(86 nodes) Endocrine system development network (Hippocampus comes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	arx	Aristaless related homeobox a. (455 aa)
	ENSHCOP00000023388	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (407 aa)
	cdkal1	CDK5 regulatory subunit associated protein 1-like 1. (519 aa)
	fitm2	Fat storage inducing transmembrane protein 2. (293 aa)
	LOC109523037	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	gcm2	GCM domain-containing protein. (436 aa)
	LOC109523017	Homeobox protein. (291 aa)
	LOC109528912	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (143 aa)
	disp1	Dispatched homolog 1 (Drosophila). (1573 aa)
	med12	Mediator complex subunit 12. (2112 aa)
	ENSHCOP00000021111	T-box transcription factor 2a. (360 aa)
	LOC109529023	Uncharacterized protein. (560 aa)
	LOC109508060	Zgc:153993. (204 aa)
	INSM1	INSM transcriptional repressor 1. (318 aa)
	LOC109523016	Homeobox domain-containing protein. (231 aa)
	neurod1	Neuronal differentiation 1. (358 aa)
	pax8	Paired box 8. (445 aa)
	GCG	Glucagon. (169 aa)
	ENSHCOP00000018446	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (75 aa)
	dkk3	Dickkopf WNT signaling pathway inhibitor 3a. (220 aa)
	hand2	Heart and neural crest derivatives expressed 2. (203 aa)
	gsx1	GS homeobox 1. (245 aa)
	six3	SIX homeobox 3a. (294 aa)
	srf	Serum response factor b. (601 aa)
	hnf1b	HNF1 homeobox Ba. (629 aa)
	hhex	Homeobox domain-containing protein. (320 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (250 aa)
	LOC109517881	IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (116 aa)
	Nkx2-2	NK2 homeobox 2a. (255 aa)
	LOC109520029	WT1 transcription factor a. (416 aa)
	pax6	Paired box 6b. (346 aa)
	LOC109520091	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa)
	apoa4	Uncharacterized protein. (267 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1106 aa)
	dlx3	Distal-less homeobox 3b. (286 aa)
	LOC109515541	ABC transporter domain-containing protein. (191 aa)
	nkx6-1	NK6 homeobox 1. (353 aa)
	pcsk1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (767 aa)
	ENSHCOP00000010147	Endothelin 1. (182 aa)
	nf1	Neurofibromin 1b. (2754 aa)
	Rfx6	Regulatory factor X, 6. (616 aa)
	mnx1	Motor neuron and pancreas homeobox 1. (318 aa)
	LOC109523568	Retinal homeobox gene 3. (319 aa)
	SRF	Serum response factor. (344 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1203 aa)
	LOC109516855	T-cell acute lymphocytic leukemia 1. (387 aa)
	ENSHCOP00000007528	Achaete-scute family bHLH transcription factor 1b. (177 aa)
	LOC109516305	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1170 aa)
	ENSHCOP00000006849	G_PROTEIN_RECEP_F1_2 domain-containing protein. (156 aa)
	armc5	Armadillo repeat containing 5. (1150 aa)
	ENSHCOP00000005837	Uncharacterized protein. (206 aa)
	bsx	Brain-specific homeobox. (225 aa)
	LOC109513062	Uncharacterized protein. (430 aa)
	nkx6-2	NK6 homeobox 2. (295 aa)
	LOC109517690	Betaine-homocysteine methyltransferase. (411 aa)
	ednra	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (431 aa)
	LOC109523136	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (532 aa)
	LOC109523760	Uncharacterized protein. (271 aa)
	LOC109519656	Uncharacterized protein. (661 aa)
	LOC109527101	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (396 aa)
	LOC109517020	Homeobox domain-containing protein. (195 aa)
	GATA2	GATA binding protein 2. (434 aa)
	tbx1	T-box transcription factor 1. (513 aa)
	nkx2-5	NK2 homeobox 5. (314 aa)
	TBX2	T-box transcription factor 2. (675 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (321 aa)
	LOC109509914	Paired box 2a. (391 aa)
	LOC109519906	Paired box 5. (368 aa)
	LOC109528682	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	LOC109521925	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family. (179 aa)
