79 items (Hippocampus comes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109509577	Uncharacterized protein. (194 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (433 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (430 aa)
	LOC109525107	X-ray repair complementing defective repair in Chinese hamster cells 4. (386 aa)
	ENSHCOP00000000931	Protein kinase domain-containing protein. (480 aa)
	LOC109513825	Major facilitator superfamily domain containing 11. (441 aa)
	abcg5	ATP-binding cassette, sub-family G (WHITE), member 5. (740 aa)
	topbp1	DNA topoisomerase II binding protein 1. (1350 aa)
	kars1	Lysine--tRNA ligase. (598 aa)
	ENSHCOP00000002481	BCL2 apoptosis regulator b. (221 aa)
	ENSHCOP00000002506	BCL2 apoptosis regulator b. (225 aa)
	LOC109523155	Sirtuin 1. (657 aa)
	fancd2	FA complementation group D2. (1328 aa)
	Rad9b	Uncharacterized protein. (173 aa)
	sfrp2	Secreted frizzled-related protein 2. (299 aa)
	Ikbip	Uncharacterized protein. (387 aa)
	babam1	BRISC and BRCA1 A complex member 1. (373 aa)
	rad51ap1	RAD51_interact domain-containing protein. (275 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1232 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (471 aa)
	ENSHCOP00000006866	Uncharacterized protein. (1585 aa)
	LOC109531265	BRCA1 associated RING domain 1. (783 aa)
	rfwd3	Ring finger and WD repeat domain 3. (697 aa)
	ints3	Integrator complex subunit 3. (1019 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (382 aa)
	xrcc6	X-ray repair complementing defective repair in Chinese hamster cells 6. (609 aa)
	map3k20	Uncharacterized protein. (788 aa)
	men1	Multiple endocrine neoplasia I. (611 aa)
	ENSHCOP00000009180	Uncharacterized protein. (169 aa)
	Atm	TAN domain-containing protein. (311 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (839 aa)
	fbxo4	F-box protein 4. (364 aa)
	ect2	Epithelial cell transforming 2. (848 aa)
	cop1	COP1 E3 ubiquitin ligase. (714 aa)
	LOC109525531	Uncharacterized protein. (324 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa)
	ENSHCOP00000013471	TBD domain-containing protein. (231 aa)
	ENSHCOP00000013487	Uncharacterized protein. (93 aa)
	xrcc4	Uncharacterized protein. (263 aa)
	ercc1	Excision repair cross-complementation group 1. (338 aa)
	ercc8	Excision repair cross-complementation group 8. (384 aa)
	ENSHCOP00000014556	Uncharacterized protein. (241 aa)
	dcun1d3	DCN1-like protein. (326 aa)
	LOC109510758	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	smpd1	Sphingomyelin phosphodiesterase 1, acid lysosomal. (510 aa)
	LOC109517903	Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family. (164 aa)
	Spidr	DUF4503 domain-containing protein. (454 aa)
	itgb6	Integrin beta; Belongs to the integrin beta chain family. (775 aa)
	brca1	Uncharacterized protein. (1141 aa)
	brat1	BRCA1-associated ATM activator 1. (706 aa)
	chek2	Checkpoint kinase 2. (518 aa)
	ino80	INO80 complex ATPase subunit. (1543 aa)
	ENSHCOP00000019285	Deacetylase sirtuin-type domain-containing protein. (166 aa)
	ENSHCOP00000019306	Sirtuin 1. (369 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (578 aa)
	nabp1	Nucleic acid binding protein 1a. (169 aa)
	mfsd11	Uncharacterized protein. (405 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1495 aa)
	inip	Ints3 and nabp interacting protein. (102 aa)
	ENSHCOP00000020910	Uncharacterized protein. (304 aa)
	LOC109508060	Zgc:153993. (204 aa)
