65 items (Hippocampus comes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rev1	REV1 DNA directed polymerase. (809 aa)
	pold4	Si:dkey-28b4.7. (106 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (611 aa)
	dkc1	Dyskeratosis congenita 1, dyskerin. (504 aa)
	ENSHCOP00000008158	Spermatogenesis associated 22. (366 aa)
	lig3	DNA ligase. (993 aa)
	pot1	Protection of telomeres 1 homolog. (842 aa)
	pclaf	PCNA clamp associated factor. (121 aa)
	polb	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (336 aa)
	terf1	TRF domain-containing protein. (431 aa)
	terf2	HTH myb-type domain-containing protein. (606 aa)
	phb	Prohibitin. (271 aa)
	cdkn2d	Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (162 aa)
	ENSHCOP00000013551	Uncharacterized protein. (1184 aa)
	LOC109520749	Uncharacterized protein. (534 aa)
	poll	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (560 aa)
	vcp	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	poldip2	Polymerase (DNA-directed), delta interacting protein 2. (375 aa)
	Polk	Polymerase (DNA directed) kappa. (396 aa)
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (521 aa)
	polm	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (498 aa)
	dtl	Denticleless E3 ubiquitin protein ligase homolog (Drosophila). (616 aa)
	dntt	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (499 aa)
	tert	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1065 aa)
	rev3l	REV3 like, DNA directed polymerase zeta catalytic subunit. (2836 aa)
	zbtb1	Zinc finger and BTB domain containing 1. (626 aa)
	ENSHCOP00000005702	Uncharacterized protein. (1062 aa)
	ENSHCOP00000005725	Reverse transcriptase domain-containing protein. (990 aa)
	sprtn	SprT-like N-terminal domain. (405 aa)
	LOC109517068	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (572 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (437 aa)
	Polg	Polymerase (DNA directed), gamma. (449 aa)
	nhp2	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (158 aa)
	poli	Polymerase (DNA directed) iota. (621 aa)
	wrnip1	WRN helicase interacting protein 1. (591 aa)
	ENSHCOP00000017437	Uncharacterized protein. (557 aa)
	LOC109512331	UmuC domain-containing protein. (184 aa)
	ENSHCOP00000018261	Uncharacterized protein. (110 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1285 aa)
	hrob	Si:dkey-260c8.8. (669 aa)
	ENSHCOP00000019285	Deacetylase sirtuin-type domain-containing protein. (166 aa)
	ENSHCOP00000019306	Sirtuin 1. (369 aa)
	ENSHCOP00000020936	Uncharacterized protein. (1127 aa)
	pinx1	PIN2 (TERF1) interacting telomerase inhibitor 1. (326 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2282 aa)
	gar1	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (220 aa)
	wrap53	WD repeat containing, antisense to TP53. (533 aa)
	ENSHCOP00000022868	POLAc domain-containing protein. (803 aa)
	lig4	DNA ligase. (910 aa)
	Pola1	DNA polymerase. (1356 aa)
	ENSHCOP00000023803	Uncharacterized protein. (1781 aa)
	lig1	DNA ligase. (902 aa)
	pold1	DNA polymerase. (1105 aa)
	tk1	Thymidine kinase. (231 aa)
	LOC109529379	Prostaglandin E synthase 3a (cytosolic). (159 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (470 aa)
	LOC109520778	Sphingomyelin phosphodiesterase 3, neutral. (626 aa)
	nop10	NOP10 ribonucleoprotein homolog (yeast). (64 aa)
	polh	Polymerase (DNA directed), eta. (483 aa)
	LOC109528575	Prostaglandin E synthase 3b (cytosolic). (187 aa)
	polg2	Polymerase (DNA directed), gamma 2, accessory subunit. (454 aa)
	primpol	Primase and polymerase (DNA-directed). (501 aa)
	LOC109523155	Sirtuin 1. (657 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	telo2	TEL2, telomere maintenance 2, homolog (S. cerevisiae). (813 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHCOP00000018261	Pola1	ENSHCOP00000018261	ENSHCOP00000023742	Uncharacterized protein.	DNA polymerase.	0.415
ENSHCOP00000018261	Polk	ENSHCOP00000018261	ENSHCOP00000011993	Uncharacterized protein.	Polymerase (DNA directed) kappa.	0.419
ENSHCOP00000018261	lig1	ENSHCOP00000018261	ENSHCOP00000023890	Uncharacterized protein.	DNA ligase.	0.431
ENSHCOP00000018261	lig4	ENSHCOP00000018261	ENSHCOP00000023467	Uncharacterized protein.	DNA ligase.	0.453
ENSHCOP00000018261	pcna	ENSHCOP00000018261	ENSHCOP00000003160	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.562
ENSHCOP00000018261	pold1	ENSHCOP00000018261	ENSHCOP00000024706	Uncharacterized protein.	DNA polymerase.	0.429
ENSHCOP00000018261	polg2	ENSHCOP00000018261	ENSHCOP00000027379	Uncharacterized protein.	Polymerase (DNA directed), gamma 2, accessory subunit.	0.421
ENSHCOP00000018261	rad50	ENSHCOP00000018261	ENSHCOP00000018844	Uncharacterized protein.	RAD50 homolog, double strand break repair protein.	0.664
ENSHCOP00000018261	rev1	ENSHCOP00000018261	ENSHCOP00000002495	Uncharacterized protein.	REV1 DNA directed polymerase.	0.441
ENSHCOP00000018261	rev3l	ENSHCOP00000018261	ENSHCOP00000005351	Uncharacterized protein.	REV3 like, DNA directed polymerase zeta catalytic subunit.	0.463
ENSHCOP00000022868	Pola1	ENSHCOP00000022868	ENSHCOP00000023742	POLAc domain-containing protein.	DNA polymerase.	0.516
ENSHCOP00000022868	Polg	ENSHCOP00000022868	ENSHCOP00000008193	POLAc domain-containing protein.	Polymerase (DNA directed), gamma.	0.473
ENSHCOP00000022868	Polk	ENSHCOP00000022868	ENSHCOP00000011993	POLAc domain-containing protein.	Polymerase (DNA directed) kappa.	0.419
ENSHCOP00000022868	lig1	ENSHCOP00000022868	ENSHCOP00000023890	POLAc domain-containing protein.	DNA ligase.	0.431
ENSHCOP00000022868	lig4	ENSHCOP00000022868	ENSHCOP00000023467	POLAc domain-containing protein.	DNA ligase.	0.549
ENSHCOP00000022868	pcna	ENSHCOP00000022868	ENSHCOP00000003160	POLAc domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.650
ENSHCOP00000022868	pold1	ENSHCOP00000022868	ENSHCOP00000024706	POLAc domain-containing protein.	DNA polymerase.	0.429
ENSHCOP00000022868	pole2	ENSHCOP00000022868	ENSHCOP00000010649	POLAc domain-containing protein.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.402
ENSHCOP00000022868	polg2	ENSHCOP00000022868	ENSHCOP00000027379	POLAc domain-containing protein.	Polymerase (DNA directed), gamma 2, accessory subunit.	0.421
ENSHCOP00000022868	rad50	ENSHCOP00000022868	ENSHCOP00000018844	POLAc domain-containing protein.	RAD50 homolog, double strand break repair protein.	0.715