34 items (Hippocampus comes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mecp2	Methyl CpG binding protein 2. (848 aa)
	LOC109523980	Interferon regulatory factor 3. (464 aa)
	ercc4	Excision repair cross-complementation group 4. (900 aa)
	setdb1	SET domain bifurcated histone lysine methyltransferase 1b. (1214 aa)
	LOC109512260	PR domain containing 1a, with ZNF domain. (745 aa)
	PRDM15	PR/SET domain 15. (1103 aa)
	polr2a	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1966 aa)
	LOC109528457	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (376 aa)
	LOC109516796	Uncharacterized protein. (761 aa)
	ENSHCOP00000021751	Uncharacterized protein. (409 aa)
	ENSHCOP00000019306	Sirtuin 1. (369 aa)
	ENSHCOP00000019285	Deacetylase sirtuin-type domain-containing protein. (166 aa)
	pcgf1	Polycomb group ring finger 1. (261 aa)
	LOC109523822	PR domain containing 1b, with ZNF domain. (618 aa)
	ezh2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (701 aa)
	gtf2b	General transcription factor IIB. (224 aa)
	myf5	Myogenic factor. (220 aa)
	taf10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (188 aa)
	ercc1	Excision repair cross-complementation group 1. (338 aa)
	dnmt1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1485 aa)
	egr1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (511 aa)
	LOC109508596	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (771 aa)
	kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (839 aa)
	dhx9	DEAH (Asp-Glu-Ala-His) box helicase 9. (1267 aa)
	rbl1	Retinoblastoma-like 1 (p107). (1010 aa)
	wdr13	WD repeat domain 13. (482 aa)
	MYOD1	Myogenic factor. (279 aa)
	Nup98	Uncharacterized protein. (357 aa)
	ENSHCOP00000006981	Peptidase S59 domain-containing protein. (292 aa)
	znf750	Zinc finger protein 750. (541 aa)
	Bmi1	Bmi1 polycomb ring finger oncogene 1a. (296 aa)
	gtf2f1	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (491 aa)
	LOC109523155	Sirtuin 1. (657 aa)
	pcgf2	Polycomb group ring finger 2. (333 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bmi1	LOC109508596	ENSHCOP00000004179	ENSHCOP00000011065	Bmi1 polycomb ring finger oncogene 1a.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.695
Bmi1	LOC109528457	ENSHCOP00000004179	ENSHCOP00000022970	Bmi1 polycomb ring finger oncogene 1a.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.457
Bmi1	ezh2	ENSHCOP00000004179	ENSHCOP00000017458	Bmi1 polycomb ring finger oncogene 1a.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.695
ENSHCOP00000006981	ENSHCOP00000021751	ENSHCOP00000006981	ENSHCOP00000021751	Peptidase S59 domain-containing protein.	Uncharacterized protein.	0.944
ENSHCOP00000006981	Nup98	ENSHCOP00000006981	ENSHCOP00000006994	Peptidase S59 domain-containing protein.	Uncharacterized protein.	0.930
ENSHCOP00000019285	LOC109508596	ENSHCOP00000019285	ENSHCOP00000011065	Deacetylase sirtuin-type domain-containing protein.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.457
ENSHCOP00000019285	LOC109528457	ENSHCOP00000019285	ENSHCOP00000022970	Deacetylase sirtuin-type domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.735
ENSHCOP00000019285	dnmt1	ENSHCOP00000019285	ENSHCOP00000013439	Deacetylase sirtuin-type domain-containing protein.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.461
ENSHCOP00000019285	ezh2	ENSHCOP00000019285	ENSHCOP00000017458	Deacetylase sirtuin-type domain-containing protein.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.457
ENSHCOP00000019285	kdm1a	ENSHCOP00000019285	ENSHCOP00000010393	Deacetylase sirtuin-type domain-containing protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.442
ENSHCOP00000019306	LOC109508596	ENSHCOP00000019306	ENSHCOP00000011065	Sirtuin 1.	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	0.457
ENSHCOP00000019306	LOC109528457	ENSHCOP00000019306	ENSHCOP00000022970	Sirtuin 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.735
ENSHCOP00000019306	dnmt1	ENSHCOP00000019306	ENSHCOP00000013439	Sirtuin 1.	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.461
ENSHCOP00000019306	ezh2	ENSHCOP00000019306	ENSHCOP00000017458	Sirtuin 1.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.457
ENSHCOP00000019306	kdm1a	ENSHCOP00000019306	ENSHCOP00000010393	Sirtuin 1.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.442
ENSHCOP00000021751	ENSHCOP00000006981	ENSHCOP00000021751	ENSHCOP00000006981	Uncharacterized protein.	Peptidase S59 domain-containing protein.	0.944
ENSHCOP00000021751	Nup98	ENSHCOP00000021751	ENSHCOP00000006994	Uncharacterized protein.	Uncharacterized protein.	0.928
LOC109508596	Bmi1	ENSHCOP00000011065	ENSHCOP00000004179	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Bmi1 polycomb ring finger oncogene 1a.	0.695
LOC109508596	ENSHCOP00000019285	ENSHCOP00000011065	ENSHCOP00000019285	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Deacetylase sirtuin-type domain-containing protein.	0.457
LOC109508596	ENSHCOP00000019306	ENSHCOP00000011065	ENSHCOP00000019306	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Sirtuin 1.	0.457