(60 nodes) Negative regulation of inflammatory response network (Hippocampus comes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gpr17	G protein-coupled receptor 17. (339 aa)
	LOC109508512	Si:dkey-175m17.7. (863 aa)
	psmb4	Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
	ENSHCOP00000026803	Granulin b. (551 aa)
	LOC109524153	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (471 aa)
	socs3	Suppressor of cytokine signaling 3a. (204 aa)
	NT5E	5'-nucleotidase, ecto (CD73); Belongs to the 5'-nucleotidase family. (574 aa)
	LOC109523178	Leucine rich repeat and fibronectin type III domain containing 5b. (794 aa)
	mfhas1	Malignant fibrous histiocytoma amplified sequence 1. (1096 aa)
	nlrx1	NLR family member X1. (968 aa)
	CCN3	Cellular communication network factor 3. (339 aa)
	lrfn5	Leucine rich repeat and fibronectin type III domain containing 5a. (545 aa)
	LOC109518018	RAB guanine nucleotide exchange factor (GEF) 1. (502 aa)
	il10	Uncharacterized protein. (236 aa)
	ash1l	Uncharacterized protein. (1859 aa)
	ENSHCOP00000020293	WAP four-disulfide core domain 1. (218 aa)
	nr1d2	Nuclear receptor subfamily 1, group D, member 2a. (588 aa)
	rb1	Retinoblastoma 1. (903 aa)
	LOC109518424	RAB guanine nucleotide exchange factor (GEF) 1, like. (479 aa)
	LOC109517754	Nuclear receptor subfamily 1, group H, member 5. (488 aa)
	LOC109529183	Uncharacterized protein. (477 aa)
	PPARG	Peroxisome proliferator activated receptor gamma. (575 aa)
	LOC109531321	Nuclear receptor subfamily 1, group D, member 4a. (571 aa)
	tafa3	Uncharacterized protein. (128 aa)
	sharpin	SHANK-associated RH domain interacting protein. (490 aa)
	ENSHCOP00000014775	Insulin-like growth factor 1. (181 aa)
	LOC109510188	Uncharacterized protein. (246 aa)
	LOC109515323	Tumor necrosis factor receptor superfamily, member 1a. (383 aa)
	lpcat3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (480 aa)
	tnfaip6	Tumor necrosis factor, alpha-induced protein 6. (263 aa)
	cunh5orf30	Zgc:194281. (213 aa)
	ghsr	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family. (365 aa)
	ENSHCOP00000010512	Uncharacterized protein. (148 aa)
	LOC109527547	Uncharacterized protein. (214 aa)
	LOC109523728	Peroxisome proliferator-activated receptor alpha a. (479 aa)
	proc	Uncharacterized protein. (439 aa)
	LOC109518842	Fibronectin type-III domain-containing protein. (306 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (476 aa)
	LOC109527673	GRANULINS domain-containing protein. (188 aa)
	acod1	Aconitate decarboxylase 1. (506 aa)
	gps2	G protein pathway suppressor 2. (339 aa)
	mvk	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (398 aa)
	metrnl	Meteorin like, glial cell differentiation regulator a. (297 aa)
	vps35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (798 aa)
	smpdl3b	Sphingomyelin phosphodiesterase, acid-like 3B. (612 aa)
	LOC109513802	Phospholipase A(2). (162 aa)
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (771 aa)
	otulin	Uncharacterized protein. (663 aa)
	LOC109517182	Prostaglandin E receptor 4 (subtype EP4) b. (451 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (753 aa)
	il12b	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (355 aa)
	LOC109512344	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (787 aa)
	LOC109521498	Cylindromatosis (turban tumor syndrome), b. (711 aa)
	LOC109526733	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (447 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (430 aa)
