(42 nodes) Neuron death network (Hippocampus comes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dnajc5g	DnaJ (Hsp40) homolog, subfamily C, member 5 gamma a. (220 aa)
	lig4	DNA ligase. (910 aa)
	LOC109522556	Citron rho-interacting serine/threonine kinase a; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2121 aa)
	siah1	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (282 aa)
	adnp	Activity-dependent neuroprotector homeobox b. (1032 aa)
	FADD	Fas associated via death domain. (188 aa)
	sncb	Beta-synuclein; Belongs to the synuclein family. (117 aa)
	LOC109524982	Citron rho-interacting serine/threonine kinase b. (1567 aa)
	rb1	Retinoblastoma 1. (903 aa)
	LOC109516987	Family with sequence similarity 162 member A. (158 aa)
	LOC109514524	Uncharacterized protein. (259 aa)
	diablo	Diablo, IAP-binding mitochondrial protein a. (240 aa)
	LOC109527656	TLC domain-containing protein. (283 aa)
	ENSHCOP00000008221	J domain-containing protein. (167 aa)
	LOC109512940	DnaJ (Hsp40) homolog, subfamily C, member 5aa. (199 aa)
	aifm1	Apoptosis inducing factor mitochondrion associated 1. (685 aa)
	tnfrsf21	Tumor necrosis factor receptor superfamily, member 21. (665 aa)
	casp9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (477 aa)
	cdk5	Cyclin-dependent kinase 5. (258 aa)
	bag5	BCL2 associated athanogene 5. (579 aa)
	ENSHCOP00000013347	Uncharacterized protein. (1158 aa)
	ENSHCOP00000013336	Protein kinase domain-containing protein. (472 aa)
	ENSHCOP00000013090	Spatacsin_C domain-containing protein. (523 aa)
	ppargc1a	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (915 aa)
	LOC109524107	Nuclear factor of activated T cells 4. (805 aa)
	NCSTN	Nicastrin. (701 aa)
	LOC109518914	J domain-containing protein. (199 aa)
	nf1	Neurofibromin 1b. (2754 aa)
	Atm	TAN domain-containing protein. (311 aa)
	ENSHCOP00000009180	Uncharacterized protein. (169 aa)
	Bhlhe23	Basic helix-loop-helix family, member e23. (226 aa)
	pjvk	Pejvakin. (361 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	cln8	CLN8 transmembrane ER and ERGIC protein. (280 aa)
	ENSHCOP00000026573	CLN8 transmembrane ER and ERGIC protein. (291 aa)
	bax	BCL2 associated X, apoptosis regulator a. (255 aa)
	LOC109517388	J domain-containing protein. (219 aa)
	ENSHCOP00000025797	Uncharacterized protein. (519 aa)
	LOC109529430	J domain-containing protein. (198 aa)
	tmtc4	Transmembrane O-mannosyltransferase targeting cadherins 4. (714 aa)
	ENSHCOP00000027784	Phosphatidylinositol glycan anchor biosynthesis, class T. (543 aa)
	rapsn	Receptor-associated protein of the synapse, 43kD. (412 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atm	ENSHCOP00000009180	ENSHCOP00000009193	ENSHCOP00000009180	TAN domain-containing protein.	Uncharacterized protein.	0.929
Atm	lig4	ENSHCOP00000009193	ENSHCOP00000023467	TAN domain-containing protein.	DNA ligase.	0.604
Atm	nf1	ENSHCOP00000009193	ENSHCOP00000010037	TAN domain-containing protein.	Neurofibromin 1b.	0.419
ENSHCOP00000009180	Atm	ENSHCOP00000009180	ENSHCOP00000009193	Uncharacterized protein.	TAN domain-containing protein.	0.929
ENSHCOP00000009180	lig4	ENSHCOP00000009180	ENSHCOP00000023467	Uncharacterized protein.	DNA ligase.	0.604
ENSHCOP00000009180	nf1	ENSHCOP00000009180	ENSHCOP00000010037	Uncharacterized protein.	Neurofibromin 1b.	0.419
ENSHCOP00000013090	ENSHCOP00000025797	ENSHCOP00000013090	ENSHCOP00000025797	Spatacsin_C domain-containing protein.	Uncharacterized protein.	0.899
ENSHCOP00000013336	ENSHCOP00000013347	ENSHCOP00000013336	ENSHCOP00000013347	Protein kinase domain-containing protein.	Uncharacterized protein.	0.945
ENSHCOP00000013347	ENSHCOP00000013336	ENSHCOP00000013347	ENSHCOP00000013336	Uncharacterized protein.	Protein kinase domain-containing protein.	0.945
ENSHCOP00000025797	ENSHCOP00000013090	ENSHCOP00000025797	ENSHCOP00000013090	Uncharacterized protein.	Spatacsin_C domain-containing protein.	0.899
FADD	casp9	ENSHCOP00000020973	ENSHCOP00000004962	Fas associated via death domain.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.710
LOC109514524	aifm1	ENSHCOP00000015261	ENSHCOP00000006723	Uncharacterized protein.	Apoptosis inducing factor mitochondrion associated 1.	0.471
LOC109514524	bax	ENSHCOP00000015261	ENSHCOP00000026539	Uncharacterized protein.	BCL2 associated X, apoptosis regulator a.	0.417
LOC109514524	casp9	ENSHCOP00000015261	ENSHCOP00000004962	Uncharacterized protein.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.704
LOC109514524	diablo	ENSHCOP00000015261	ENSHCOP00000015242	Uncharacterized protein.	Diablo, IAP-binding mitochondrial protein a.	0.904
NCSTN	aifm1	ENSHCOP00000010670	ENSHCOP00000006723	Nicastrin.	Apoptosis inducing factor mitochondrion associated 1.	0.413
NCSTN	cdk5	ENSHCOP00000010670	ENSHCOP00000003695	Nicastrin.	Cyclin-dependent kinase 5.	0.407
aifm1	LOC109514524	ENSHCOP00000006723	ENSHCOP00000015261	Apoptosis inducing factor mitochondrion associated 1.	Uncharacterized protein.	0.471
aifm1	NCSTN	ENSHCOP00000006723	ENSHCOP00000010670	Apoptosis inducing factor mitochondrion associated 1.	Nicastrin.	0.413
aifm1	bax	ENSHCOP00000006723	ENSHCOP00000026539	Apoptosis inducing factor mitochondrion associated 1.	BCL2 associated X, apoptosis regulator a.	0.923