(40 nodes) Regulation of pattern recognition receptor signaling pathway network (Hippocampus comes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	sarm1	Sterile alpha and TIR motif containing 1. (710 aa)
	LOC109519176	Solute carrier family 15 member 2. (664 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (753 aa)
	CXorf21	Uncharacterized protein. (319 aa)
	LOC109524315	Tetraspanin. (251 aa)
	LOC109525911	Cytochrome b-245, alpha polypeptide. (154 aa)
	appl2	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2. (663 aa)
	ufd1	Ubiquitin recognition factor in ER associated degradation 1. (310 aa)
	smpdl3b	Sphingomyelin phosphodiesterase, acid-like 3B. (612 aa)
	riok3	Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (517 aa)
	slc46a2	Solute carrier family 46 member 2. (457 aa)
	lgr4	Leucine-rich repeat containing G protein-coupled receptor 4. (980 aa)
	gps2	G protein pathway suppressor 2. (339 aa)
	ENSHCOP00000007014	Interleukin-1 receptor-associated kinase 3. (331 aa)
	acod1	Aconitate decarboxylase 1. (506 aa)
	LOC109530495	Interferon regulatory factor 7. (399 aa)
	nfkbil1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1. (335 aa)
	LOC109528314	Uncharacterized protein. (684 aa)
	c1qbp	Complement component 1, q subcomponent binding protein. (285 aa)
	ENSHCOP00000009710	Si:ch73-174h16.4. (288 aa)
	gramd4	GRAM domain containing 4a. (535 aa)
	ENSHCOP00000014612	Interferon regulatory factor 1a. (163 aa)
	LOC109531321	Nuclear receptor subfamily 1, group D, member 4a. (571 aa)
	dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58. (673 aa)
	ENSHCOP00000019638	Uncharacterized protein. (114 aa)
	pum1	Pumilio RNA-binding family member 1. (1036 aa)
	gpatch3	G patch domain containing 3. (510 aa)
	ninj1	Ninjurin 1. (141 aa)
	TLR5	Toll like receptor 5; Belongs to the Toll-like receptor family. (883 aa)
	LOC109515677	Interferon regulatory factor. (319 aa)
	LOC109516798	Pumilio RNA-binding family member 2. (1270 aa)
	LOC109522997	GRAM domain containing 4b. (611 aa)
	nlrx1	NLR family member X1. (968 aa)
	mfhas1	Malignant fibrous histiocytoma amplified sequence 1. (1096 aa)
	slc15a4	Solute carrier family 15 member 4. (502 aa)
	ENSHCOP00000024917	Uncharacterized protein. (416 aa)
	appl1	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. (709 aa)
	otud4	OTU domain-containing protein. (892 aa)
	tkfc	Triokinase/FMN cyclase. (534 aa)
	nop53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (478 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CXorf21	slc15a4	ENSHCOP00000002177	ENSHCOP00000024744	Uncharacterized protein.	Solute carrier family 15 member 4.	0.436
ENSHCOP00000007014	LOC109528314	ENSHCOP00000007014	ENSHCOP00000008416	Interleukin-1 receptor-associated kinase 3.	Uncharacterized protein.	0.400
ENSHCOP00000007014	TLR5	ENSHCOP00000007014	ENSHCOP00000021195	Interleukin-1 receptor-associated kinase 3.	Toll like receptor 5; Belongs to the Toll-like receptor family.	0.400
ENSHCOP00000014612	LOC109515677	ENSHCOP00000014612	ENSHCOP00000021584	Interferon regulatory factor 1a.	Interferon regulatory factor.	0.904
ENSHCOP00000019638	pum1	ENSHCOP00000019638	ENSHCOP00000019643	Uncharacterized protein.	Pumilio RNA-binding family member 1.	0.896
LOC109515677	ENSHCOP00000014612	ENSHCOP00000021584	ENSHCOP00000014612	Interferon regulatory factor.	Interferon regulatory factor 1a.	0.904
LOC109515677	LOC109530495	ENSHCOP00000021584	ENSHCOP00000007522	Interferon regulatory factor.	Interferon regulatory factor 7.	0.498
LOC109515677	dhx58	ENSHCOP00000021584	ENSHCOP00000019409	Interferon regulatory factor.	DEXH (Asp-Glu-X-His) box polypeptide 58.	0.460
LOC109528314	ENSHCOP00000007014	ENSHCOP00000008416	ENSHCOP00000007014	Uncharacterized protein.	Interleukin-1 receptor-associated kinase 3.	0.400
LOC109528314	TLR5	ENSHCOP00000008416	ENSHCOP00000021195	Uncharacterized protein.	Toll like receptor 5; Belongs to the Toll-like receptor family.	0.903
LOC109530495	LOC109515677	ENSHCOP00000007522	ENSHCOP00000021584	Interferon regulatory factor 7.	Interferon regulatory factor.	0.498
LOC109530495	dhx58	ENSHCOP00000007522	ENSHCOP00000019409	Interferon regulatory factor 7.	DEXH (Asp-Glu-X-His) box polypeptide 58.	0.786
LOC109530495	nlrx1	ENSHCOP00000007522	ENSHCOP00000023729	Interferon regulatory factor 7.	NLR family member X1.	0.508
LOC109531321	gps2	ENSHCOP00000016083	ENSHCOP00000006978	Nuclear receptor subfamily 1, group D, member 4a.	G protein pathway suppressor 2.	0.837
TLR5	ENSHCOP00000007014	ENSHCOP00000021195	ENSHCOP00000007014	Toll like receptor 5; Belongs to the Toll-like receptor family.	Interleukin-1 receptor-associated kinase 3.	0.400
TLR5	LOC109528314	ENSHCOP00000021195	ENSHCOP00000008416	Toll like receptor 5; Belongs to the Toll-like receptor family.	Uncharacterized protein.	0.903
appl1	appl2	ENSHCOP00000025191	ENSHCOP00000004184	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	0.995
appl2	appl1	ENSHCOP00000004184	ENSHCOP00000025191	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.	0.995
dhx58	LOC109515677	ENSHCOP00000019409	ENSHCOP00000021584	DEXH (Asp-Glu-X-His) box polypeptide 58.	Interferon regulatory factor.	0.460
dhx58	LOC109530495	ENSHCOP00000019409	ENSHCOP00000007522	DEXH (Asp-Glu-X-His) box polypeptide 58.	Interferon regulatory factor 7.	0.786