	xrcc2	Rad51 domain-containing protein. (353 aa)
	ENSHCOP00000021654	PHD-type domain-containing protein. (341 aa)
	Brcc3	BRCA1/BRCA2-containing complex, subunit 3. (284 aa)
	cdca7l	Cell division cycle associated 7b. (396 aa)
	ENSHCOP00000023012	Uncharacterized protein. (1155 aa)
	babam2	BRISC and BRCA1 A complex member 2. (366 aa)
	blm	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (966 aa)
	rad1	RAD1 homolog (S. pombe). (279 aa)
	lig4	DNA ligase. (910 aa)
	eya3	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (562 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
	abraxas1	Abraxas 1, BRCA1 A complex subunit. (351 aa)
	LOC109521589	Deoxyribonuclease; Belongs to the DNase I family. (272 aa)
	Atr	Uncharacterized protein. (106 aa)
	bax	BCL2 associated X, apoptosis regulator a. (255 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (729 aa)
	rnf168	RING-type domain-containing protein. (444 aa)
	ercc6	Excision repair cross-complementation group 6. (1377 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atm	Atr	ENSHCOP00000009193	ENSHCOP00000025135	TAN domain-containing protein.	Uncharacterized protein.	0.997
Atm	Brcc3	ENSHCOP00000009193	ENSHCOP00000022578	TAN domain-containing protein.	BRCA1/BRCA2-containing complex, subunit 3.	0.641
Atm	ENSHCOP00000009180	ENSHCOP00000009193	ENSHCOP00000009180	TAN domain-containing protein.	Uncharacterized protein.	0.929
Atm	ENSHCOP00000014556	ENSHCOP00000009193	ENSHCOP00000014556	TAN domain-containing protein.	Uncharacterized protein.	0.598
Atm	ENSHCOP00000023012	ENSHCOP00000009193	ENSHCOP00000023012	TAN domain-containing protein.	Uncharacterized protein.	0.887
Atm	LOC109525107	ENSHCOP00000009193	ENSHCOP00000000820	TAN domain-containing protein.	X-ray repair complementing defective repair in Chinese hamster cells 4.	0.467
Atm	LOC109531265	ENSHCOP00000009193	ENSHCOP00000006973	TAN domain-containing protein.	BRCA1 associated RING domain 1.	0.898
Atm	Rad9b	ENSHCOP00000009193	ENSHCOP00000004340	TAN domain-containing protein.	Uncharacterized protein.	0.839
Atm	babam1	ENSHCOP00000009193	ENSHCOP00000005805	TAN domain-containing protein.	BRISC and BRCA1 A complex member 1.	0.630
Atm	babam2	ENSHCOP00000009193	ENSHCOP00000023074	TAN domain-containing protein.	BRISC and BRCA1 A complex member 2.	0.683
Atm	blm	ENSHCOP00000009193	ENSHCOP00000023146	TAN domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.909
Atm	brca1	ENSHCOP00000009193	ENSHCOP00000016663	TAN domain-containing protein.	Uncharacterized protein.	0.968
Atm	cdca7l	ENSHCOP00000009193	ENSHCOP00000022768	TAN domain-containing protein.	Cell division cycle associated 7b.	0.717
Atm	chek2	ENSHCOP00000009193	ENSHCOP00000017184	TAN domain-containing protein.	Checkpoint kinase 2.	0.994
Atm	cop1	ENSHCOP00000009193	ENSHCOP00000011178	TAN domain-containing protein.	COP1 E3 ubiquitin ligase.	0.693
Atm	ercc1	ENSHCOP00000009193	ENSHCOP00000014052	TAN domain-containing protein.	Excision repair cross-complementation group 1.	0.616
Atm	eya3	ENSHCOP00000009193	ENSHCOP00000023772	TAN domain-containing protein.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.612
Atm	fancd2	ENSHCOP00000009193	ENSHCOP00000003317	TAN domain-containing protein.	FA complementation group D2.	0.680
Atm	ints3	ENSHCOP00000009193	ENSHCOP00000007158	TAN domain-containing protein.	Integrator complex subunit 3.	0.407
Atm	lig4	ENSHCOP00000009193	ENSHCOP00000023467	TAN domain-containing protein.	DNA ligase.	0.604