58 items (Hippocampus comes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cul4a	Cullin 4A; Belongs to the cullin family. (749 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (430 aa)
	tmem161a	Transmembrane protein 161A. (487 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1363 aa)
	mettl3	Methyltransferase like 3; Belongs to the MT-A70-like family. (575 aa)
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (966 aa)
	LOC109507207	Opsin 8, group member b; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (339 aa)
	LOC109510475	Mitogen-activated protein kinase. (360 aa)
	LOC109523155	Sirtuin 1. (657 aa)
	eif2s1	Eukaryotic translation initiation factor 2, subunit 1 alpha b. (315 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (282 aa)
	opn3	Opsin 3. (385 aa)
	noc2l	NOC2-like nucleolar associated transcriptional repressor. (760 aa)
	casp9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (477 aa)
	xpc	Xeroderma pigmentosum, complementation group C. (859 aa)
	zbtb1	Zinc finger and BTB domain containing 1. (626 aa)
	LOC109531756	Opsin 5; Belongs to the G-protein coupled receptor 1 family. (334 aa)
	ENSHCOP00000006047	Uncharacterized protein. (205 aa)
	LOC109532526	Uncharacterized protein. (1579 aa)
	ENSHCOP00000006772	Uncharacterized protein. (615 aa)
	LOC109522222	Mitogen-activated protein kinase. (449 aa)
	LOC109512841	E1A binding protein p300 a. (2561 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (437 aa)
	cops9	COP9 signalosome subunit 9. (57 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (839 aa)
	LOC109524107	Nuclear factor of activated T cells 4. (805 aa)
	Polk	Polymerase (DNA directed) kappa. (396 aa)
	cul4b	Cullin 4B; Belongs to the cullin family. (772 aa)
	ercc1	Excision repair cross-complementation group 1. (338 aa)
	ENSHCOP00000014556	Uncharacterized protein. (241 aa)
	aqp1	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (259 aa)
	smpd1	Sphingomyelin phosphodiesterase 1, acid lysosomal. (510 aa)
	ddb1	Damage-specific DNA binding protein 1. (1093 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1478 aa)
	xpa	Xeroderma pigmentosum, complementation group A. (279 aa)
	LOC109527342	CREB binding protein a. (2447 aa)
	ino80	INO80 complex ATPase subunit. (1543 aa)
	LOC109512331	UmuC domain-containing protein. (184 aa)
	actr5	Actin related protein 5; Belongs to the actin family. (595 aa)
	ENSHCOP00000019285	Deacetylase sirtuin-type domain-containing protein. (166 aa)
	ENSHCOP00000019306	Sirtuin 1. (369 aa)
	LOC109515948	Aurora kinase B; Belongs to the protein kinase superfamily. (330 aa)
	LOC109508060	Zgc:153993. (204 aa)
	LOC109532549	CREB binding protein b. (1735 aa)
	ppid	Peptidylprolyl isomerase D. (375 aa)
	parp1	Poly [ADP-ribose] polymerase. (1020 aa)
	LOC109514850	E1A binding protein p300 b. (2669 aa)
	pold1	DNA polymerase. (1105 aa)
	Atr	Uncharacterized protein. (106 aa)
	ercc4	Excision repair cross-complementation group 4. (900 aa)
	LOC109526648	Mitogen-activated protein kinase. (354 aa)
	Mc1r	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (322 aa)
	impact	Impact RWD domain protein. (312 aa)
	bax	BCL2 associated X, apoptosis regulator a. (255 aa)
	polh	Polymerase (DNA directed), eta. (483 aa)
	bmf	Bcl2 modifying factor. (135 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (462 aa)
	rhbdd1	Rhomboid domain containing 1. (328 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atr	ENSHCOP00000014556	ENSHCOP00000025135	ENSHCOP00000014556	Uncharacterized protein.	Uncharacterized protein.	0.639
Atr	chek1	ENSHCOP00000025135	ENSHCOP00000027175	Uncharacterized protein.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.998
Atr	ercc1	ENSHCOP00000025135	ENSHCOP00000014052	Uncharacterized protein.	Excision repair cross-complementation group 1.	0.721
Atr	ercc4	ENSHCOP00000025135	ENSHCOP00000025158	Uncharacterized protein.	Excision repair cross-complementation group 4.	0.826
Atr	pold1	ENSHCOP00000025135	ENSHCOP00000024706	Uncharacterized protein.	DNA polymerase.	0.494
Atr	xpa	ENSHCOP00000025135	ENSHCOP00000016946	Uncharacterized protein.	Xeroderma pigmentosum, complementation group A.	0.581
Atr	xpc	ENSHCOP00000025135	ENSHCOP00000005278	Uncharacterized protein.	Xeroderma pigmentosum, complementation group C.	0.667
EIF2AK4	eif2s1	ENSHCOP00000015164	ENSHCOP00000003762	Eukaryotic translation initiation factor 2 alpha kinase 4.	Eukaryotic translation initiation factor 2, subunit 1 alpha b.	0.990
EIF2AK4	impact	ENSHCOP00000015164	ENSHCOP00000025972	Eukaryotic translation initiation factor 2 alpha kinase 4.	Impact RWD domain protein.	0.408
ENSHCOP00000006047	LOC109508060	ENSHCOP00000006047	ENSHCOP00000020948	Uncharacterized protein.	Zgc:153993.	0.519
ENSHCOP00000006047	bax	ENSHCOP00000006047	ENSHCOP00000026539	Uncharacterized protein.	BCL2 associated X, apoptosis regulator a.	0.416
ENSHCOP00000006772	ENSHCOP00000019285	ENSHCOP00000006772	ENSHCOP00000019285	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.400
ENSHCOP00000006772	ENSHCOP00000019306	ENSHCOP00000006772	ENSHCOP00000019306	Uncharacterized protein.	Sirtuin 1.	0.400
ENSHCOP00000006772	LOC109512841	ENSHCOP00000006772	ENSHCOP00000007909	Uncharacterized protein.	E1A binding protein p300 a.	0.854
ENSHCOP00000006772	LOC109514850	ENSHCOP00000006772	ENSHCOP00000024673	Uncharacterized protein.	E1A binding protein p300 b.	0.854
ENSHCOP00000006772	LOC109523155	ENSHCOP00000006772	ENSHCOP00000003219	Uncharacterized protein.	Sirtuin 1.	0.400
ENSHCOP00000006772	LOC109532549	ENSHCOP00000006772	ENSHCOP00000021630	Uncharacterized protein.	CREB binding protein b.	0.925
ENSHCOP00000006772	kdm1a	ENSHCOP00000006772	ENSHCOP00000010393	Uncharacterized protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.477
ENSHCOP00000006772	xpa	ENSHCOP00000006772	ENSHCOP00000016946	Uncharacterized protein.	Xeroderma pigmentosum, complementation group A.	0.537
ENSHCOP00000014556	Atr	ENSHCOP00000014556	ENSHCOP00000025135	Uncharacterized protein.	Uncharacterized protein.	0.639