(87 nodes) Digestive tract development network (Hippocampus comes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSHCOP00000021867	Selenoprotein H. (148 aa)
	Msc	Musculin (activated B-cell factor-1). (120 aa)
	agr2	Anterior gradient 2. (167 aa)
	rb1	Retinoblastoma 1. (903 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (369 aa)
	invs	Inversin. (669 aa)
	LOC109523822	PR domain containing 1b, with ZNF domain. (618 aa)
	LOC109514581	T-box transcription factor Ta. (429 aa)
	LOC109520617	Endothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (460 aa)
	myocd	SAP domain-containing protein. (777 aa)
	ENSHCOP00000018004	Fork-head domain-containing protein. (320 aa)
	hand2	Heart and neural crest derivatives expressed 2. (203 aa)
	ezh2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (701 aa)
	LOC109511954	Transforming growth factor beta; Belongs to the TGF-beta family. (423 aa)
	pkd1	Polycystic kidney disease 1a. (4575 aa)
	foxa3	Forkhead box A3. (434 aa)
	LOC109514706	Nipped-B protein. (2815 aa)
	hnf1b	HNF1 homeobox Ba. (629 aa)
	klf5	Progesterone immunomodulatory binding factor 1. (438 aa)
	ENSHCOP00000014542	Uncharacterized protein. (114 aa)
	nkx2-3	NK2 homeobox 3. (338 aa)
	hhex	Homeobox domain-containing protein. (320 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (250 aa)
	myf5	Myogenic factor. (220 aa)
	ENSHCOP00000014391	NK2 transcription factor related 7. (150 aa)
	mib1	Mindbomb E3 ubiquitin protein ligase 1. (995 aa)
	LOC109521258	GATA binding protein 6. (363 aa)
	rnpc3	RNA-binding region (RNP1, RRM) containing 3. (504 aa)
	ENSHCOP00000013434	C2H2-type domain-containing protein. (124 aa)
	chd8	Chromodomain helicase DNA binding protein 8. (2051 aa)
	mb	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (147 aa)
	ENSHCOP00000012552	Uncharacterized protein. (340 aa)
	LOC109525531	Uncharacterized protein. (324 aa)
	ENSHCOP00000011367	PLAT domain-containing protein. (274 aa)
	tp63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (544 aa)
	LOC109508596	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (771 aa)
	VANGL2	Vang-like protein. (527 aa)
	mixl1	Mix paired-like homeobox. (279 aa)
	LOC109514168	Nipped-B protein. (2434 aa)
	ENSHCOP00000009146	Abelson helper integration site 1. (838 aa)
	gata4	GATA binding protein 4. (409 aa)
	MYOD1	Myogenic factor. (279 aa)
	LOC109518000	Kruppel-like factor 5 like. (418 aa)
	pdgfc	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (326 aa)
	foxf2	Forkhead box F2b. (386 aa)
	NKX2-3	NK2 homeobox 3. (273 aa)
	Ascl1	Achaete-scute family bHLH transcription factor 1a. (195 aa)
	LOC109514688	nipped-B-like protein B. (104 aa)
	LOC109525772	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (571 aa)
	IKZF5	IKAROS family zinc finger 5. (389 aa)
	tp73	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (571 aa)
	med24	Mediator complex subunit 24. (718 aa)
	sav1	Salvador family WW domain containing protein 1. (403 aa)
	LOC109520703	Forkhead box L1. (319 aa)
	pkdcc	Protein kinase domain containing, cytoplasmic b. (505 aa)
	il6st	Uncharacterized protein. (895 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (808 aa)
	ENSHCOP00000024667	Uncharacterized protein. (104 aa)
	ENSHCOP00000024644	annotation not available (274 aa)
	LOC109512260	PR domain containing 1a, with ZNF domain. (745 aa)
	wdr55	WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis. Belongs to the WD repeat WDR55 family. (374 aa)
	ruvbl2	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (464 aa)
	gpr22	G protein-coupled receptor 22b. (417 aa)
	ENSHCOP00000023388	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (407 aa)
	yap1	Yes-associated protein 1. (434 aa)
	clmp	Uncharacterized protein. (378 aa)
	vps52	VPS52 subunit of GARP complex. (750 aa)
