30 items (Hippocampus comes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ppargc1a	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (915 aa)
	LOC109521704	Matrin-type domain-containing protein. (1500 aa)
	ENSHCOP00000002848	Si:ch73-281i18.7. (151 aa)
	thrap3	Thyroid hormone receptor associated protein 3b. (862 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	ENSHCOP00000003363	COE1_DBD domain-containing protein. (162 aa)
	map7	Si:ch73-217b7.1. (762 aa)
	LOC109518000	Kruppel-like factor 5 like. (418 aa)
	med19	Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (253 aa)
	med21	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (145 aa)
	LOC109511338	EBF transcription factor 2. (580 aa)
	med22	Mediator complex subunit 22. (202 aa)
	LOC109508304	IPT/TIG domain-containing protein. (552 aa)
	LOC109530282	Retinoid X receptor, alpha a. (444 aa)
	ncor2	Nuclear receptor corepressor 2. (2225 aa)
	fam120b	Family with sequence similarity 120B. (724 aa)
	med18	Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (209 aa)
	klf5	Progesterone immunomodulatory binding factor 1. (438 aa)
	MED26	Mediator complex subunit 26. (598 aa)
	LOC109511945	MAP7 domain containing 3. (707 aa)
	ebf1	EBF transcription factor 1b. (517 aa)
	med11	Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (118 aa)
	med9	Mediator of RNA polymerase II transcription subunit 9; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (99 aa)
	LOC109526528	IPT/TIG domain-containing protein. (400 aa)
	med29	Mediator complex subunit 29. (174 aa)
	LOC109518573	Uncharacterized protein. (471 aa)
	ncor1	Nuclear receptor corepressor 1. (2383 aa)
	LOC109523558	MAP7 domain containing 1a. (722 aa)
	ebf3	EBF transcription factor 3a. (582 aa)
	ENSHCOP00000027476	CCAAT/enhancer-binding protein. (273 aa)

Your Current Organism:

Hippocampus comes

NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSHCOP00000003363	LOC109526528	ENSHCOP00000003363	ENSHCOP00000019412	COE1_DBD domain-containing protein.	IPT/TIG domain-containing protein.	0.590
ENSHCOP00000027476	LOC109518000	ENSHCOP00000027476	ENSHCOP00000007552	CCAAT/enhancer-binding protein.	Kruppel-like factor 5 like.	0.634
ENSHCOP00000027476	klf5	ENSHCOP00000027476	ENSHCOP00000014447	CCAAT/enhancer-binding protein.	Progesterone immunomodulatory binding factor 1.	0.634
HDAC3	LOC109530282	ENSHCOP00000003302	ENSHCOP00000010626	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Retinoid X receptor, alpha a.	0.493
HDAC3	ncor1	ENSHCOP00000003302	ENSHCOP00000022282	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Nuclear receptor corepressor 1.	0.962
HDAC3	ncor2	ENSHCOP00000003302	ENSHCOP00000010931	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Nuclear receptor corepressor 2.	0.962
LOC109518000	ENSHCOP00000027476	ENSHCOP00000007552	ENSHCOP00000027476	Kruppel-like factor 5 like.	CCAAT/enhancer-binding protein.	0.634
LOC109526528	ENSHCOP00000003363	ENSHCOP00000019412	ENSHCOP00000003363	IPT/TIG domain-containing protein.	COE1_DBD domain-containing protein.	0.590
LOC109530282	HDAC3	ENSHCOP00000010626	ENSHCOP00000003302	Retinoid X receptor, alpha a.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.493
LOC109530282	ncor1	ENSHCOP00000010626	ENSHCOP00000022282	Retinoid X receptor, alpha a.	Nuclear receptor corepressor 1.	0.797
LOC109530282	ncor2	ENSHCOP00000010626	ENSHCOP00000010931	Retinoid X receptor, alpha a.	Nuclear receptor corepressor 2.	0.797
MED26	med11	ENSHCOP00000015048	ENSHCOP00000018277	Mediator complex subunit 26.	Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.981
MED26	med18	ENSHCOP00000015048	ENSHCOP00000012561	Mediator complex subunit 26.	Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.998
MED26	med19	ENSHCOP00000015048	ENSHCOP00000007874	Mediator complex subunit 26.	Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.985
MED26	med21	ENSHCOP00000015048	ENSHCOP00000008283	Mediator complex subunit 26.	Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.984
MED26	med22	ENSHCOP00000015048	ENSHCOP00000008967	Mediator complex subunit 26.	Mediator complex subunit 22.	0.983
MED26	med29	ENSHCOP00000015048	ENSHCOP00000020299	Mediator complex subunit 26.	Mediator complex subunit 29.	0.982
MED26	med9	ENSHCOP00000015048	ENSHCOP00000019199	Mediator complex subunit 26.	Mediator of RNA polymerase II transcription subunit 9; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.981
klf5	ENSHCOP00000027476	ENSHCOP00000014447	ENSHCOP00000027476	Progesterone immunomodulatory binding factor 1.	CCAAT/enhancer-binding protein.	0.634
med11	MED26	ENSHCOP00000018277	ENSHCOP00000015048	Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Mediator complex subunit 26.	0.981