(50 nodes) Oligodendrocyte differentiation network (Hippocampus comes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSHCOP00000022196	Uncharacterized protein. (655 aa)
	LOC109528721	Tetraspanin. (211 aa)
	sox9	SRY-box transcription factor 9a. (492 aa)
	LOC109516667	Zgc:109889. (437 aa)
	LOC109517741	SRY-box transcription factor 9b. (488 aa)
	cntn2	Contactin 2. (1042 aa)
	eif2b1	Eukaryotic translation initiation factor 2B, subunit 1 alpha; Belongs to the eIF-2B alpha/beta/delta subunits family. (302 aa)
	LOC109515913	Proteolipid protein 1a. (285 aa)
	cdk5	Cyclin-dependent kinase 5. (258 aa)
	dusp10	Dual specificity phosphatase 10. (472 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
	nkx6-2	NK6 homeobox 2. (295 aa)
	eif2b4	Eukaryotic translation initiation factor 2B, subunit 4 delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (525 aa)
	ihh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
	prdm8	PR domain containing 8b. (308 aa)
	aspa	Aspartoacylase. (287 aa)
	nf1	Neurofibromin 1b. (2754 aa)
	nkx6-1	NK6 homeobox 1. (353 aa)
	LOC109515541	ABC transporter domain-containing protein. (191 aa)
	NCSTN	Nicastrin. (701 aa)
	gpr17	G protein-coupled receptor 17. (339 aa)
	TPPP	Tubulin polymerization promoting protein. (217 aa)
	ercc2	Excision repair cross-complementation group 2. (591 aa)
	fa2h	Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (381 aa)
	eif2b5	Eukaryotic translation initiation factor 2B, subunit 5 epsilon. (703 aa)
	Nkx2-2	NK2 homeobox 2a. (255 aa)
	vtn	Vitronectin a. (525 aa)
	LOC109510758	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	LOC109523373	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	LOC109511486	Aspartoacylase (aminocyclase) 3, tandem duplicate 2. (309 aa)
	LOC109517921	WH2 domain-containing protein. (459 aa)
	LOC109507770	Tetraspanin 2a; Belongs to the tetraspanin (TM4SF) family. (203 aa)
	leo1	LEO1 homolog, Paf1/RNA polymerase II complex component. (657 aa)
	cdkn2c	Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (172 aa)
	CNP	2',3'-cyclic nucleotide 3' phosphodiesterase. (590 aa)
	LOC109520289	Uncharacterized protein. (294 aa)
	LOC109512366	Proteolipid protein 1b. (263 aa)
	sox10	SRY-box transcription factor 10. (498 aa)
	eif2b2	Eukaryotic translation initiation factor 2B, subunit 2 beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (355 aa)
	LOC109532034	Vitronectin b. (531 aa)
	LOC109523037	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	eif2b3	Eukaryotic translation initiation factor 2B, subunit 3 gamma. (489 aa)
	ENSHCOP00000022759	Alpha-carbonic anhydrase domain-containing protein. (308 aa)
	ENSHCOP00000023388	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (407 aa)
	LOC109511477	HMG box domain-containing protein. (498 aa)
	wasf3	WASP family member 3b. (490 aa)
	LOC109516679	Zinc finger protein 16 like. (444 aa)
	Znf488	PR domain containing 8. (467 aa)
	LOC109506899	ABC transmembrane type-1 domain-containing protein. (545 aa)
	LOC109508512	Si:dkey-175m17.7. (863 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNP	LOC109512366	ENSHCOP00000019573	ENSHCOP00000020210	2',3'-cyclic nucleotide 3' phosphodiesterase.	Proteolipid protein 1b.	0.422
CNP	LOC109515913	ENSHCOP00000019573	ENSHCOP00000003651	2',3'-cyclic nucleotide 3' phosphodiesterase.	Proteolipid protein 1a.	0.422
ENSHCOP00000022196	ENSHCOP00000022759	ENSHCOP00000022196	ENSHCOP00000022759	Uncharacterized protein.	Alpha-carbonic anhydrase domain-containing protein.	0.874
ENSHCOP00000022196	cntn2	ENSHCOP00000022196	ENSHCOP00000003256	Uncharacterized protein.	Contactin 2.	0.472
ENSHCOP00000022759	ENSHCOP00000022196	ENSHCOP00000022759	ENSHCOP00000022196	Alpha-carbonic anhydrase domain-containing protein.	Uncharacterized protein.	0.874
ENSHCOP00000022759	cntn2	ENSHCOP00000022759	ENSHCOP00000003256	Alpha-carbonic anhydrase domain-containing protein.	Contactin 2.	0.472
ENSHCOP00000023388	LOC109523037	ENSHCOP00000023388	ENSHCOP00000022017	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.620
ENSHCOP00000023388	LOC109523373	ENSHCOP00000023388	ENSHCOP00000016238	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.910
ENSHCOP00000023388	Nkx2-2	ENSHCOP00000023388	ENSHCOP00000012759	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	NK2 homeobox 2a.	0.561
ENSHCOP00000023388	ihh	ENSHCOP00000023388	ENSHCOP00000006137	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.910
ENSHCOP00000023388	nkx6-1	ENSHCOP00000023388	ENSHCOP00000010497	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	NK6 homeobox 1.	0.434
ENSHCOP00000023388	sox10	ENSHCOP00000023388	ENSHCOP00000020220	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	SRY-box transcription factor 10.	0.430
LOC109506899	LOC109515541	ENSHCOP00000027854	ENSHCOP00000010535	ABC transmembrane type-1 domain-containing protein.	ABC transporter domain-containing protein.	0.940
LOC109510758	LOC109523037	ENSHCOP00000014894	ENSHCOP00000022017	Transforming growth factor beta; Belongs to the TGF-beta family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.518
LOC109512366	CNP	ENSHCOP00000020210	ENSHCOP00000019573	Proteolipid protein 1b.	2',3'-cyclic nucleotide 3' phosphodiesterase.	0.422
LOC109515541	LOC109506899	ENSHCOP00000010535	ENSHCOP00000027854	ABC transporter domain-containing protein.	ABC transmembrane type-1 domain-containing protein.	0.940
LOC109515913	CNP	ENSHCOP00000003651	ENSHCOP00000019573	Proteolipid protein 1a.	2',3'-cyclic nucleotide 3' phosphodiesterase.	0.422
LOC109515913	sox10	ENSHCOP00000003651	ENSHCOP00000020220	Proteolipid protein 1a.	SRY-box transcription factor 10.	0.505
LOC109517921	wasf3	ENSHCOP00000017140	ENSHCOP00000026759	WH2 domain-containing protein.	WASP family member 3b.	0.902
LOC109523037	ENSHCOP00000023388	ENSHCOP00000022017	ENSHCOP00000023388	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.620