STRINGSTRING
psmd3 psmd3 Pole4 Pole4 LOC109532275 LOC109532275 psmb3 psmb3 LOC109514590 LOC109514590 LOC109514645 LOC109514645 cdc27 cdc27 LOC109529845 LOC109529845 anapc1 anapc1 LOC109515783 LOC109515783 RCBTB1 RCBTB1 psmd5 psmd5 smc1a smc1a stag2 stag2 Cdca5 Cdca5 psmd10 psmd10 ENSHCOP00000019041 ENSHCOP00000019041 Rbbp8nl Rbbp8nl LOC109521384 LOC109521384 LOC109521383 LOC109521383 rb1 rb1 ube2e1 ube2e1 psmd13 psmd13 LOC109530441 LOC109530441 ENSHCOP00000020808 ENSHCOP00000020808 LOC109529021 LOC109529021 uba52 uba52 pole pole skp1 skp1 anapc4 anapc4 ENSHCOP00000021842 ENSHCOP00000021842 pola2 pola2 rfc3 rfc3 rad21 rad21 LOC109520855 LOC109520855 LOC109524773 LOC109524773 tm7sf3 tm7sf3 psmd1 psmd1 cdc25b cdc25b kxd1 kxd1 rfc2 rfc2 ENSHCOP00000023550 ENSHCOP00000023550 psmc2 psmc2 Pola1 Pola1 ENSHCOP00000023876 ENSHCOP00000023876 lig1 lig1 fam89a fam89a psmb7 psmb7 prim2 prim2 psmd6 psmd6 ENSHCOP00000024609 ENSHCOP00000024609 pold1 pold1 dna2 dna2 psmd9 psmd9 LOC109528119 LOC109528119 rpa3 rpa3 gins3 gins3 orc4 orc4 cdk7 cdk7 gins2 gins2 CCNE1 CCNE1 LOC109524515 LOC109524515 LOC109530167 LOC109530167 psmd7 psmd7 pold2 pold2 LOC109530879 LOC109530879 LOC109509834 LOC109509834 ENSHCOP00000026411 ENSHCOP00000026411 orc5 orc5 ENSHCOP00000026565 ENSHCOP00000026565 psmd8 psmd8 bicra bicra gins1 gins1 psma4 psma4 psmb4 psmb4 ENSHCOP00000027456 ENSHCOP00000027456 mcm4 mcm4 ENSHCOP00000027605 ENSHCOP00000027605 psmd14 psmd14 ENSHCOP00000028059 ENSHCOP00000028059 ube2s ube2s mcm8 mcm8 psma8 psma8 anapc7 anapc7 ENSHCOP00000004228 ENSHCOP00000004228 ENSHCOP00000004113 ENSHCOP00000004113 LOC109522206 LOC109522206 psme1 psme1 FEN1 FEN1 cdkn1b cdkn1b pcna pcna LOC109528635 LOC109528635 mcm3 mcm3 psmb2 psmb2 Anapc1 Anapc1 ENSHCOP00000002151 ENSHCOP00000002151 cdt1 cdt1 mnat1 mnat1 skp2 skp2 rfc1 rfc1 meiob meiob LOC109510167 LOC109510167 pds5a pds5a smc3 smc3 psmb9 psmb9 pold4 pold4 rpa1 rpa1 vps41 vps41 psma3 psma3 wee1 wee1 anapc16 anapc16 psmd2 psmd2 bicral bicral stag1 stag1 orc2 orc2 ube2c ube2c psmc3 psmc3 anapc15 anapc15 orc3 orc3 rbx1 rbx1 ENSHCOP00000011313 ENSHCOP00000011313 anapc11 anapc11 cdc16 cdc16 rfc4 rfc4 orc1 orc1 psmb1 psmb1 anapc10 anapc10 pole2 pole2 psme4 psme4 LOC109526229 LOC109526229 psmc6 psmc6 ESCO2 ESCO2 cul1 cul1 ENSHCOP00000009928 ENSHCOP00000009928 Anapc5 Anapc5 psmc4 psmc4 LOC109517068 LOC109517068 mcm6 mcm6 psmf1 psmf1 ubc ubc mcm2 mcm2 psme3 psme3 pold3 pold3 ENSHCOP00000008693 ENSHCOP00000008693 LOC109526212 LOC109526212 ccna2 ccna2 CABLES2 CABLES2 ENSHCOP00000007796 ENSHCOP00000007796 psma2 psma2 ubb ubb ENSHCOP00000007719 ENSHCOP00000007719 LOC109508904 LOC109508904 ENSHCOP00000007515 ENSHCOP00000007515 psma5 psma5 pds5b pds5b ENSHCOP00000007080 ENSHCOP00000007080 LOC109516890 LOC109516890 psme2 psme2 psmb6 psmb6 mcm7 mcm7 Stag3 Stag3 rpa2 rpa2 mcm9 mcm9 anapc2 anapc2 LOC109527038 LOC109527038 pole3 pole3 LOC109521072 LOC109521072 psmb5 psmb5 wapl wapl ccnh ccnh psma1 psma1 LOC109521328 LOC109521328 psmc5 psmc5 ENSHCOP00000014269 ENSHCOP00000014269 akt1 akt1 ENSHCOP00000015441 ENSHCOP00000015441 LOC109518579 LOC109518579 prim1 prim1 cdk2 cdk2 Mcm5 Mcm5 LOC109518507 LOC109518507 psmd12 psmd12 psmc1 psmc1 rps27a rps27a cdk4 cdk4 psma6 psma6 LOC109520519 LOC109520519 rfc5 rfc5 FZR1 FZR1 cdc23 cdc23 cdc26 cdc26 cdc6 cdc6 gins4-2 gins4-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psmd3Proteasome 26S subunit, non-ATPase 3. (520 aa)
