(83 nodes) Positive regulation of I-kappaB kinase/NF-kappaB signaling network (Hippocampus comes)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109519328	Mitogen-activated protein kinase kinase kinase 14a. (780 aa)
	JMJD8	Jumonji domain containing 8. (262 aa)
	tmem101	Transmembrane protein 101. (255 aa)
	LOC109514643	Uncharacterized protein. (86 aa)
	LOC109532260	Tyrosine-protein kinase. (1170 aa)
	LOC109520533	Uncharacterized protein; Belongs to the peptidase C14A family. (492 aa)
	ENSHCOP00000002109	Uncharacterized protein. (765 aa)
	alpk1	Alpha-type protein kinase domain-containing protein. (837 aa)
	dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36. (966 aa)
	tnfsf11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (266 aa)
	irak4	Interleukin-1 receptor-associated kinase 4. (468 aa)
	LURAP1L	Leucine rich adaptor protein 1 like. (195 aa)
	tnip2	CCHC NOA-type domain-containing protein. (458 aa)
	LOC109525796	Inhibitor of nuclear factor kappa B kinase subunit beta. (674 aa)
	mul1	Mitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
	ENSHCOP00000006379	Protein kinase domain-containing protein. (137 aa)
	LOC109522194	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (708 aa)
	LOC109513557	CD40 molecule, TNF receptor superfamily member 5. (309 aa)
	LOC109520935	Innate immunity activator a. (533 aa)
	ENSHCOP00000006922	SCY domain-containing protein. (117 aa)
	ENSHCOP00000007241	Uncharacterized protein. (57 aa)
	ajuba	Ajuba LIM protein. (640 aa)
	htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (470 aa)
	LOC109524061	Uncharacterized protein. (935 aa)
	ddx1	DEAD (Asp-Glu-Ala-Asp) box helicase 1. (771 aa)
	C18orf32	Chromosome 18 open reading frame 32. (82 aa)
	Lpar1	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (318 aa)
	ENSHCOP00000009932	Tripartite motif containing 32. (638 aa)
	rbck1	RanBP-type and C3HC4-type zinc finger containing 1. (504 aa)
	f2r	Coagulation factor II (thrombin) receptor; Belongs to the G-protein coupled receptor 1 family. (430 aa)
	LOC109507041	DEAH (Asp-Glu-Ala-His) box helicase 15. (707 aa)
	LOC109517305	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (294 aa)
	cth	Cystathionase (cystathionine gamma-lyase), like. (411 aa)
	cflar	Uncharacterized protein; Belongs to the peptidase C14A family. (480 aa)
	LOC109515323	Tumor necrosis factor receptor superfamily, member 1a. (383 aa)
	sharpin	SHANK-associated RH domain interacting protein. (490 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (568 aa)
	LOC109514691	Tyrosine-protein kinase. (1079 aa)
	LOC109512681	RING-type domain-containing protein. (553 aa)
	tab3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (610 aa)
	prkca	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
	LOC109515431	Protein kinase C. (666 aa)
	terf2ip	BRCT domain-containing protein. (671 aa)
	ENSHCOP00000016175	G protein-coupled receptor, class C, group 5, member Bb. (398 aa)
	trim62	Tripartite motif containing 62, tandem duplicate 1. (475 aa)
	LOC109511124	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
	ENSHCOP00000016959	AGC-kinase C-terminal domain-containing protein. (50 aa)
	nod2	Nucleotide-binding oligomerization domain containing 2. (949 aa)
	tradd	Tnfrsf1a-associated via death domain. (288 aa)
	LOC109518998	Leucine rich adaptor protein 1. (285 aa)
	ENSHCOP00000020570	TANK-binding kinase 1. (341 aa)
	LOC109521023	Tumor necrosis factor b (TNF superfamily, member 2); Belongs to the tumor necrosis factor family. (266 aa)
	Traf3ip2	SEFIR domain-containing protein. (114 aa)
	card11	Caspase recruitment domain family, member 11. (1163 aa)
	tab2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (755 aa)
	FADD	Fas associated via death domain. (188 aa)
	edar	Ectodysplasin A receptor. (499 aa)
	LOC109518471	Uncharacterized protein. (767 aa)
	tifa	Si:ch211-15b10.6. (190 aa)
	LOC109529262	Zgc:171965. (442 aa)
	LOC109511977	Sharpin and rbck1 related. (679 aa)
	ENSHCOP00000023902	SEFIR domain-containing protein. (110 aa)
	mtdh	Uncharacterized protein. (544 aa)
	LOC109507480	Bromodomain containing 4. (1553 aa)
