rmi2 | RecQ mediated genome instability 2. (158 aa) |
| | mcm9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1028 aa) |
| | ercc4 | Excision repair cross-complementation group 4. (900 aa) |
| | Top2b | TOP4c domain-containing protein. (432 aa) |
| | LOC109532589 | DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (606 aa) |
| | sem1 | SEM1 26S proteasome complex subunit. (95 aa) |
| | LOC109527038 | ATPase family AAA domain containing 5a. (1619 aa) |
| | xrcc1 | X-ray repair complementing defective repair in Chinese hamster cells 1. (612 aa) |
| | hdac10 | Histone deacetylase 10. (663 aa) |
| | msh5 | MutS homolog 5. (819 aa) |
| | fancd2 | FA complementation group D2. (1328 aa) |
| | smc5 | Structural maintenance of chromosomes 5. (1177 aa) |
| | mlh1 | MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (731 aa) |
| | msh4 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (894 aa) |
| | cenpx | Centromere protein X. (81 aa) |
| | mcm3 | DNA helicase; Belongs to the MCM family. (816 aa) |
| | brip1 | BRCA1 interacting protein C-terminal helicase 1. (1000 aa) |
| | ENSHCOP00000001696 | Histone H2A; Belongs to the histone H2A family. (102 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (439 aa) |
| | ENSHCOP00000001235 | Histone H2A; Belongs to the histone H2A family. (133 aa) |
| | LOC109525107 | X-ray repair complementing defective repair in Chinese hamster cells 4. (386 aa) |
| | rec114 | REC114 meiotic recombination protein. (226 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (611 aa) |
| | wdr48 | WD repeat domain 48b. (677 aa) |
| | trip13 | Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (422 aa) |
| | gins2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa) |
| | samhd1 | SAM domain and HD domain 1. (620 aa) |
| | brca1 | Uncharacterized protein. (1141 aa) |
| | LOC109530022 | SWIM-type zinc finger 7 associated protein 1. (268 aa) |
| | Mcm5 | Uncharacterized protein. (57 aa) |
| | Spidr | DUF4503 domain-containing protein. (454 aa) |
| | nsmce2 | SP-RING-type domain-containing protein. (224 aa) |
| | LOC109514706 | Nipped-B protein. (2815 aa) |
| | ENSHCOP00000015108 | PR domain containing 9. (757 aa) |
| | spo11 | SPO11 initiator of meiotic double stranded breaks. (375 aa) |
| | LOC109509643 | Endo/exonuclease/phosphatase domain-containing protein. (194 aa) |
| | ENSHCOP00000014814 | Histone H2A; Belongs to the histone H2A family. (133 aa) |
| | hsf2bp | Heat shock transcription factor 2 binding protein. (352 aa) |
| | ENSHCOP00000014776 | ZnF_Rad18 domain-containing protein. (368 aa) |
| | zfyve26 | Zinc finger, FYVE domain containing 26. (2110 aa) |
| | ENSHCOP00000014556 | Uncharacterized protein. (241 aa) |
| | top2a | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1555 aa) |
| | ercc1 | Excision repair cross-complementation group 1. (338 aa) |
| | xrcc4 | Uncharacterized protein. (263 aa) |
| | pif1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (632 aa) |
| | rnf212b | Si:ch211-10e2.1. (169 aa) |
| | ino80c | INO80 complex subunit C. (192 aa) |
| | msh2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa) |
| | recql4 | RecQ helicase-like 4. (947 aa) |
| | ENSHCOP00000016876 | Histone H2A; Belongs to the histone H2A family. (128 aa) |
| | tprkb | Tp53rk binding protein; Belongs to the CGI121/TPRKB family. (175 aa) |
| | exosc3 | Exosome component 3. (246 aa) |
| | ENSHCOP00000010540 | Helicase, POLQ like. (557 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (285 aa) |
| | rad51b | RAD51 paralog B. (330 aa) |
| | msh6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1375 aa) |
| | LOC109517068 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (572 aa) |
| | mcm6 | DNA helicase; Belongs to the MCM family. (853 aa) |
| | mcm2 | Minichromosome maintenance complex component 2; Belongs to the MCM family. (759 aa) |
| | LOC109514168 | Nipped-B protein. (2434 aa) |
| | Atm | TAN domain-containing protein. (311 aa) |
| | ENSHCOP00000009180 | Uncharacterized protein. (169 aa) |
| | palb2 | PALB2_WD40 domain-containing protein. (1012 aa) |
| | prkdc | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3890 aa) |