Pole4CBFD_NFYB_HMF domain-containing protein. (128 aa)
LOC109532275SCY domain-containing protein. (126 aa)
psmb3Proteasome subunit beta. (205 aa)
LOC109514590Proteasome 26S subunit, non-ATPase 4a. (373 aa)
LOC109514645Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (77 aa)
cdc27Cell division cycle 27. (803 aa)
LOC109529845Cyclin-dependent kinase inhibitor 1Cb. (202 aa)
anapc1Anaphase promoting complex subunit 1. (1677 aa)
LOC109515783Wee1-like protein kinase. (504 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (504 aa)
smc1aStructural maintenance of chromosomes protein. (1231 aa)
stag2Stromal antigen 2b. (1273 aa)
Cdca5Uncharacterized protein. (256 aa)
psmd10Proteasome 26S subunit, non-ATPase 10. (226 aa)
ENSHCOP00000019041Uncharacterized protein. (140 aa)
Rbbp8nlRetinoblastoma binding protein 8-like. (434 aa)
LOC109521384Fizzy/cell division cycle 20 related 1b. (481 aa)
LOC109521383Fizzy/cell division cycle 20 related 1b. (481 aa)
rb1Retinoblastoma 1. (903 aa)
ube2e1UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (194 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (378 aa)
LOC109530441Wee1-like protein kinase. (557 aa)
ENSHCOP00000020808SCD domain-containing protein. (119 aa)
LOC109529021VWFA domain-containing protein. (374 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2282 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
anapc4Anaphase promoting complex subunit 4. (758 aa)
ENSHCOP00000021842Rad21_Rec8 domain-containing protein. (76 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (600 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
rad21RAD21 cohesin complex component a. (639 aa)
LOC109520855Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (527 aa)
LOC109524773PCI domain-containing protein. (389 aa)
tm7sf3Transmembrane 7 superfamily member 3. (549 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (959 aa)
cdc25bRhodanese domain-containing protein. (583 aa)
kxd1KxDL motif containing 1. (185 aa)
rfc2Replication factor C (activator 1) 2. (244 aa)
ENSHCOP00000023550Proteasome subunit beta. (281 aa)
psmc2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
Pola1DNA polymerase. (1356 aa)
ENSHCOP00000023876Uncharacterized protein. (282 aa)
lig1DNA ligase. (902 aa)
fam89aFamily with sequence similarity 89 member A. (177 aa)
psmb7Proteasome subunit beta. (277 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (519 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (389 aa)
ENSHCOP00000024609SCD domain-containing protein. (121 aa)
pold1DNA polymerase. (1105 aa)
dna2DNA replication helicase/nuclease 2. (1305 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (210 aa)
LOC109528119CYCLIN domain-containing protein; Belongs to the cyclin family. (267 aa)
rpa3Replication protein A3. (127 aa)
gins3GINS complex subunit 3. (211 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
cdk7Cyclin-dependent kinase 7. (298 aa)
gins2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (431 aa)
LOC109524515Cyclin E1; Belongs to the cyclin family. (360 aa)
LOC109530167Proteasome 26S subunit, non-ATPase 11b. (422 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (326 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (470 aa)
LOC109530879Structural maintenance of chromosomes protein. (1251 aa)
LOC109509834XPGI domain-containing protein. (306 aa)
ENSHCOP00000026411Uncharacterized protein. (408 aa)
orc5Origin recognition complex, subunit 5. (452 aa)
