(58 nodes) SCF ubiquitin ligase complex network (Hippocampus comes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fbxl20	F-box and leucine-rich repeat protein 20. (436 aa)
	ENSHCOP00000004583	F-box domain-containing protein. (403 aa)
	fbxl12	F-box domain-containing protein. (413 aa)
	LOC109512957	Si:rp71-1k13.6. (319 aa)
	tmem183a	Transmembrane protein 183A. (359 aa)
	fbxl3	F-box and leucine-rich repeat protein 3a. (435 aa)
	fbxw4	F-box and WD repeat domain containing 4. (392 aa)
	fbxl16	F-box and leucine-rich repeat protein 16. (497 aa)
	fbxl18	F-box and leucine-rich repeat protein 18. (720 aa)
	fbxw8	F-box and WD repeat domain containing 8. (633 aa)
	ENSHCOP00000008529	FBA domain-containing protein. (100 aa)
	LOC109523919	SplA/ryanodine receptor domain and SOCS box containing 3b. (353 aa)
	LOC109514645	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (77 aa)
	LOC109513724	Uncharacterized protein. (831 aa)
	cul2	Cullin 2; Belongs to the cullin family. (725 aa)
	Fbxl7	Si:dkey-192l18.9. (425 aa)
	daw1	Dynein assembly factor with WDR repeat domains 1. (401 aa)
	fbxo15	Uncharacterized protein. (375 aa)
	fbxo32	F-box protein 32. (354 aa)
	LOC109524622	F-box domain-containing protein. (431 aa)
	LOC109527158	SplA/ryanodine receptor domain and SOCS box containing 4a. (286 aa)
	skp2	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (425 aa)
	nccrp1	Non-specific cytotoxic cell receptor protein 1. (233 aa)
	cacybp	Calcyclin binding protein. (228 aa)
	fbxl4	F-box and leucine-rich repeat protein 4. (614 aa)
	rbx1	Ring-box 1, E3 ubiquitin protein ligase. (181 aa)
	ENSHCOP00000011234	Uncharacterized protein. (199 aa)
	fbxo4	F-box protein 4. (364 aa)
	LOC109521568	FBA domain-containing protein. (176 aa)
	fbxl17	F-box and leucine-rich repeat protein 17. (607 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1363 aa)
	Fbxl15	F-box and leucine-rich repeat protein 15. (284 aa)
	ENSHCOP00000027605	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	dmac2	Si:ch1073-228b5.2. (241 aa)
	ccnf	Cyclin F; Belongs to the cyclin family. (792 aa)
	fbxl22	F-box and leucine-rich repeat protein 22. (229 aa)
	ENSHCOP00000008605	F-box domain-containing protein. (729 aa)
	fbxo45	F-box protein 45. (287 aa)
	spsb4	SplA/ryanodine receptor domain and SOCS box containing 4a. (278 aa)
	fbxo9	F-box protein 9. (400 aa)
	FBXL14	F-box and leucine rich repeat protein 14. (416 aa)
	LOC109514887	SplA/ryanodine receptor domain and SOCS box containing 3a. (369 aa)
	fbxo33	F-box protein 33. (490 aa)
	LOC109526808	Leucine rich repeat containing 29. (626 aa)
	LOC109526763	F-box and leucine-rich repeat protein 14a. (403 aa)
	fbxw11	F-box and WD repeat domain containing 11b. (527 aa)
	fbxo31	F-box protein 31. (538 aa)
	fbxo25	F-box protein 25. (354 aa)
	fbxl5	F-box and leucine-rich repeat protein 5. (690 aa)
	cul1	Cullin 1b; Belongs to the cullin family. (776 aa)
	fbxo7	F-box protein 7. (443 aa)
	skp1	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
	fbxo42	F-box protein 42. (704 aa)
	spsb1	SplA/ryanodine receptor domain and SOCS box containing 1. (272 aa)
