(71 nodes) Endoplasmic reticulum organization network (Hippocampus comes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSHCOP00000002404	Si:dkey-280e21.3. (292 aa)
	polr2m	RNA polymerase II subunit M. (320 aa)
	bnip1	BCL2 interacting protein 1a. (228 aa)
	LOC109516544	Atlastin 3. (502 aa)
	tmed2	Transmembrane p24 trafficking protein 2. (201 aa)
	emc7	ER membrane protein complex subunit 7. (238 aa)
	emc10	ER membrane protein complex subunit 10. (257 aa)
	emc9	ER membrane protein complex subunit 9. (205 aa)
	tram2	Translocating chain-associated membrane protein; Belongs to the TRAM family. (367 aa)
	shtn1	Shootin 1. (431 aa)
	emc6	ER membrane protein complex subunit 6. (110 aa)
	ENSHCOP00000007524	GRAM domain-containing protein. (270 aa)
	get4	Guided entry of tail-anchored proteins factor 4. (323 aa)
	retreg2	Reticulophagy regulator family member 2. (569 aa)
	LOC109507902	Limb and neural patterns a. (394 aa)
	LOC109526246	Transmembrane protein 33. (246 aa)
	emc2	ER membrane protein complex subunit 2. (297 aa)
	camlg	Calcium modulating ligand. (299 aa)
	GET1	Guided entry of tail-anchored proteins factor 1. (170 aa)
	retreg1	Reticulophagy regulator 1. (306 aa)
	esyt2	Extended synaptotagmin-like protein 2b. (838 aa)
	LOC109509358	Ubiquitin-like domain-containing protein. (174 aa)
	get3	ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] (340 aa)
	LOC109531385	Extended synaptotagmin-like protein 1a. (834 aa)
	reep1	Receptor expression-enhancing protein. (300 aa)
	sptssb	Serine palmitoyltransferase, small subunit B. (74 aa)
	mmgt1	Membrane magnesium transporter 1. (127 aa)
	LOC109520418	Lectin, mannose-binding 2-like a. (365 aa)
	cunhxorf56	Zgc:103697. (225 aa)
	vcpip1	Valosin containing protein (p97)/p47 complex interacting protein 1. (1165 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1106 aa)
	ENSHCOP00000010802	Uncharacterized protein. (182 aa)
	emc8	ER membrane protein complex subunit 8. (204 aa)
	LOC109522575	Extended synaptotagmin-like protein 1b. (1553 aa)
	pcnx3	Pecanex 3. (2123 aa)
	LOC109515500	Extended synaptotagmin-like protein 3. (857 aa)
	tmem170a	Transmembrane protein 170A. (137 aa)
	Pcnx2	Uncharacterized protein. (154 aa)
	LOC109522615	SEC31 homolog B, COPII coat complex component. (1210 aa)
	reep2	Receptor expression-enhancing protein. (276 aa)
	LOC109530613	Receptor expression-enhancing protein. (189 aa)
	LOC109510372	ER membrane protein complex subunit 3; Belongs to the EMC3 family. (253 aa)
	lman1	Lectin, mannose-binding, 1. (462 aa)
	LOC109518901	Extended synaptotagmin-like protein 2a. (848 aa)
	wdr83os	WD repeat domain 83 opposite strand. (106 aa)
	tram1	Translocating chain-associated membrane protein; Belongs to the TRAM family. (367 aa)
	bag6	BCL2 associated athanogene 6. (1219 aa)
	lman2	Lectin, mannose-binding 2. (337 aa)
	LOC109522299	ER membrane protein complex subunit 3; Belongs to the EMC3 family. (261 aa)
	ENSHCOP00000013336	Protein kinase domain-containing protein. (472 aa)
	ENSHCOP00000013347	Uncharacterized protein. (1158 aa)
	atl1	Atlastin GTPase 1. (550 aa)
	lpcat3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (480 aa)
	emc1	ER membrane protein complex subunit 1. (966 aa)
	reep3	Receptor expression-enhancing protein. (262 aa)
	pcnx1	Pecanex 1. (2285 aa)
	gramd2a	GRAM domain containing 2A. (274 aa)
	UBL4A	Ubiquitin like 4A. (180 aa)
	LOC109528564	Zgc:113278. (359 aa)
	atl2	Atlastin GTPase 2. (636 aa)