ENSHCOP00000026565DUF3437 domain-containing protein. (297 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (265 aa)
bicraBRD4 interacting chromatin remodeling complex associated protein. (1764 aa)
gins1GINS complex subunit 1 (Psf1 homolog). (196 aa)
psma4Proteasome subunit alpha type. (261 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
ENSHCOP00000027456DNA helicase; Belongs to the MCM family. (702 aa)
mcm4DNA helicase; Belongs to the MCM family. (939 aa)
ENSHCOP00000027605Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (310 aa)
ENSHCOP00000028059Uncharacterized protein. (127 aa)
ube2sUbiquitin-conjugating enzyme E2S; Belongs to the ubiquitin-conjugating enzyme family. (217 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (828 aa)
psma8Proteasome subunit alpha type. (251 aa)
anapc7Anaphase promoting complex subunit 7. (565 aa)
ENSHCOP00000004228Uncharacterized protein. (76 aa)
ENSHCOP00000004113Cyclin E2; Belongs to the cyclin family. (281 aa)
LOC109522206Cyclin-dependent kinase inhibitor 1A. (165 aa)
psme1Proteasome activator subunit 1. (249 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (371 aa)
cdkn1bCyclin-dependent kinase inhibitor 1Bb. (179 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
LOC109528635Tyrosine-protein kinase. (509 aa)
mcm3DNA helicase; Belongs to the MCM family. (816 aa)
psmb2Proteasome subunit beta. (202 aa)
Anapc1Uncharacterized protein. (149 aa)
ENSHCOP00000002151Uncharacterized protein. (84 aa)
cdt1Chromatin licensing and DNA replication factor 1. (617 aa)
mnat1MNAT1 component of CDK activating kinase. (289 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (425 aa)
rfc1Replication factor C subunit 1. (1130 aa)
meiobMethionine sulfoxide reductase B1b. (439 aa)
LOC109510167Non-specific serine/threonine protein kinase. (480 aa)
pds5aPDS5 cohesin associated factor A. (1213 aa)
smc3Structural maintenance of chromosomes protein. (1216 aa)
psmb9Proteasome subunit beta. (211 aa)
pold4Si:dkey-28b4.7. (106 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (611 aa)
vps41zf-C2H2_3 domain-containing protein. (2951 aa)
psma3Proteasome subunit alpha type. (255 aa)
wee1WEE1 G2 checkpoint kinase. (425 aa)
anapc16Anaphase promoting complex subunit 16. (83 aa)
psmd226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (905 aa)
bicralBRD4 interacting chromatin remodeling complex associated protein like. (698 aa)
stag1Stromal antigen 1a. (1202 aa)
orc2Origin recognition complex, subunit 2. (576 aa)
ube2cUbiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (189 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (427 aa)
anapc15Anaphase promoting complex subunit 15. (123 aa)
orc3Origin recognition complex, subunit 3. (684 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (181 aa)
ENSHCOP00000011313STAG domain-containing protein. (182 aa)
anapc11APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (523 aa)
rfc4Replication factor C (activator 1) 4. (331 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (878 aa)
psmb1Proteasome subunit beta. (237 aa)
anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (186 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (521 aa)
psme4Proteasome activator subunit 4a. (1777 aa)
LOC109526229Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (483 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (614 aa)
cul1Cullin 1b; Belongs to the cullin family. (776 aa)
