76 items (Hippocampus comes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
	ENSHCOP00000028168	SEFIR domain-containing protein. (116 aa)
	rnf168	RING-type domain-containing protein. (444 aa)
	aicda	Activation-induced cytidine deaminase. (189 aa)
	LOC109515231	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
	bax	BCL2 associated X, apoptosis regulator a. (255 aa)
	ENSHCOP00000026411	Uncharacterized protein. (408 aa)
	ENSHCOP00000025442	AGC-kinase C-terminal domain-containing protein. (68 aa)
	ENSHCOP00000024683	Uncharacterized protein. (182 aa)
	LOC109514850	E1A binding protein p300 b. (2669 aa)
	tnfsf13b	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (255 aa)
	ENSHCOP00000023902	SEFIR domain-containing protein. (110 aa)
	cmtm7	CKLF-like MARVEL transmembrane domain containing 7. (160 aa)
	lig4	DNA ligase. (910 aa)
	LOC109531236	MALT paracaspase 3. (638 aa)
	cd79a	CD79a molecule, immunoglobulin-associated alpha. (215 aa)
	rag1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1071 aa)
	rag2	Recombination activating gene 2. (534 aa)
	DCAF1	DDB1 and CUL4 associated factor 1. (1477 aa)
	dnajb9	DnaJ heat shock protein family (Hsp40) member B9b. (217 aa)
	ENSHCOP00000021185	Basic leucine zipper transcription factor, ATF-like. (119 aa)
	LOC109508060	Zgc:153993. (204 aa)
	card11	Caspase recruitment domain family, member 11. (1163 aa)
	Traf3ip2	SEFIR domain-containing protein. (114 aa)
	kiaa1841	Si:ch211-189k9.2. (626 aa)
	cebpg	CCAAT enhancer binding protein gamma. (246 aa)
	LOC109526980	Galectin. (134 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (578 aa)
	lef1	Lymphoid enhancer-binding factor 1. (380 aa)
	LOC109519631	Chemokine (C-C motif) receptor 6b; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	LOC109511934	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (227 aa)
	ENSHCOP00000016959	AGC-kinase C-terminal domain-containing protein. (50 aa)
	LOC109511124	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
	LOC109517348	Sp3b transcription factor. (632 aa)
	LOC109515431	Protein kinase C. (666 aa)
	prkca	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
	rabl3	RAB, member of RAS oncogene family-like 3. (219 aa)
	ENSHCOP00000015116	Uncharacterized protein. (622 aa)
	itfg2	Integrin alpha FG-GAP repeat containing 2. (418 aa)
	ENSHCOP00000014996	Uncharacterized protein. (113 aa)
	nkx2-3	NK2 homeobox 3. (338 aa)
	il7r	Fibronectin type-III domain-containing protein. (415 aa)
	phb	Prohibitin. (271 aa)
	ercc1	Excision repair cross-complementation group 1. (338 aa)
	LOC109511093	BHLH domain-containing protein. (391 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (946 aa)
	LOC109530914	DnaJ heat shock protein family (Hsp40) member B9a. (211 aa)
	exosc3	Exosome component 3. (246 aa)
	msh6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1375 aa)
	ENSHCOP00000009485	Uncharacterized protein. (719 aa)
	Atm	TAN domain-containing protein. (311 aa)
	ENSHCOP00000009180	Uncharacterized protein. (169 aa)
	LOC109513037	Ig-like domain-containing protein. (212 aa)
	txn	Thioredoxin; Belongs to the thioredoxin family. (110 aa)
	SP3	Sp3a transcription factor. (668 aa)
	ENSHCOP00000008016	Uncharacterized protein. (88 aa)
	LOC109512841	E1A binding protein p300 a. (2561 aa)
	LOC109511308	Galectin. (127 aa)
	ung	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (296 aa)
	gps2	G protein pathway suppressor 2. (339 aa)
	NKX2-3	NK2 homeobox 3. (273 aa)
	fnip1	Folliculin interacting protein 1. (1044 aa)