	emc4	ER membrane protein complex subunit 4; Belongs to the EMC4 family. (189 aa)
	sec31a	SEC31 homolog A, COPII coat complex component. (1046 aa)
	LOC109512346	Lunapark, ER junction formation factor. (408 aa)
	Ccdc47	Coiled-coil domain containing 47. (353 aa)
	jagn1	Jagunal homolog 1b. (183 aa)
	LOC109530659	Jagunal homolog 1a. (183 aa)
	sec16a	Protein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (2114 aa)
	ENSHCOP00000018478	Coiled-coil domain containing 47. (426 aa)
	pcnx4	Pecanex 4. (1218 aa)
	LOC109506800	Receptor expression-enhancing protein. (223 aa)
	zfyve27	Zinc finger, FYVE domain containing 27. (417 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ccdc47	LOC109528564	ENSHCOP00000001999	ENSHCOP00000015386	Coiled-coil domain containing 47.	Zgc:113278.	0.477
Ccdc47	emc2	ENSHCOP00000001999	ENSHCOP00000008433	Coiled-coil domain containing 47.	ER membrane protein complex subunit 2.	0.451
Ccdc47	wdr83os	ENSHCOP00000001999	ENSHCOP00000021997	Coiled-coil domain containing 47.	WD repeat domain 83 opposite strand.	0.699
ENSHCOP00000010802	LOC109520418	ENSHCOP00000010802	ENSHCOP00000018959	Uncharacterized protein.	Lectin, mannose-binding 2-like a.	0.497
ENSHCOP00000010802	LOC109522615	ENSHCOP00000010802	ENSHCOP00000025825	Uncharacterized protein.	SEC31 homolog B, COPII coat complex component.	0.833
ENSHCOP00000010802	lman1	ENSHCOP00000010802	ENSHCOP00000023075	Uncharacterized protein.	Lectin, mannose-binding, 1.	0.747
ENSHCOP00000010802	lman2	ENSHCOP00000010802	ENSHCOP00000020298	Uncharacterized protein.	Lectin, mannose-binding 2.	0.497
ENSHCOP00000010802	sec31a	ENSHCOP00000010802	ENSHCOP00000001875	Uncharacterized protein.	SEC31 homolog A, COPII coat complex component.	0.833
ENSHCOP00000010802	tmed2	ENSHCOP00000010802	ENSHCOP00000003400	Uncharacterized protein.	Transmembrane p24 trafficking protein 2.	0.610
ENSHCOP00000013336	ENSHCOP00000013347	ENSHCOP00000013336	ENSHCOP00000013347	Protein kinase domain-containing protein.	Uncharacterized protein.	0.945
ENSHCOP00000013347	ENSHCOP00000013336	ENSHCOP00000013347	ENSHCOP00000013336	Uncharacterized protein.	Protein kinase domain-containing protein.	0.945
ENSHCOP00000018478	LOC109528564	ENSHCOP00000018478	ENSHCOP00000015386	Coiled-coil domain containing 47.	Zgc:113278.	0.477
ENSHCOP00000018478	emc2	ENSHCOP00000018478	ENSHCOP00000008433	Coiled-coil domain containing 47.	ER membrane protein complex subunit 2.	0.451
ENSHCOP00000018478	wdr83os	ENSHCOP00000018478	ENSHCOP00000021997	Coiled-coil domain containing 47.	WD repeat domain 83 opposite strand.	0.699
GET1	LOC109509358	ENSHCOP00000009004	ENSHCOP00000016014	Guided entry of tail-anchored proteins factor 1.	Ubiquitin-like domain-containing protein.	0.432
GET1	LOC109510372	ENSHCOP00000009004	ENSHCOP00000023319	Guided entry of tail-anchored proteins factor 1.	ER membrane protein complex subunit 3; Belongs to the EMC3 family.	0.497
GET1	LOC109522299	ENSHCOP00000009004	ENSHCOP00000019307	Guided entry of tail-anchored proteins factor 1.	ER membrane protein complex subunit 3; Belongs to the EMC3 family.	0.497
GET1	UBL4A	ENSHCOP00000009004	ENSHCOP00000014578	Guided entry of tail-anchored proteins factor 1.	Ubiquitin like 4A.	0.432
GET1	camlg	ENSHCOP00000009004	ENSHCOP00000008609	Guided entry of tail-anchored proteins factor 1.	Calcium modulating ligand.	0.982
GET1	emc6	ENSHCOP00000009004	ENSHCOP00000007403	Guided entry of tail-anchored proteins factor 1.	ER membrane protein complex subunit 6.	0.610