	pitx2	Homeobox protein. (308 aa)
	tcf21	Transcription factor 21. (159 aa)
	nkx3-2	NK3 homeobox 2. (244 aa)
	sfrp2	Secreted frizzled-related protein 2. (299 aa)
	tbx20	T-box transcription factor 20. (444 aa)
	LOC109519656	Uncharacterized protein. (661 aa)
	LOC109529895	Uncharacterized protein; Belongs to the potassium channel family. (645 aa)
	gata5	GATA binding protein 5. (393 aa)
	tbx1	T-box transcription factor 1. (513 aa)
	fgfr2	Fibroblast growth factor receptor. (683 aa)
	ENSHCOP00000002506	BCL2 apoptosis regulator b. (225 aa)
	ENSHCOP00000002481	BCL2 apoptosis regulator b. (221 aa)
	LOC109524363	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (412 aa)
	prkci	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (588 aa)
	wtip	WT1 interacting protein. (633 aa)
	LOC109521915	Cordon-bleu WH2 repeat protein. (1443 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	LOC109516796	Uncharacterized protein. (761 aa)
	utp25	UTP25 small subunit processor component. (753 aa)
	ENSHCOP00000021915	G_PROTEIN_RECEP_F1_2 domain-containing protein. (144 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHCOP00000009146	invs	ENSHCOP00000009146	ENSHCOP00000019162	Abelson helper integration site 1.	Inversin.	0.640
ENSHCOP00000014542	med24	ENSHCOP00000014542	ENSHCOP00000026710	Uncharacterized protein.	Mediator complex subunit 24.	0.954
ENSHCOP00000021867	LOC109508596	ENSHCOP00000021867	ENSHCOP00000011065	Selenoprotein H.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.636
ENSHCOP00000021867	chd8	ENSHCOP00000021867	ENSHCOP00000013395	Selenoprotein H.	Chromodomain helicase DNA binding protein 8.	0.406
ENSHCOP00000021867	ezh2	ENSHCOP00000021867	ENSHCOP00000017458	Selenoprotein H.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.636
ENSHCOP00000021867	ruvbl2	ENSHCOP00000021867	ENSHCOP00000023479	Selenoprotein H.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.674
ENSHCOP00000021915	LOC109524363	ENSHCOP00000021915	ENSHCOP00000002184	G_PROTEIN_RECEP_F1_2 domain-containing protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.900
ENSHCOP00000023388	LOC109514581	ENSHCOP00000023388	ENSHCOP00000018427	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	T-box transcription factor Ta.	0.430
ENSHCOP00000023388	pitx2	ENSHCOP00000023388	ENSHCOP00000006816	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Homeobox protein.	0.407
ENSHCOP00000023388	smo	ENSHCOP00000023388	ENSHCOP00000024760	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.830
ENSHCOP00000023388	vps52	ENSHCOP00000023388	ENSHCOP00000006844	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	VPS52 subunit of GARP complex.	0.695
ENSHCOP00000024667	LOC109514168	ENSHCOP00000024667	ENSHCOP00000009284	Uncharacterized protein.	Nipped-B protein.	0.900
LOC109508596	ENSHCOP00000021867	ENSHCOP00000011065	ENSHCOP00000021867	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Selenoprotein H.	0.636
LOC109511954	tgfb2	ENSHCOP00000016943	ENSHCOP00000000057	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.901
LOC109514168	ENSHCOP00000024667	ENSHCOP00000009284	ENSHCOP00000024667	Nipped-B protein.	Uncharacterized protein.	0.900
LOC109514168	LOC109514688	ENSHCOP00000009284	ENSHCOP00000027266	Nipped-B protein.	nipped-B-like protein B.	0.900
LOC109514581	ENSHCOP00000023388	ENSHCOP00000018427	ENSHCOP00000023388	T-box transcription factor Ta.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.430
LOC109514581	LOC109521258	ENSHCOP00000018427	ENSHCOP00000014112	T-box transcription factor Ta.	GATA binding protein 6.	0.408
LOC109514581	gata4	ENSHCOP00000018427	ENSHCOP00000008932	T-box transcription factor Ta.	GATA binding protein 4.	0.487
LOC109514581	mixl1	ENSHCOP00000018427	ENSHCOP00000009286	T-box transcription factor Ta.	Mix paired-like homeobox.	0.640