(29 nodes) Negative regulation of innate immune response network (Hippocampus comes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109527673	GRANULINS domain-containing protein. (188 aa)
	ENSHCOP00000007763	Uncharacterized protein. (517 aa)
	LOC109510435	TRAF-type zinc finger domain containing 1. (543 aa)
	FAM3A	Family with sequence similarity 3 member A. (230 aa)
	lyar	Ly1 antibody reactive homolog (mouse). (305 aa)
	Ythdf3	YTH N(6)-methyladenosine RNA binding protein 3. (569 aa)
	ythdf2	YTH N(6)-methyladenosine RNA binding protein 2. (637 aa)
	ttll12	Tubulin tyrosine ligase-like family, member 12. (628 aa)
	samhd1	SAM domain and HD domain 1. (620 aa)
	pias4	Protein inhibitor of activated STAT, 4a. (488 aa)
	dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58. (673 aa)
	igf2	Insulin-like growth factor 2b. (216 aa)
	ENSHCOP00000026803	Granulin b. (551 aa)
	atg12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (177 aa)
	LOC109508512	Si:dkey-175m17.7. (863 aa)
	ENSHCOP00000028091	Uncharacterized protein. (514 aa)
	dusp10	Dual specificity phosphatase 10. (472 aa)
	mettl3	Methyltransferase like 3; Belongs to the MT-A70-like family. (575 aa)
	gfer	Sulfhydryl oxidase. (190 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (753 aa)
	cactin	Cactin. (846 aa)
	ENSHCOP00000022841	DC_STAMP domain-containing protein. (227 aa)
	nlrx1	NLR family member X1. (968 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (252 aa)
	OTOP1	Otopetrin 1. (592 aa)
	adar	Adenosine deaminase RNA specific. (1278 aa)
	mul1	Mitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
	ENSHCOP00000007014	Interleukin-1 receptor-associated kinase 3. (331 aa)
	acod1	Aconitate decarboxylase 1. (506 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ythdf3	mettl3	ENSHCOP00000012237	ENSHCOP00000001822	YTH N(6)-methyladenosine RNA binding protein 3.	Methyltransferase like 3; Belongs to the MT-A70-like family.	0.581
adar	dhx58	ENSHCOP00000005787	ENSHCOP00000019409	Adenosine deaminase RNA specific.	DEXH (Asp-Glu-X-His) box polypeptide 58.	0.461
adar	samhd1	ENSHCOP00000005787	ENSHCOP00000016785	Adenosine deaminase RNA specific.	SAM domain and HD domain 1.	0.478
atg12	atg5	ENSHCOP00000027384	ENSHCOP00000024252	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
atg12	dhx58	ENSHCOP00000027384	ENSHCOP00000019409	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DEXH (Asp-Glu-X-His) box polypeptide 58.	0.455
atg12	nlrx1	ENSHCOP00000027384	ENSHCOP00000023729	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family member X1.	0.570
atg5	atg12	ENSHCOP00000024252	ENSHCOP00000027384	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
atg5	dhx58	ENSHCOP00000024252	ENSHCOP00000019409	Autophagy protein 5; Involved in autophagic vesicle formation.	DEXH (Asp-Glu-X-His) box polypeptide 58.	0.449
atg5	nlrx1	ENSHCOP00000024252	ENSHCOP00000023729	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family member X1.	0.591
dhx58	adar	ENSHCOP00000019409	ENSHCOP00000005787	DEXH (Asp-Glu-X-His) box polypeptide 58.	Adenosine deaminase RNA specific.	0.461
dhx58	atg12	ENSHCOP00000019409	ENSHCOP00000027384	DEXH (Asp-Glu-X-His) box polypeptide 58.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.455
dhx58	atg5	ENSHCOP00000019409	ENSHCOP00000024252	DEXH (Asp-Glu-X-His) box polypeptide 58.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.449
mettl3	Ythdf3	ENSHCOP00000001822	ENSHCOP00000012237	Methyltransferase like 3; Belongs to the MT-A70-like family.	YTH N(6)-methyladenosine RNA binding protein 3.	0.581
mettl3	ythdf2	ENSHCOP00000001822	ENSHCOP00000012734	Methyltransferase like 3; Belongs to the MT-A70-like family.	YTH N(6)-methyladenosine RNA binding protein 2.	0.578
nlrx1	atg12	ENSHCOP00000023729	ENSHCOP00000027384	NLR family member X1.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.570
nlrx1	atg5	ENSHCOP00000023729	ENSHCOP00000024252	NLR family member X1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.591
samhd1	adar	ENSHCOP00000016785	ENSHCOP00000005787	SAM domain and HD domain 1.	Adenosine deaminase RNA specific.	0.478
ythdf2	mettl3	ENSHCOP00000012734	ENSHCOP00000001822	YTH N(6)-methyladenosine RNA binding protein 2.	Methyltransferase like 3; Belongs to the MT-A70-like family.	0.578