(20 nodes) Negative regulation of double-strand break repair network (Hippocampus comes)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109507177	Uncharacterized protein. (118 aa)
	ercc6	Excision repair cross-complementation group 6. (1377 aa)
	aunip	Uncharacterized protein. (264 aa)
	parpbp	PARP1 binding protein. (493 aa)
	recql5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (931 aa)
	ubr5	Ubiquitin protein ligase E3 component n-recognin 5. (2539 aa)
	trip12	Thyroid hormone receptor interactor 12. (2055 aa)
	rif1	Replication timing regulatory factor 1. (2634 aa)
	ENSHCOP00000020772	RPA1 related single stranded DNA binding protein. (314 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1495 aa)
	fancb	FA complementation group B. (797 aa)
	OTUB2	OTU deubiquitinase, ubiquitin aldehyde binding 2. (256 aa)
	ENSHCOP00000014695	FAM35_C domain-containing protein. (255 aa)
	LOC109513483	Uncharacterized protein. (223 aa)
	ENSHCOP00000008605	F-box domain-containing protein. (729 aa)
	Hmga2	Uncharacterized protein. (98 aa)
	ogg1	8-oxoguanine DNA glycosylase. (413 aa)
	LOC109512334	Uncharacterized protein. (735 aa)
	rmi2	RecQ mediated genome instability 2. (158 aa)
	otub1	Ubiquitin thioesterase. (266 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHCOP00000008605	ogg1	ENSHCOP00000008605	ENSHCOP00000006361	F-box domain-containing protein.	8-oxoguanine DNA glycosylase.	0.635
ENSHCOP00000008605	recql5	ENSHCOP00000008605	ENSHCOP00000025061	F-box domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.918
ENSHCOP00000008605	tp53bp1	ENSHCOP00000008605	ENSHCOP00000020451	F-box domain-containing protein.	Tumor protein p53 binding protein, 1.	0.701
ENSHCOP00000008605	trip12	ENSHCOP00000008605	ENSHCOP00000024084	F-box domain-containing protein.	Thyroid hormone receptor interactor 12.	0.722
ENSHCOP00000014695	LOC109513483	ENSHCOP00000014695	ENSHCOP00000010698	FAM35_C domain-containing protein.	Uncharacterized protein.	0.949
ENSHCOP00000014695	tp53bp1	ENSHCOP00000014695	ENSHCOP00000020451	FAM35_C domain-containing protein.	Tumor protein p53 binding protein, 1.	0.500
LOC109513483	ENSHCOP00000014695	ENSHCOP00000010698	ENSHCOP00000014695	Uncharacterized protein.	FAM35_C domain-containing protein.	0.949
LOC109513483	tp53bp1	ENSHCOP00000010698	ENSHCOP00000020451	Uncharacterized protein.	Tumor protein p53 binding protein, 1.	0.401
OTUB2	trip12	ENSHCOP00000016156	ENSHCOP00000024084	OTU deubiquitinase, ubiquitin aldehyde binding 2.	Thyroid hormone receptor interactor 12.	0.566
ercc6	ogg1	ENSHCOP00000027896	ENSHCOP00000006361	Excision repair cross-complementation group 6.	8-oxoguanine DNA glycosylase.	0.453
ogg1	ENSHCOP00000008605	ENSHCOP00000006361	ENSHCOP00000008605	8-oxoguanine DNA glycosylase.	F-box domain-containing protein.	0.635
ogg1	ercc6	ENSHCOP00000006361	ENSHCOP00000027896	8-oxoguanine DNA glycosylase.	Excision repair cross-complementation group 6.	0.453
ogg1	recql5	ENSHCOP00000006361	ENSHCOP00000025061	8-oxoguanine DNA glycosylase.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.487
otub1	trip12	ENSHCOP00000002241	ENSHCOP00000024084	Ubiquitin thioesterase.	Thyroid hormone receptor interactor 12.	0.566
parpbp	trip12	ENSHCOP00000026911	ENSHCOP00000024084	PARP1 binding protein.	Thyroid hormone receptor interactor 12.	0.724
recql5	ENSHCOP00000008605	ENSHCOP00000025061	ENSHCOP00000008605	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	F-box domain-containing protein.	0.918
recql5	ogg1	ENSHCOP00000025061	ENSHCOP00000006361	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	8-oxoguanine DNA glycosylase.	0.487
recql5	rmi2	ENSHCOP00000025061	ENSHCOP00000004996	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	RecQ mediated genome instability 2.	0.825
recql5	tp53bp1	ENSHCOP00000025061	ENSHCOP00000020451	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	Tumor protein p53 binding protein, 1.	0.880
rif1	tp53bp1	ENSHCOP00000012872	ENSHCOP00000020451	Replication timing regulatory factor 1.	Tumor protein p53 binding protein, 1.	0.787