	LOC109518392	F-box and leucine-rich repeat protein 2. (415 aa)
	fbxw5	F-box and WD repeat domain containing 5. (607 aa)
	ENSHCOP00000003819	Si:ch1073-228j22.2. (122 aa)
	fbxl6	F-box domain-containing protein. (550 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHCOP00000003819	LOC109514887	ENSHCOP00000003819	ENSHCOP00000024916	Si:ch1073-228j22.2.	SplA/ryanodine receptor domain and SOCS box containing 3a.	0.442
ENSHCOP00000003819	cul1	ENSHCOP00000003819	ENSHCOP00000010060	Si:ch1073-228j22.2.	Cullin 1b; Belongs to the cullin family.	0.557
ENSHCOP00000003819	cul2	ENSHCOP00000003819	ENSHCOP00000016422	Si:ch1073-228j22.2.	Cullin 2; Belongs to the cullin family.	0.441
ENSHCOP00000003819	rbx1	ENSHCOP00000003819	ENSHCOP00000011377	Si:ch1073-228j22.2.	Ring-box 1, E3 ubiquitin protein ligase.	0.438
ENSHCOP00000003819	skp1	ENSHCOP00000003819	ENSHCOP00000021362	Si:ch1073-228j22.2.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.692
ENSHCOP00000004583	cul1	ENSHCOP00000004583	ENSHCOP00000010060	F-box domain-containing protein.	Cullin 1b; Belongs to the cullin family.	0.585
ENSHCOP00000004583	cul2	ENSHCOP00000004583	ENSHCOP00000016422	F-box domain-containing protein.	Cullin 2; Belongs to the cullin family.	0.402
ENSHCOP00000004583	rbx1	ENSHCOP00000004583	ENSHCOP00000011377	F-box domain-containing protein.	Ring-box 1, E3 ubiquitin protein ligase.	0.498
ENSHCOP00000004583	skp1	ENSHCOP00000004583	ENSHCOP00000021362	F-box domain-containing protein.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.936
ENSHCOP00000008529	cul1	ENSHCOP00000008529	ENSHCOP00000010060	FBA domain-containing protein.	Cullin 1b; Belongs to the cullin family.	0.732
ENSHCOP00000008529	rbx1	ENSHCOP00000008529	ENSHCOP00000011377	FBA domain-containing protein.	Ring-box 1, E3 ubiquitin protein ligase.	0.563
ENSHCOP00000008529	skp1	ENSHCOP00000008529	ENSHCOP00000021362	FBA domain-containing protein.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.885
ENSHCOP00000008605	cul1	ENSHCOP00000008605	ENSHCOP00000010060	F-box domain-containing protein.	Cullin 1b; Belongs to the cullin family.	0.812
ENSHCOP00000008605	fbxo4	ENSHCOP00000008605	ENSHCOP00000010965	F-box domain-containing protein.	F-box protein 4.	0.407
ENSHCOP00000008605	fbxo9	ENSHCOP00000008605	ENSHCOP00000012743	F-box domain-containing protein.	F-box protein 9.	0.407
ENSHCOP00000008605	rbx1	ENSHCOP00000008605	ENSHCOP00000011377	F-box domain-containing protein.	Ring-box 1, E3 ubiquitin protein ligase.	0.664
ENSHCOP00000008605	skp1	ENSHCOP00000008605	ENSHCOP00000021362	F-box domain-containing protein.	S-phase kinase-associated protein 1; Belongs to the SKP1 family.	0.993
ENSHCOP00000011234	cul1	ENSHCOP00000011234	ENSHCOP00000010060	Uncharacterized protein.	Cullin 1b; Belongs to the cullin family.	0.955
ENSHCOP00000011234	fbxl17	ENSHCOP00000011234	ENSHCOP00000002308	Uncharacterized protein.	F-box and leucine-rich repeat protein 17.	0.900
ENSHCOP00000011234	rbx1	ENSHCOP00000011234	ENSHCOP00000011377	Uncharacterized protein.	Ring-box 1, E3 ubiquitin protein ligase.	0.772