53 items (Hippocampus comes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (611 aa)
	patl1	PAT1 homolog 1, processing body mRNA decay factor. (823 aa)
	topbp1	DNA topoisomerase II binding protein 1. (1350 aa)
	rnf111	Ring finger protein 111. (1022 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2512 aa)
	ENSHCOP00000002511	RING-type domain-containing protein. (152 aa)
	smc5	Structural maintenance of chromosomes 5. (1177 aa)
	LOC109523155	Sirtuin 1. (657 aa)
	LOC109515828	Germ cell nuclear acidic peptidase. (619 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (282 aa)
	ENSHCOP00000005103	Uncharacterized protein. (167 aa)
	ENSHCOP00000006938	Uncharacterized protein. (399 aa)
	rfwd3	Ring finger and WD repeat domain 3. (697 aa)
	smc6	Si:dkey-119f1.1. (1086 aa)
	sumo1	Small ubiquitin-related modifier. (101 aa)
	tp53inp2	Uncharacterized protein. (314 aa)
	LOC109517068	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (572 aa)
	klhl20	Kelch-like family member 20. (609 aa)
	sqstm1	Sequestosome 1. (407 aa)
	LOC109516616	RING-type domain-containing protein. (822 aa)
	ENSHCOP00000011529	SKI proto-oncogene. (235 aa)
	ski	V-ski avian sarcoma viral oncogene homolog a. (730 aa)
	ppargc1a	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (915 aa)
	CIITA	Class II major histocompatibility complex transactivator. (1134 aa)
	mlip	Uncharacterized protein. (792 aa)
	LOC109530839	Thymine DNA glycosylase, tandem duplicate 1. (383 aa)
	LOC109525236	Uncharacterized protein. (324 aa)
	ankrd1	Ankyrin repeat domain 1a (cardiac muscle). (320 aa)
	nsmce2	SP-RING-type domain-containing protein. (224 aa)
	LOC109512681	RING-type domain-containing protein. (553 aa)
	LOC109531349	Nuclear factor, erythroid 2. (479 aa)
	ENSHCOP00000016272	Uncharacterized protein. (1636 aa)
	chek2	Checkpoint kinase 2. (518 aa)
	daxx	Daxx domain-containing protein. (492 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1111 aa)
	chfr	Checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase. (632 aa)
	Topors	Topoisomerase I binding, arginine/serine-rich a. (655 aa)
	ENSHCOP00000019285	Deacetylase sirtuin-type domain-containing protein. (166 aa)
	ENSHCOP00000019306	Sirtuin 1. (369 aa)
	Morc3	Uncharacterized protein. (167 aa)
	top3a	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (726 aa)
	rb1	Retinoblastoma 1. (903 aa)
	atrx	ATRX chromatin remodeler. (1645 aa)
	rpain	RPA interacting protein. (227 aa)
	blm	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (966 aa)
	n4bp1	Nedd4 binding protein 1. (970 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
	rnf4	Ring finger protein 4. (208 aa)
	Atr	Uncharacterized protein. (106 aa)
	LOC109516174	Tripartite motif containing 8b. (583 aa)
	patl2	PAT1 homolog 2. (705 aa)
	LOC109530840	Thymine DNA glycosylase, tandem duplicate 2. (446 aa)
	tdp2	Tyrosyl-DNA phosphodiesterase 2b. (367 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atr	LOC109517068	ENSHCOP00000025135	ENSHCOP00000009787	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.964
Atr	blm	ENSHCOP00000025135	ENSHCOP00000023146	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.973
Atr	chek2	ENSHCOP00000025135	ENSHCOP00000017184	Uncharacterized protein.	Checkpoint kinase 2.	0.996
Atr	mtor	ENSHCOP00000025135	ENSHCOP00000002338	Uncharacterized protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.467
Atr	nsmce2	ENSHCOP00000025135	ENSHCOP00000015514	Uncharacterized protein.	SP-RING-type domain-containing protein.	0.645
Atr	rad51	ENSHCOP00000025135	ENSHCOP00000024035	Uncharacterized protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.909
Atr	rfwd3	ENSHCOP00000025135	ENSHCOP00000007085	Uncharacterized protein.	Ring finger and WD repeat domain 3.	0.530
Atr	rpa1	ENSHCOP00000025135	ENSHCOP00000000570	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.964
Atr	smc5	ENSHCOP00000025135	ENSHCOP00000003098	Uncharacterized protein.	Structural maintenance of chromosomes 5.	0.746
Atr	smc6	ENSHCOP00000025135	ENSHCOP00000007176	Uncharacterized protein.	Si:dkey-119f1.1.	0.686
Atr	top3a	ENSHCOP00000025135	ENSHCOP00000019422	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.819
Atr	topbp1	ENSHCOP00000025135	ENSHCOP00000001438	Uncharacterized protein.	DNA topoisomerase II binding protein 1.	0.984
ENSHCOP00000002511	Topors	ENSHCOP00000002511	ENSHCOP00000018815	RING-type domain-containing protein.	Topoisomerase I binding, arginine/serine-rich a.	0.874
ENSHCOP00000002511	sumo1	ENSHCOP00000002511	ENSHCOP00000008810	RING-type domain-containing protein.	Small ubiquitin-related modifier.	0.635
ENSHCOP00000005103	blm	ENSHCOP00000005103	ENSHCOP00000023146	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.415
ENSHCOP00000005103	daxx	ENSHCOP00000005103	ENSHCOP00000017688	Uncharacterized protein.	Daxx domain-containing protein.	0.975
ENSHCOP00000005103	rad51	ENSHCOP00000005103	ENSHCOP00000024035	Uncharacterized protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.815
ENSHCOP00000005103	smc5	ENSHCOP00000005103	ENSHCOP00000003098	Uncharacterized protein.	Structural maintenance of chromosomes 5.	0.569
ENSHCOP00000005103	sumo1	ENSHCOP00000005103	ENSHCOP00000008810	Uncharacterized protein.	Small ubiquitin-related modifier.	0.443
ENSHCOP00000006938	sqstm1	ENSHCOP00000006938	ENSHCOP00000010793	Uncharacterized protein.	Sequestosome 1.	0.814