(70 nodes) RNA polymerase II, holoenzyme network (Hippocampus comes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109518943	DNA-directed RNA polymerases I, II, and III subunit RPABC3. (150 aa)
	TAF3	TATA-box binding protein associated factor 3. (654 aa)
	polr2a	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1966 aa)
	myo6	Myosin VIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1251 aa)
	gtf2e2	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (287 aa)
	gtf2a1l	General transcription factor IIA, 1-like. (377 aa)
	LOC109522892	RNA_pol_Rpb5_N domain-containing protein. (127 aa)
	taf5l	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor. (554 aa)
	supt3h	Uncharacterized protein. (340 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (544 aa)
	taf11	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (207 aa)
	gtf2a1	General transcription factor IIA, 1. (388 aa)
	rtf1	RTF1 homolog, Paf1/RNA polymerase II complex component. (679 aa)
	gtf2h4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (441 aa)
	taf12	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (189 aa)
	recql5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (931 aa)
	taf2	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (1103 aa)
	LOC109511949	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (359 aa)
	gtf2f2	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (271 aa)
	ctr9	TPR_REGION domain-containing protein. (1169 aa)
	trrap	Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. (3534 aa)
	ENSHCOP00000001726	Uncharacterized protein. (267 aa)
	mnat1	MNAT1 component of CDK activating kinase. (289 aa)
	cdc73	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (547 aa)
	polr2m	RNA polymerase II subunit M. (320 aa)
	gtf2f1	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (491 aa)
	LOC109512496	Transcription initiation factor TFIID subunit. (2074 aa)
	polr2f	Polymerase (RNA) II (DNA directed) polypeptide F. (127 aa)
	Gtf2a2	TFIIA_gamma_N domain-containing protein. (152 aa)
	polr2d	Polymerase (RNA) II (DNA directed) polypeptide D. (142 aa)
	polr2c	Polymerase (RNA) II (DNA directed) polypeptide C. (275 aa)
	Wdr61	WD repeat domain 61. (109 aa)
	LOC109524819	Myosin VIa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1300 aa)
	LOC109518249	TAFH domain-containing protein. (557 aa)
	polr2g	Polymerase (RNA) II (DNA directed) polypeptide G-like. (189 aa)
	ENSHCOP00000007641	Uncharacterized protein. (208 aa)
	taf6l	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor. (601 aa)
	LOC109519125	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	polr2i	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
	LOC109517330	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (246 aa)
	pex2	Peroxisomal biogenesis factor 2. (313 aa)
	LOC109531617	Regulation of nuclear pre-mRNA domain containing 1A. (294 aa)
	polr2b	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
	ENSHCOP00000011287	CID domain-containing protein. (67 aa)
	LOC109522781	Regulation of nuclear pre-mRNA domain containing 2b. (781 aa)
	gtf2h5	General transcription factor IIH, polypeptide 5. (71 aa)
	tbp	TATA box binding protein. (308 aa)
	gtf2h3	General transcription factor IIH, polypeptide 3. (299 aa)
	polr2j	Polymerase (RNA) II (DNA directed) polypeptide J. (172 aa)
	LOC109506821	General transcription factor IIH subunit. (376 aa)
	ercc2	Excision repair cross-complementation group 2. (591 aa)
	taf5	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (747 aa)
	polr2k	Polymerase (RNA) II (DNA directed) polypeptide K. (58 aa)
	ercc3	Excision repair cross-complementation group 3. (782 aa)
	ccnh	Cyclin H; Belongs to the cyclin family. (320 aa)
	taf10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (188 aa)
	rprd1b	Regulation of nuclear pre-mRNA domain containing 1B. (330 aa)
