39 items (Hippocampus comes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109517903	Crystallin, alpha B, a; Belongs to the small heat shock protein (HSP20) family. (164 aa)
	map3k20	Uncharacterized protein. (788 aa)
	ENSHCOP00000009180	Uncharacterized protein. (169 aa)
	Atm	TAN domain-containing protein. (311 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (839 aa)
	fbxo4	F-box protein 4. (364 aa)
	brca1	Uncharacterized protein. (1141 aa)
	chek2	Checkpoint kinase 2. (518 aa)
	LOC109509577	Uncharacterized protein. (194 aa)
	xrcc5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (729 aa)
	Atr	Uncharacterized protein. (106 aa)
	LOC109521589	Deoxyribonuclease; Belongs to the DNase I family. (272 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
	lig4	DNA ligase. (910 aa)
	rad1	RAD1 homolog (S. pombe). (279 aa)
	blm	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (966 aa)
	ENSHCOP00000023012	Uncharacterized protein. (1155 aa)
	cdca7l	Cell division cycle associated 7b. (396 aa)
	LOC109510758	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	xrcc6	X-ray repair complementing defective repair in Chinese hamster cells 6. (609 aa)
	ENSHCOP00000019285	Deacetylase sirtuin-type domain-containing protein. (166 aa)
	ect2	Epithelial cell transforming 2. (848 aa)
	ENSHCOP00000000931	Protein kinase domain-containing protein. (480 aa)
	LOC109525531	Uncharacterized protein. (324 aa)
	LOC109523155	Sirtuin 1. (657 aa)
	ENSHCOP00000019306	Sirtuin 1. (369 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1495 aa)
	Rad9b	Uncharacterized protein. (173 aa)
	sfrp2	Secreted frizzled-related protein 2. (299 aa)
	rad51ap1	RAD51_interact domain-containing protein. (275 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (471 aa)
	LOC109531265	BRCA1 associated RING domain 1. (783 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (382 aa)
	ENSHCOP00000013471	TBD domain-containing protein. (231 aa)
	ENSHCOP00000013487	Uncharacterized protein. (93 aa)
	ENSHCOP00000014556	Uncharacterized protein. (241 aa)
	ino80	INO80 complex ATPase subunit. (1543 aa)
	Spidr	DUF4503 domain-containing protein. (454 aa)
	itgb6	Integrin beta; Belongs to the integrin beta chain family. (775 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atm	Atr	ENSHCOP00000009193	ENSHCOP00000025135	TAN domain-containing protein.	Uncharacterized protein.	0.997
Atm	ENSHCOP00000009180	ENSHCOP00000009193	ENSHCOP00000009180	TAN domain-containing protein.	Uncharacterized protein.	0.929
Atm	ENSHCOP00000014556	ENSHCOP00000009193	ENSHCOP00000014556	TAN domain-containing protein.	Uncharacterized protein.	0.598
Atm	ENSHCOP00000023012	ENSHCOP00000009193	ENSHCOP00000023012	TAN domain-containing protein.	Uncharacterized protein.	0.887
Atm	LOC109531265	ENSHCOP00000009193	ENSHCOP00000006973	TAN domain-containing protein.	BRCA1 associated RING domain 1.	0.898
Atm	Rad9b	ENSHCOP00000009193	ENSHCOP00000004340	TAN domain-containing protein.	Uncharacterized protein.	0.839
Atm	blm	ENSHCOP00000009193	ENSHCOP00000023146	TAN domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.909
Atm	brca1	ENSHCOP00000009193	ENSHCOP00000016663	TAN domain-containing protein.	Uncharacterized protein.	0.968
Atm	cdca7l	ENSHCOP00000009193	ENSHCOP00000022768	TAN domain-containing protein.	Cell division cycle associated 7b.	0.717
Atm	chek2	ENSHCOP00000009193	ENSHCOP00000017184	TAN domain-containing protein.	Checkpoint kinase 2.	0.994
Atm	lig4	ENSHCOP00000009193	ENSHCOP00000023467	TAN domain-containing protein.	DNA ligase.	0.604
Atm	rad1	ENSHCOP00000009193	ENSHCOP00000023294	TAN domain-containing protein.	RAD1 homolog (S. pombe).	0.898
Atm	rad51	ENSHCOP00000009193	ENSHCOP00000024035	TAN domain-containing protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.923
Atm	rad51ap1	ENSHCOP00000009193	ENSHCOP00000005844	TAN domain-containing protein.	RAD51_interact domain-containing protein.	0.610
Atm	rad9a	ENSHCOP00000009193	ENSHCOP00000007720	TAN domain-containing protein.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.839
Atm	tp53bp1	ENSHCOP00000009193	ENSHCOP00000020451	TAN domain-containing protein.	Tumor protein p53 binding protein, 1.	0.974
Atm	xrcc5	ENSHCOP00000009193	ENSHCOP00000026645	TAN domain-containing protein.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.910
Atm	xrcc6	ENSHCOP00000009193	ENSHCOP00000007729	TAN domain-containing protein.	X-ray repair complementing defective repair in Chinese hamster cells 6.	0.917
Atr	Atm	ENSHCOP00000025135	ENSHCOP00000009193	Uncharacterized protein.	TAN domain-containing protein.	0.997
Atr	ENSHCOP00000009180	ENSHCOP00000025135	ENSHCOP00000009180	Uncharacterized protein.	Uncharacterized protein.	0.971