62 items (Hippocampus comes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109517738	V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Gb. (156 aa)
	ENSHCOP00000000611	Mesoderm posterior ba. (146 aa)
	nkx6-3	NK6 homeobox 3. (270 aa)
	LOC109512344	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (787 aa)
	LOC109514565	Grainyhead-like transcription factor 2b. (598 aa)
	LOC109515798	COMM domain containing 5. (211 aa)
	ENSHCOP00000002881	Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (314 aa)
	LOC109512449	F11 receptor, tandem duplicate 1. (273 aa)
	LOC109525693	Keratinocyte differentiation factor 1a. (361 aa)
	cldn5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa)
	TMEM100	Transmembrane protein 100. (141 aa)
	LOC109526430	Bone morphogenetic protein 16. (439 aa)
	LOC109516855	T-cell acute lymphocytic leukemia 1. (387 aa)
	ENSHCOP00000007650	Sprouty RTK signaling antagonist 2. (283 aa)
	ENSHCOP00000007987	CCAAT enhancer binding protein beta. (289 aa)
	LOC109517857	H2A histone family, member Y; Belongs to the histone H2A family. (369 aa)
	ENSHCOP00000009146	Abelson helper integration site 1. (838 aa)
	btg1	B-cell translocation gene 1, anti-proliferative. (182 aa)
	proc	Uncharacterized protein. (439 aa)
	ENSHCOP00000010561	Apolipoprotein L, 1. (326 aa)
	LOC109516535	Uncharacterized protein. (1194 aa)
	LOC109523437	LIM homeobox 1a. (407 aa)
	bad	Uncharacterized protein. (173 aa)
	tp63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (544 aa)
	numa1	Uncharacterized protein. (1815 aa)
	LOC109513432	Interleukin-1. (238 aa)
	LOC109516252	Vinculin a. (1066 aa)
	S1pr2	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (348 aa)
	LOC109517881	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (116 aa)
	LOC109514730	Inhibitor_Mig-6 domain-containing protein. (340 aa)
	gdnf	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (257 aa)
	rock1	Rho-associated, coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1333 aa)
	LOC109515323	Tumor necrosis factor receptor superfamily, member 1a. (383 aa)
	hhex	Homeobox domain-containing protein. (320 aa)
	ptch1	Patched 1. (1395 aa)
	cited1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1. (168 aa)
	ENSHCOP00000016441	ERBB receptor feedback inhibitor 1a. (275 aa)
	bmp4	Bone morphogenetic protein 4. (350 aa)
	LOC109519402	Uncharacterized protein. (290 aa)
	LOC109514598	Keratinocyte differentiation factor 1b. (355 aa)
	ENSHCOP00000018446	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (75 aa)
	id1	Inhibitor of DNA binding 1, HLH protein. (132 aa)
	frzb	Frizzled related protein. (314 aa)
	gata3	GATA binding protein 3. (450 aa)
	serpine1	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (392 aa)
	ajap1	Adherens junctions associated protein 1. (385 aa)
	LOC109528912	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (143 aa)
	LOC109509080	TGF_BETA_2 domain-containing protein. (247 aa)
	LOC109528735	Kruppel like factor 7. (239 aa)
	rock2	Rho-associated, coiled-coil containing protein kinase 2a; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1338 aa)
	zdhhc21	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
	ENSHCOP00000024133	Si:rp71-1g18.13. (283 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (808 aa)
	MAFG	MAF bZIP transcription factor G. (143 aa)
	vcl	Vinculin b. (1066 aa)
	grhl1	Grainyhead-like transcription factor 1. (615 aa)
	krit1	KRIT1 ankyrin repeat containing. (742 aa)
	LOC109522745	H2A histone family, member Y2; Belongs to the histone H2A family. (418 aa)
	foxn1	Forkhead box N1. (370 aa)
	spred3	Sprouty related EVH1 domain containing 3. (504 aa)
	prkx	Protein kinase X-linked; Belongs to the protein kinase superfamily. (349 aa)
	tp73	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (571 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHCOP00000002881	ENSHCOP00000007650	ENSHCOP00000002881	ENSHCOP00000007650	Sprouty homolog 1, antagonist of FGF signaling (Drosophila).	Sprouty RTK signaling antagonist 2.	0.622
ENSHCOP00000007650	ENSHCOP00000002881	ENSHCOP00000007650	ENSHCOP00000002881	Sprouty RTK signaling antagonist 2.	Sprouty homolog 1, antagonist of FGF signaling (Drosophila).	0.622
ENSHCOP00000018446	LOC109509080	ENSHCOP00000018446	ENSHCOP00000021950	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	TGF_BETA_2 domain-containing protein.	0.500
ENSHCOP00000018446	bmp4	ENSHCOP00000018446	ENSHCOP00000016989	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Bone morphogenetic protein 4.	0.500
LOC109509080	ENSHCOP00000018446	ENSHCOP00000021950	ENSHCOP00000018446	TGF_BETA_2 domain-containing protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.500
LOC109509080	LOC109517881	ENSHCOP00000021950	ENSHCOP00000013552	TGF_BETA_2 domain-containing protein.	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.524
LOC109509080	LOC109528912	ENSHCOP00000021950	ENSHCOP00000021451	TGF_BETA_2 domain-containing protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.524
LOC109509080	bmp4	ENSHCOP00000021950	ENSHCOP00000016989	TGF_BETA_2 domain-containing protein.	Bone morphogenetic protein 4.	0.901
LOC109512344	LOC109512449	ENSHCOP00000002015	ENSHCOP00000003294	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	F11 receptor, tandem duplicate 1.	0.478
LOC109512344	LOC109516252	ENSHCOP00000002015	ENSHCOP00000013162	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Vinculin a.	0.612
LOC109512344	cldn5	ENSHCOP00000002015	ENSHCOP00000004437	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.797
LOC109512344	krit1	ENSHCOP00000002015	ENSHCOP00000025603	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	KRIT1 ankyrin repeat containing.	0.471
LOC109512344	vcl	ENSHCOP00000002015	ENSHCOP00000025459	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Vinculin b.	0.612
LOC109512449	LOC109512344	ENSHCOP00000003294	ENSHCOP00000002015	F11 receptor, tandem duplicate 1.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.478
LOC109512449	cldn5	ENSHCOP00000003294	ENSHCOP00000004437	F11 receptor, tandem duplicate 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.624
LOC109513432	LOC109515323	ENSHCOP00000012063	ENSHCOP00000014336	Interleukin-1.	Tumor necrosis factor receptor superfamily, member 1a.	0.748
LOC109513432	cldn5	ENSHCOP00000012063	ENSHCOP00000004437	Interleukin-1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.579
LOC109513432	serpine1	ENSHCOP00000012063	ENSHCOP00000019329	Interleukin-1.	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.	0.400
LOC109515323	LOC109513432	ENSHCOP00000014336	ENSHCOP00000012063	Tumor necrosis factor receptor superfamily, member 1a.	Interleukin-1.	0.748
LOC109516252	LOC109512344	ENSHCOP00000013162	ENSHCOP00000002015	Vinculin a.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.612