ENSHCOP00000009928Anaphase promoting complex subunit 5. (327 aa)
Anapc5Anaphase promoting complex subunit 5. (425 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
LOC109517068Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (572 aa)
mcm6DNA helicase; Belongs to the MCM family. (853 aa)
psmf1Proteasome inhibitor subunit 1. (273 aa)
ubcUncharacterized protein. (989 aa)
mcm2Minichromosome maintenance complex component 2; Belongs to the MCM family. (759 aa)
psme3Proteasome activator subunit 3. (263 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (437 aa)
ENSHCOP00000008693Uncharacterized protein. (270 aa)
LOC109526212Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (532 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (394 aa)
CABLES2Cdk5 and Abl enzyme substrate 2. (413 aa)
ENSHCOP00000007796V-akt murine thymoma viral oncogene homolog 3b; Belongs to the protein kinase superfamily. (393 aa)
psma2Proteasome subunit alpha type. (234 aa)
ubbUbiquitin B. (281 aa)
ENSHCOP00000007719Ubiquitin-like domain-containing protein. (106 aa)
LOC109508904Uncharacterized protein. (146 aa)
ENSHCOP00000007515Uncharacterized protein. (89 aa)
psma5Proteasome subunit alpha type. (233 aa)
pds5bPDS5 cohesin associated factor B. (1409 aa)
ENSHCOP00000007080Rad21_Rec8_N domain-containing protein. (143 aa)
LOC109516890WD_REPEATS_REGION domain-containing protein. (488 aa)
psme2Proteasome activator subunit 2. (240 aa)
psmb6Proteasome subunit beta. (233 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (724 aa)
Stag3Uncharacterized protein. (293 aa)
rpa2Replication protein A2. (314 aa)
mcm9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1028 aa)
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (745 aa)
LOC109527038ATPase family AAA domain containing 5a. (1619 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (148 aa)
LOC109521072Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family. (202 aa)
psmb5Proteasome subunit beta. (272 aa)
waplWAPL cohesin release factor a. (1146 aa)
ccnhCyclin H; Belongs to the cyclin family. (320 aa)
psma1Proteasome subunit alpha type. (264 aa)
LOC109521328Cdk5 and Abl enzyme substrate 1. (545 aa)
psmc5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
ENSHCOP00000014269BLM10_mid domain-containing protein. (573 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (395 aa)
ENSHCOP00000015441Uncharacterized protein. (167 aa)
LOC109518579WAPL cohesin release factor b. (1173 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (429 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
Mcm5Uncharacterized protein. (57 aa)
LOC109518507Geminin DNA replication inhibitor. (224 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (456 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
rps27aRibosomal protein S27a. (156 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (304 aa)
psma6Proteasome subunit alpha type. (246 aa)
LOC109520519Zgc:110269. (317 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
FZR1Fizzy/cell division cycle 20 related 1a. (495 aa)
cdc23CDC23 (cell division cycle 23, yeast, homolog). (580 aa)
cdc26Cell division cycle 26 homolog. (95 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (545 aa)
gins4-2DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa)
Your Current Organism:
Hippocampus comes
NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse
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