	gtf2e1	General transcription factor IIE, polypeptide 1, alpha. (492 aa)
	LOC109523329	General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (262 aa)
	rpap2	RNA polymerase II associated protein 2. (654 aa)
	gtf2b	General transcription factor IIB. (224 aa)
	POLR2E	RNA polymerase II subunit E. (210 aa)
	LOC109513977	TAFH domain-containing protein. (907 aa)
	leo1	LEO1 homolog, Paf1/RNA polymerase II complex component. (657 aa)
	paf1	PAF1 homolog, Paf1/RNA polymerase II complex component. (529 aa)
	taf6	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (637 aa)
	taf4	TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor. (746 aa)
	taf13	TATA-box binding protein associated factor 13. (124 aa)
	taf8	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (308 aa)
	polr2l	Polymerase (RNA) II (DNA directed) polypeptide L. (67 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHCOP00000001726	LOC109511949	ENSHCOP00000001726	ENSHCOP00000000252	Uncharacterized protein.	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.567
ENSHCOP00000001726	LOC109517330	ENSHCOP00000001726	ENSHCOP00000009399	Uncharacterized protein.	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.974
ENSHCOP00000001726	supt3h	ENSHCOP00000001726	ENSHCOP00000028138	Uncharacterized protein.	Uncharacterized protein.	0.959
ENSHCOP00000001726	taf10	ENSHCOP00000001726	ENSHCOP00000014098	Uncharacterized protein.	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.974
ENSHCOP00000001726	taf12	ENSHCOP00000001726	ENSHCOP00000025500	Uncharacterized protein.	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.961
ENSHCOP00000001726	taf5	ENSHCOP00000001726	ENSHCOP00000012918	Uncharacterized protein.	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.909
ENSHCOP00000001726	taf5l	ENSHCOP00000001726	ENSHCOP00000028421	Uncharacterized protein.	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor.	0.909
ENSHCOP00000001726	taf6	ENSHCOP00000001726	ENSHCOP00000019381	Uncharacterized protein.	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.953
ENSHCOP00000001726	taf6l	ENSHCOP00000001726	ENSHCOP00000008081	Uncharacterized protein.	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor.	0.938
ENSHCOP00000001726	tbp	ENSHCOP00000001726	ENSHCOP00000011609	Uncharacterized protein.	TATA box binding protein.	0.686
ENSHCOP00000001726	trrap	ENSHCOP00000001726	ENSHCOP00000001677	Uncharacterized protein.	Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family.	0.929
ENSHCOP00000007641	ENSHCOP00000011287	ENSHCOP00000007641	ENSHCOP00000011287	Uncharacterized protein.	CID domain-containing protein.	0.660
ENSHCOP00000007641	Gtf2a2	ENSHCOP00000007641	ENSHCOP00000004691	Uncharacterized protein.	TFIIA_gamma_N domain-containing protein.	0.960
ENSHCOP00000007641	LOC109506821	ENSHCOP00000007641	ENSHCOP00000011910	Uncharacterized protein.	General transcription factor IIH subunit.	0.954
ENSHCOP00000007641	LOC109511949	ENSHCOP00000007641	ENSHCOP00000000252	Uncharacterized protein.	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.790
ENSHCOP00000007641	LOC109512496	ENSHCOP00000007641	ENSHCOP00000004456	Uncharacterized protein.	Transcription initiation factor TFIID subunit.	0.886
ENSHCOP00000007641	LOC109513977	ENSHCOP00000007641	ENSHCOP00000017359	Uncharacterized protein.	TAFH domain-containing protein.	0.661
ENSHCOP00000007641	LOC109517330	ENSHCOP00000007641	ENSHCOP00000009399	Uncharacterized protein.	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.791
ENSHCOP00000007641	LOC109518249	ENSHCOP00000007641	ENSHCOP00000007233	Uncharacterized protein.	TAFH domain-containing protein.	0.661
ENSHCOP00000007641	LOC109518943	ENSHCOP00000007641	ENSHCOP00000022537	Uncharacterized protein.	DNA-directed RNA polymerases I, II, and III subunit RPABC3.	0.943