(78 nodes) Positive regulation of DNA repair network (Hippocampus comes)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	arid2	AT rich interactive domain 2 (ARID, RFX-like). (1600 aa)
	sirt6	Sirtuin 6. (347 aa)
	tmem161a	Transmembrane protein 161A. (487 aa)
	LOC109513825	Major facilitator superfamily domain containing 11. (441 aa)
	trrap	Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. (3534 aa)
	ENSHCOP00000001726	Uncharacterized protein. (267 aa)
	bcl7a	BAF chromatin remodeling complex subunit BCL7A. (190 aa)
	ENSHCOP00000003038	Uncharacterized protein. (850 aa)
	LOC109524269	Bromodomain containing 8. (761 aa)
	LOC109523155	Sirtuin 1. (657 aa)
	LOC109522167	Poly [ADP-ribose] polymerase. (524 aa)
	mrgbp	MRG/MORF4L binding protein. (211 aa)
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (612 aa)
	vps72	Vacuolar protein sorting 72 homolog a. (371 aa)
	babam1	BRISC and BRCA1 A complex member 1. (373 aa)
	rad51ap1	RAD51_interact domain-containing protein. (275 aa)
	LOC109527740	Lysine methyltransferase 5C. (429 aa)
	LOC109509139	Uncharacterized protein. (138 aa)
	LOC109521469	SET domain and mariner transposase fusion gene. (295 aa)
	ccdc117	Si:ch211-102c2.7. (273 aa)
	ENSHCOP00000008597	HTH_Tnp_Tc3_2 domain-containing protein. (219 aa)
	ENSHCOP00000008732	Pogo transposable element derived with ZNF domain b. (1733 aa)
	prkdc	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3890 aa)
	tigar	TP53 induced glycolysis regulatory phosphatase a. (263 aa)
	dhx9	DEAH (Asp-Glu-Ala-His) box helicase 9. (1267 aa)
	ENSHCOP00000010439	Spire-type actin nucleation factor 1a. (781 aa)
	ENSHCOP00000010540	Helicase, POLQ like. (557 aa)
	LOC109513483	Uncharacterized protein. (223 aa)
	ENSHCOP00000011276	KIND domain-containing protein. (143 aa)
	actr2	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
	yeats4	YEATS domain containing 4. (226 aa)
	fam168a	Family with sequence similarity 168 member A. (226 aa)
	MGMT	O-6-methylguanine-DNA methyltransferase. (189 aa)
	rif1	Replication timing regulatory factor 1. (2634 aa)
	dtx3	Zgc:66440. (358 aa)
	ercc8	Excision repair cross-complementation group 8. (384 aa)
	ENSHCOP00000014695	FAM35_C domain-containing protein. (255 aa)
	Spidr	DUF4503 domain-containing protein. (454 aa)
	timeless	Timeless circadian clock. (1222 aa)
	fh	Fumarate hydratase. (499 aa)
	Brd8	Uncharacterized protein. (79 aa)
	brca1	Uncharacterized protein. (1141 aa)
	tfpt	TCF3 (E2A) fusion partner. (198 aa)
	pias4	Protein inhibitor of activated STAT, 4a. (488 aa)
	ino80	INO80 complex ATPase subunit. (1543 aa)
	fancb	FA complementation group B. (797 aa)
	ENSHCOP00000019285	Deacetylase sirtuin-type domain-containing protein. (166 aa)
	ENSHCOP00000019306	Sirtuin 1. (369 aa)
	LOC109522412	Poly [ADP-ribose] polymerase. (528 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (578 aa)
	ino80d	INO80 complex subunit Da. (979 aa)
	kmt5b	Lysine methyltransferase 5B. (862 aa)
	mfsd11	Uncharacterized protein. (405 aa)
	cebpg	CCAAT enhancer binding protein gamma. (246 aa)
	uchl5	Ubiquitin carboxyl-terminal hydrolase. (329 aa)
	LOC109518982	Enhancer of polycomb homolog. (835 aa)
	mms19	MMS19 homolog, cytosolic iron-sulfur assembly component. (929 aa)
	wrap53	WD repeat containing, antisense to TP53. (533 aa)
	Brcc3	BRCA1/BRCA2-containing complex, subunit 3. (284 aa)
	babam2	BRISC and BRCA1 A complex member 2. (366 aa)
	parp1	Poly [ADP-ribose] polymerase. (1020 aa)
	LOC109529502	Enhancer of polycomb homolog. (775 aa)