	ddx21	DEAD (Asp-Glu-Ala-Asp) box helicase 21. (780 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (674 aa)
	LOC109516174	Tripartite motif containing 8b. (583 aa)
	ENSHCOP00000025442	AGC-kinase C-terminal domain-containing protein. (68 aa)
	LOC109516272	Component of inhibitor of nuclear factor kappa B kinase complex. (739 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	ENSHCOP00000026762	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (190 aa)
	LOC109518541	ADP-ribosylation factor 2b. (798 aa)
	LOC109515231	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
	myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (287 aa)
	DHX15	DEAH-box helicase 15. (598 aa)
	gprc5b	G protein-coupled receptor, class C, group 5, member Ba. (406 aa)
	ENSHCOP00000027112	OB_NTP_bind domain-containing protein. (230 aa)
	LOC109529256	Protein kinase domain-containing protein. (503 aa)
	LOC109522605	Innate immunity activator b. (579 aa)
	LOC109527991	Uncharacterized protein. (485 aa)
	LOC109509327	Uncharacterized protein. (154 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (585 aa)
	ENSHCOP00000028168	SEFIR domain-containing protein. (116 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHX15	ENSHCOP00000027112	ENSHCOP00000027096	ENSHCOP00000027112	DEAH-box helicase 15.	OB_NTP_bind domain-containing protein.	0.919
DHX15	LOC109507041	ENSHCOP00000027096	ENSHCOP00000011901	DEAH-box helicase 15.	DEAH (Asp-Glu-Ala-His) box helicase 15.	0.901
DHX15	ddx1	ENSHCOP00000027096	ENSHCOP00000009098	DEAH-box helicase 15.	DEAD (Asp-Glu-Ala-Asp) box helicase 1.	0.587
DHX15	ddx21	ENSHCOP00000027096	ENSHCOP00000024838	DEAH-box helicase 15.	DEAD (Asp-Glu-Ala-Asp) box helicase 21.	0.641
ENSHCOP00000006379	LOC109515323	ENSHCOP00000006379	ENSHCOP00000014336	Protein kinase domain-containing protein.	Tumor necrosis factor receptor superfamily, member 1a.	0.794
ENSHCOP00000006379	LOC109518471	ENSHCOP00000006379	ENSHCOP00000021443	Protein kinase domain-containing protein.	Uncharacterized protein.	0.732
ENSHCOP00000006379	LOC109524061	ENSHCOP00000006379	ENSHCOP00000009013	Protein kinase domain-containing protein.	Uncharacterized protein.	0.732
ENSHCOP00000006379	myd88	ENSHCOP00000006379	ENSHCOP00000027086	Protein kinase domain-containing protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.495
ENSHCOP00000006379	tab2	ENSHCOP00000006379	ENSHCOP00000020857	Protein kinase domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.543
ENSHCOP00000006379	tab3	ENSHCOP00000006379	ENSHCOP00000015683	Protein kinase domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.543
ENSHCOP00000006379	tradd	ENSHCOP00000006379	ENSHCOP00000019212	Protein kinase domain-containing protein.	Tnfrsf1a-associated via death domain.	0.611
ENSHCOP00000007241	myd88	ENSHCOP00000007241	ENSHCOP00000027086	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.970
ENSHCOP00000007241	tab2	ENSHCOP00000007241	ENSHCOP00000020857	Uncharacterized protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.541
ENSHCOP00000007241	tab3	ENSHCOP00000007241	ENSHCOP00000015683	Uncharacterized protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.541
ENSHCOP00000009932	LOC109512681	ENSHCOP00000009932	ENSHCOP00000015676	Tripartite motif containing 32.	RING-type domain-containing protein.	0.407
ENSHCOP00000009932	LOC109516174	ENSHCOP00000009932	ENSHCOP00000025435	Tripartite motif containing 32.	Tripartite motif containing 8b.	0.407
ENSHCOP00000009932	trim62	ENSHCOP00000009932	ENSHCOP00000016626	Tripartite motif containing 32.	Tripartite motif containing 62, tandem duplicate 1.	0.417
ENSHCOP00000016959	card11	ENSHCOP00000016959	ENSHCOP00000020756	AGC-kinase C-terminal domain-containing protein.	Caspase recruitment domain family, member 11.	0.534
ENSHCOP00000020570	LOC109515323	ENSHCOP00000020570	ENSHCOP00000014336	TANK-binding kinase 1.	Tumor necrosis factor receptor superfamily, member 1a.	0.794
ENSHCOP00000020570	LOC109518471	ENSHCOP00000020570	ENSHCOP00000021443	TANK-binding kinase 1.	Uncharacterized protein.	0.732