(54 nodes) Positive regulation of inflammatory response network (Hippocampus comes)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109524153	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (471 aa)
	LOC109525032	Vesicle-associated membrane protein 8 (endobrevin). (122 aa)
	LGALS2	Galectin. (120 aa)
	ENSHCOP00000005332	Uncharacterized protein. (303 aa)
	Il16	Uncharacterized protein. (713 aa)
	LOC109519522	ANK_REP_REGION domain-containing protein. (340 aa)
	LOC109511308	Galectin. (127 aa)
	ENSHCOP00000007987	CCAAT enhancer binding protein beta. (289 aa)
	tnfrsf11a	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator. (595 aa)
	LOC109517017	IGFBP N-terminal domain-containing protein. (126 aa)
	LOC109519438	C2 calcium dependent domain containing 4A. (440 aa)
	ENSHCOP00000010646	Cellular communication network factor 4a. (146 aa)
	ENSHCOP00000010767	Uncharacterized protein. (705 aa)
	ENSHCOP00000011594	Uncharacterized protein. (127 aa)
	napepld	N-acyl phosphatidylethanolamine phospholipase D. (396 aa)
	ctsc	Cathepsin C; Belongs to the peptidase C1 family. (459 aa)
	LOC109513432	Interleukin-1. (238 aa)
	LOC109507479	ZP domain-containing protein. (422 aa)
	ENSHCOP00000013336	Protein kinase domain-containing protein. (472 aa)
	ENSHCOP00000013347	Uncharacterized protein. (1158 aa)
	LOC109515323	Tumor necrosis factor receptor superfamily, member 1a. (383 aa)
	Gpr4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	tafa3	Uncharacterized protein. (128 aa)
	LOC109508122	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (283 aa)
	ENSHCOP00000016175	G protein-coupled receptor, class C, group 5, member Bb. (398 aa)
	LOC109511442	Programmed cell death 4a. (468 aa)
	LOC109520007	G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	LOC109531926	Lipoprotein lipase. (284 aa)
	serpine1	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (392 aa)
	LOC109518426	Uncharacterized protein; Belongs to the peptidase C14A family. (392 aa)
	LOC109526980	Galectin. (134 aa)
	LOC109515286	G_PROTEIN_RECEP_F1_2 domain-containing protein. (338 aa)
	tnip1	TNFAIP3 interacting protein 1. (670 aa)
	ptgs2	Prostaglandin-endoperoxide synthase 2b. (608 aa)
	ninj1	Ninjurin 1. (141 aa)
	ENSHCOP00000021940	SEFIR domain-containing protein. (737 aa)
	ENSHCOP00000022191	Uncharacterized protein. (279 aa)
	LOC109522968	ZP domain-containing protein. (419 aa)
	ENSHCOP00000023344	Si:dkey-211g8.6. (299 aa)
	LOC109512265	PYD and CARD domain containing. (208 aa)
	snx4	Sorting nexin 4. (438 aa)
	LOC109509783	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (308 aa)
	gprc5b	G protein-coupled receptor, class C, group 5, member Ba. (406 aa)
	C2CD4C	C2 calcium dependent domain containing 4C. (418 aa)
	setd4	SET domain containing 4. (409 aa)
	LOC109518427	Uncharacterized protein; Belongs to the peptidase C14A family. (396 aa)
	LOC109526733	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (447 aa)
	tnfsf11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (266 aa)
	kars1	Lysine--tRNA ligase. (598 aa)
	nupr1	Nuclear protein 1b. (74 aa)
	LOC109532313	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (520 aa)
	LOC109517182	Prostaglandin E receptor 4 (subtype EP4) b. (451 aa)
	pdcd4	Programmed cell death 4b. (473 aa)
	LOC109507285	C2 domain-containing protein. (428 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHCOP00000005332	Il16	ENSHCOP00000005332	ENSHCOP00000005350	Uncharacterized protein.	Uncharacterized protein.	0.901
ENSHCOP00000010646	LOC109517017	ENSHCOP00000010646	ENSHCOP00000009737	Cellular communication network factor 4a.	IGFBP N-terminal domain-containing protein.	0.915
ENSHCOP00000011594	LOC109512265	ENSHCOP00000011594	ENSHCOP00000023694	Uncharacterized protein.	PYD and CARD domain containing.	0.623
ENSHCOP00000011594	LOC109513432	ENSHCOP00000011594	ENSHCOP00000012063	Uncharacterized protein.	Interleukin-1.	0.742
ENSHCOP00000011594	LOC109518426	ENSHCOP00000011594	ENSHCOP00000019375	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.606
ENSHCOP00000011594	LOC109518427	ENSHCOP00000011594	ENSHCOP00000003168	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.606
ENSHCOP00000013336	ENSHCOP00000013347	ENSHCOP00000013336	ENSHCOP00000013347	Protein kinase domain-containing protein.	Uncharacterized protein.	0.945
ENSHCOP00000013347	ENSHCOP00000013336	ENSHCOP00000013347	ENSHCOP00000013336	Uncharacterized protein.	Protein kinase domain-containing protein.	0.945
ENSHCOP00000016175	LGALS2	ENSHCOP00000016175	ENSHCOP00000005001	G protein-coupled receptor, class C, group 5, member Bb.	Galectin.	0.471
Il16	ENSHCOP00000005332	ENSHCOP00000005350	ENSHCOP00000005332	Uncharacterized protein.	Uncharacterized protein.	0.901
Il16	LOC109513432	ENSHCOP00000005350	ENSHCOP00000012063	Uncharacterized protein.	Interleukin-1.	0.411
LGALS2	ENSHCOP00000016175	ENSHCOP00000005001	ENSHCOP00000016175	Galectin.	G protein-coupled receptor, class C, group 5, member Bb.	0.471
LGALS2	gprc5b	ENSHCOP00000005001	ENSHCOP00000027105	Galectin.	G protein-coupled receptor, class C, group 5, member Ba.	0.471
LOC109508122	LOC109513432	ENSHCOP00000016027	ENSHCOP00000012063	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	Interleukin-1.	0.523
LOC109509783	LOC109513432	ENSHCOP00000026447	ENSHCOP00000012063	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	Interleukin-1.	0.523
LOC109509783	LOC109519522	ENSHCOP00000026447	ENSHCOP00000006784	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	ANK_REP_REGION domain-containing protein.	0.905
LOC109512265	ENSHCOP00000011594	ENSHCOP00000023694	ENSHCOP00000011594	PYD and CARD domain containing.	Uncharacterized protein.	0.623
LOC109512265	LOC109513432	ENSHCOP00000023694	ENSHCOP00000012063	PYD and CARD domain containing.	Interleukin-1.	0.790
LOC109512265	LOC109518426	ENSHCOP00000023694	ENSHCOP00000019375	PYD and CARD domain containing.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.987
LOC109512265	LOC109518427	ENSHCOP00000023694	ENSHCOP00000003168	PYD and CARD domain containing.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.987