	LOC109508375	Zgc:101810; Belongs to the actin family. (394 aa)
	ino80e	INO80 complex subunit E. (236 aa)
	eya3	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (562 aa)
	abraxas1	Abraxas 1, BRCA1 A complex subunit. (351 aa)
	ENSHCOP00000024593	Uncharacterized protein. (129 aa)
	pnkp	Polynucleotide kinase 3'-phosphatase. (609 aa)
	wdr48	WD repeat domain 48b. (677 aa)
	foxm1	Forkhead box M1. (642 aa)
	actl6a	Actin-like 6A; Belongs to the actin family. (429 aa)
	rnf168	RING-type domain-containing protein. (444 aa)
	Slf1	Uncharacterized protein. (142 aa)
	mcrs1	Microspherule protein 1. (464 aa)
	dmap1	DNA methyltransferase 1 associated protein 1. (480 aa)
	hdgfl2	HDGF like 2. (621 aa)
	nfrkb	Nuclear factor related to kappaB binding protein. (1123 aa)
	ercc6	Excision repair cross-complementation group 6. (1377 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brcc3	abraxas1	ENSHCOP00000022578	ENSHCOP00000024091	BRCA1/BRCA2-containing complex, subunit 3.	Abraxas 1, BRCA1 A complex subunit.	0.491
Brcc3	babam1	ENSHCOP00000022578	ENSHCOP00000005805	BRCA1/BRCA2-containing complex, subunit 3.	BRISC and BRCA1 A complex member 1.	0.999
Brcc3	babam2	ENSHCOP00000022578	ENSHCOP00000023074	BRCA1/BRCA2-containing complex, subunit 3.	BRISC and BRCA1 A complex member 2.	0.999
Brcc3	brca1	ENSHCOP00000022578	ENSHCOP00000016663	BRCA1/BRCA2-containing complex, subunit 3.	Uncharacterized protein.	0.958
Brcc3	ercc8	ENSHCOP00000022578	ENSHCOP00000014470	BRCA1/BRCA2-containing complex, subunit 3.	Excision repair cross-complementation group 8.	0.501
Brcc3	pias4	ENSHCOP00000022578	ENSHCOP00000017487	BRCA1/BRCA2-containing complex, subunit 3.	Protein inhibitor of activated STAT, 4a.	0.658
Brcc3	rif1	ENSHCOP00000022578	ENSHCOP00000012872	BRCA1/BRCA2-containing complex, subunit 3.	Replication timing regulatory factor 1.	0.581
Brcc3	rnf168	ENSHCOP00000022578	ENSHCOP00000027484	BRCA1/BRCA2-containing complex, subunit 3.	RING-type domain-containing protein.	0.726
Brcc3	rnf8	ENSHCOP00000022578	ENSHCOP00000019737	BRCA1/BRCA2-containing complex, subunit 3.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.699
Brcc3	uchl5	ENSHCOP00000022578	ENSHCOP00000021396	BRCA1/BRCA2-containing complex, subunit 3.	Ubiquitin carboxyl-terminal hydrolase.	0.816
Brcc3	xrcc1	ENSHCOP00000022578	ENSHCOP00000004092	BRCA1/BRCA2-containing complex, subunit 3.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.549
Brd8	ENSHCOP00000001726	ENSHCOP00000016260	ENSHCOP00000001726	Uncharacterized protein.	Uncharacterized protein.	0.755
Brd8	LOC109509139	ENSHCOP00000016260	ENSHCOP00000007119	Uncharacterized protein.	Uncharacterized protein.	0.761
Brd8	LOC109518982	ENSHCOP00000016260	ENSHCOP00000021678	Uncharacterized protein.	Enhancer of polycomb homolog.	0.736
Brd8	LOC109529502	ENSHCOP00000016260	ENSHCOP00000023253	Uncharacterized protein.	Enhancer of polycomb homolog.	0.736
Brd8	actl6a	ENSHCOP00000016260	ENSHCOP00000027255	Uncharacterized protein.	Actin-like 6A; Belongs to the actin family.	0.670
Brd8	dmap1	ENSHCOP00000016260	ENSHCOP00000027781	Uncharacterized protein.	DNA methyltransferase 1 associated protein 1.	0.870
Brd8	ino80	ENSHCOP00000016260	ENSHCOP00000018117	Uncharacterized protein.	INO80 complex ATPase subunit.	0.508
Brd8	mcrs1	ENSHCOP00000016260	ENSHCOP00000027675	Uncharacterized protein.	Microspherule protein 1.	0.559
Brd8	mrgbp	ENSHCOP00000016260	ENSHCOP00000003995	Uncharacterized protein.	MRG/MORF4L binding protein.	0.892