STRINGSTRING
LOC109520855 LOC109520855 apex1 apex1 rfc2 rfc2 lig1 lig1 pold1 pold1 rpa3 rpa3 pold2 pold2 LOC109509834 LOC109509834 ENSHCOP00000026411 ENSHCOP00000026411 ENSHCOP00000028059 ENSHCOP00000028059 pcna pcna FEN1 FEN1 pole3 pole3 rfc1 rfc1 meiob meiob pold4 pold4 pold3 pold3 LOC109517068 LOC109517068 pole2 pole2 rfc4 rfc4 LOC109509643 LOC109509643 LOC109520519 LOC109520519 rfc5 rfc5 Pole4 Pole4 RCBTB1 RCBTB1 LOC109526212 LOC109526212 rpa1 rpa1 ENSHCOP00000007515 ENSHCOP00000007515 LOC109512952 LOC109512952 polb polb rpa2 rpa2 LOC109527038 LOC109527038 pole pole rfc3 rfc3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC109520855Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (527 aa)
apex1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (311 aa)
rfc2Replication factor C (activator 1) 2. (244 aa)
lig1DNA ligase. (902 aa)
pold1DNA polymerase. (1105 aa)
rpa3Replication protein A3. (127 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (470 aa)
LOC109509834XPGI domain-containing protein. (306 aa)
ENSHCOP00000026411Uncharacterized protein. (408 aa)
ENSHCOP00000028059Uncharacterized protein. (127 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (371 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (148 aa)
rfc1Replication factor C subunit 1. (1130 aa)
meiobMethionine sulfoxide reductase B1b. (439 aa)
pold4Si:dkey-28b4.7. (106 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (437 aa)
LOC109517068Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (572 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (521 aa)
rfc4Replication factor C (activator 1) 4. (331 aa)
LOC109509643Endo/exonuclease/phosphatase domain-containing protein. (194 aa)
LOC109520519Zgc:110269. (317 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
Pole4CBFD_NFYB_HMF domain-containing protein. (128 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
LOC109526212Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (532 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (611 aa)
ENSHCOP00000007515Uncharacterized protein. (89 aa)
LOC109512952DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (525 aa)
polbDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (336 aa)
rpa2Replication protein A2. (314 aa)
LOC109527038ATPase family AAA domain containing 5a. (1619 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2282 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
Your Current Organism:
Hippocampus comes
NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse
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