	dusp10	Dual specificity phosphatase 10. (472 aa)
	LOC109513128	Ash1 (absent, small, or homeotic)-like (Drosophila). (2930 aa)
	LOC109528302	Uncharacterized protein. (267 aa)
	LOC109530508	WAP four-disulfide core domain 1. (193 aa)
	Fndc4	Fibronectin type III domain containing 4a. (227 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHCOP00000014775	il10	ENSHCOP00000014775	ENSHCOP00000021361	Insulin-like growth factor 1.	Uncharacterized protein.	0.485
LOC109515323	LOC109521498	ENSHCOP00000014336	ENSHCOP00000002314	Tumor necrosis factor receptor superfamily, member 1a.	Cylindromatosis (turban tumor syndrome), b.	0.954
LOC109515323	LOC109529183	ENSHCOP00000014336	ENSHCOP00000016623	Tumor necrosis factor receptor superfamily, member 1a.	Uncharacterized protein.	0.719
LOC109515323	cyld	ENSHCOP00000014336	ENSHCOP00000000209	Tumor necrosis factor receptor superfamily, member 1a.	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	0.954
LOC109515323	il10	ENSHCOP00000014336	ENSHCOP00000021361	Tumor necrosis factor receptor superfamily, member 1a.	Uncharacterized protein.	0.732
LOC109515323	sharpin	ENSHCOP00000014336	ENSHCOP00000015239	Tumor necrosis factor receptor superfamily, member 1a.	SHANK-associated RH domain interacting protein.	0.971
LOC109515323	tnfaip3	ENSHCOP00000014336	ENSHCOP00000001357	Tumor necrosis factor receptor superfamily, member 1a.	Tumor necrosis factor, alpha-induced protein 3.	0.983
LOC109517754	nr1d2	ENSHCOP00000018947	ENSHCOP00000020091	Nuclear receptor subfamily 1, group H, member 5.	Nuclear receptor subfamily 1, group D, member 2a.	0.770
LOC109518018	LOC109518424	ENSHCOP00000022637	ENSHCOP00000019217	RAB guanine nucleotide exchange factor (GEF) 1.	RAB guanine nucleotide exchange factor (GEF) 1, like.	0.543
LOC109518018	vps35	ENSHCOP00000022637	ENSHCOP00000005995	RAB guanine nucleotide exchange factor (GEF) 1.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.620
LOC109518424	LOC109518018	ENSHCOP00000019217	ENSHCOP00000022637	RAB guanine nucleotide exchange factor (GEF) 1, like.	RAB guanine nucleotide exchange factor (GEF) 1.	0.543
LOC109518424	vps35	ENSHCOP00000019217	ENSHCOP00000005995	RAB guanine nucleotide exchange factor (GEF) 1, like.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.620
LOC109521498	LOC109515323	ENSHCOP00000002314	ENSHCOP00000014336	Cylindromatosis (turban tumor syndrome), b.	Tumor necrosis factor receptor superfamily, member 1a.	0.954
LOC109521498	otulin	ENSHCOP00000002314	ENSHCOP00000000338	Cylindromatosis (turban tumor syndrome), b.	Uncharacterized protein.	0.407
LOC109521498	sharpin	ENSHCOP00000002314	ENSHCOP00000015239	Cylindromatosis (turban tumor syndrome), b.	SHANK-associated RH domain interacting protein.	0.663
LOC109523728	PPARA	ENSHCOP00000010212	ENSHCOP00000003218	Peroxisome proliferator-activated receptor alpha a.	Peroxisome proliferator-activated receptor alpha b.	0.901
LOC109523728	nr1d2	ENSHCOP00000010212	ENSHCOP00000020091	Peroxisome proliferator-activated receptor alpha a.	Nuclear receptor subfamily 1, group D, member 2a.	0.630
LOC109527547	il10	ENSHCOP00000010223	ENSHCOP00000021361	Uncharacterized protein.	Uncharacterized protein.	0.424
LOC109527547	socs3	ENSHCOP00000010223	ENSHCOP00000025365	Uncharacterized protein.	Suppressor of cytokine signaling 3a.	0.903
LOC109529183	LOC109515323	ENSHCOP00000016623	ENSHCOP00000014336	Uncharacterized protein.	Tumor necrosis factor receptor superfamily, member 1a.	0.719