	six6	SIX homeobox 6a. (260 aa)
	LOC109506899	ABC transmembrane type-1 domain-containing protein. (545 aa)
	PAX2	Paired box 2. (347 aa)
	ENSHCOP00000027596	Noggin; Belongs to the noggin family. (222 aa)
	LOC109514701	Regulatory factor X, 3 (influences HLA class II expression). (689 aa)
	ENSHCOP00000027094	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (520 aa)
	ENSHCOP00000027055	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (519 aa)
	Ascl1	Achaete-scute family bHLH transcription factor 1a. (195 aa)
	LOC109520718	Dickkopf WNT signaling pathway inhibitor 3b. (298 aa)
	LOC109530176	SIX homeobox 3b. (247 aa)
	LOC109522629	GATA binding protein 2a. (477 aa)
	wt1	WT1 transcription factor b. (426 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (808 aa)
	ENSHCOP00000023862	C2H2-type domain-containing protein. (553 aa)
	LOC109520788	Insulinoma-associated 1b. (371 aa)
	LOC109508381	SIX homeobox 7. (245 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ascl1	Nkx2-2	ENSHCOP00000027034	ENSHCOP00000012759	Achaete-scute family bHLH transcription factor 1a.	NK2 homeobox 2a.	0.412
Ascl1	gsx1	ENSHCOP00000027034	ENSHCOP00000017146	Achaete-scute family bHLH transcription factor 1a.	GS homeobox 1.	0.404
ENSHCOP00000006849	ENSHCOP00000010147	ENSHCOP00000006849	ENSHCOP00000010147	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Endothelin 1.	0.969
ENSHCOP00000007528	Nkx2-2	ENSHCOP00000007528	ENSHCOP00000012759	Achaete-scute family bHLH transcription factor 1b.	NK2 homeobox 2a.	0.439
ENSHCOP00000007528	gsx1	ENSHCOP00000007528	ENSHCOP00000017146	Achaete-scute family bHLH transcription factor 1b.	GS homeobox 1.	0.404
ENSHCOP00000010147	ENSHCOP00000006849	ENSHCOP00000010147	ENSHCOP00000006849	Endothelin 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.969
ENSHCOP00000010147	LOC109523037	ENSHCOP00000010147	ENSHCOP00000022017	Endothelin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.569
ENSHCOP00000010147	ednra	ENSHCOP00000010147	ENSHCOP00000004216	Endothelin 1.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.976
ENSHCOP00000010147	hand2	ENSHCOP00000010147	ENSHCOP00000017728	Endothelin 1.	Heart and neural crest derivatives expressed 2.	0.578
ENSHCOP00000010147	jag1	ENSHCOP00000010147	ENSHCOP00000008862	Endothelin 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.506
ENSHCOP00000018446	Nkx2-2	ENSHCOP00000018446	ENSHCOP00000012759	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	NK2 homeobox 2a.	0.463
ENSHCOP00000018446	Rfx6	ENSHCOP00000018446	ENSHCOP00000009376	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Regulatory factor X, 6.	0.460
ENSHCOP00000018446	pcsk1	ENSHCOP00000018446	ENSHCOP00000010369	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.584
ENSHCOP00000018446	pdx1	ENSHCOP00000018446	ENSHCOP00000014414	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Pancreatic and duodenal homeobox 1.	0.568
ENSHCOP00000021111	nkx2-5	ENSHCOP00000021111	ENSHCOP00000002574	T-box transcription factor 2a.	NK2 homeobox 5.	0.483
ENSHCOP00000023388	LOC109523037	ENSHCOP00000023388	ENSHCOP00000022017	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.620
ENSHCOP00000023388	Nkx2-2	ENSHCOP00000023388	ENSHCOP00000012759	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	NK2 homeobox 2a.	0.561
ENSHCOP00000023388	disp1	ENSHCOP00000023388	ENSHCOP00000021183	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Dispatched homolog 1 (Drosophila).	0.925
ENSHCOP00000023388	nkx6-1	ENSHCOP00000023388	ENSHCOP00000010497	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	NK6 homeobox 1.	0.434
ENSHCOP00000023388	smo	ENSHCOP00000023388	ENSHCOP00000024760	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.830