	LOC109513557	CD40 molecule, TNF receptor superfamily member 5. (309 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1232 aa)
	zbtb1	Zinc finger and BTB domain containing 1. (626 aa)
	ENSHCOP00000004818	DHR-1 domain-containing protein; Belongs to the DOCK family. (145 aa)
	ENSHCOP00000004798	PH domain-containing protein. (447 aa)
	LOC109527038	ATPase family AAA domain containing 5a. (1619 aa)
	skap2	Src kinase associated phosphoprotein 2. (320 aa)
	sash3	SAM and SH3 domain containing 3. (454 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (731 aa)
	ENSHCOP00000002506	BCL2 apoptosis regulator b. (225 aa)
	ENSHCOP00000002481	BCL2 apoptosis regulator b. (221 aa)
	ITM2A	Integral membrane protein 2A. (246 aa)
	ENSHCOP00000001568	Uncharacterized protein. (184 aa)
	ENSHCOP00000000810	MALT paracaspase 2. (513 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atm	ENSHCOP00000009180	ENSHCOP00000009193	ENSHCOP00000009180	TAN domain-containing protein.	Uncharacterized protein.	0.929
Atm	ENSHCOP00000026411	ENSHCOP00000009193	ENSHCOP00000026411	TAN domain-containing protein.	Uncharacterized protein.	0.506
Atm	LOC109512841	ENSHCOP00000009193	ENSHCOP00000007909	TAN domain-containing protein.	E1A binding protein p300 a.	0.407
Atm	LOC109514850	ENSHCOP00000009193	ENSHCOP00000024673	TAN domain-containing protein.	E1A binding protein p300 b.	0.407
Atm	LOC109527038	ENSHCOP00000009193	ENSHCOP00000004580	TAN domain-containing protein.	ATPase family AAA domain containing 5a.	0.506
Atm	ercc1	ENSHCOP00000009193	ENSHCOP00000014052	TAN domain-containing protein.	Excision repair cross-complementation group 1.	0.616
Atm	lig4	ENSHCOP00000009193	ENSHCOP00000023467	TAN domain-containing protein.	DNA ligase.	0.604
Atm	mlh1	ENSHCOP00000009193	ENSHCOP00000002960	TAN domain-containing protein.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.846
Atm	msh2	ENSHCOP00000009193	ENSHCOP00000013100	TAN domain-containing protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.769
Atm	msh6	ENSHCOP00000009193	ENSHCOP00000010111	TAN domain-containing protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.765
Atm	rnf168	ENSHCOP00000009193	ENSHCOP00000027484	TAN domain-containing protein.	RING-type domain-containing protein.	0.816
Atm	rnf8	ENSHCOP00000009193	ENSHCOP00000019737	TAN domain-containing protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.820
DCAF1	ENSHCOP00000008016	ENSHCOP00000022261	ENSHCOP00000008016	DDB1 and CUL4 associated factor 1.	Uncharacterized protein.	0.871
DCAF1	ung	ENSHCOP00000022261	ENSHCOP00000007299	DDB1 and CUL4 associated factor 1.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.871
ENSHCOP00000000810	card11	ENSHCOP00000000810	ENSHCOP00000020756	MALT paracaspase 2.	Caspase recruitment domain family, member 11.	0.916
ENSHCOP00000002481	LOC109508060	ENSHCOP00000002481	ENSHCOP00000020948	BCL2 apoptosis regulator b.	Zgc:153993.	0.771
ENSHCOP00000002481	bax	ENSHCOP00000002481	ENSHCOP00000026539	BCL2 apoptosis regulator b.	BCL2 associated X, apoptosis regulator a.	0.935
ENSHCOP00000002506	LOC109508060	ENSHCOP00000002506	ENSHCOP00000020948	BCL2 apoptosis regulator b.	Zgc:153993.	0.976
ENSHCOP00000002506	bax	ENSHCOP00000002506	ENSHCOP00000026539	BCL2 apoptosis regulator b.	BCL2 associated X, apoptosis regulator a.	0.993
ENSHCOP00000004798	ENSHCOP00000004818	ENSHCOP00000004798	ENSHCOP00000004818	PH domain-containing protein.	DHR-1 domain-containing protein; Belongs to the DOCK family.	0.921