STRINGSTRING
ung ung ogg1 ogg1 polb polb Mpg Mpg rfc1 rfc1 meiob meiob pold4 pold4 rpa1 rpa1 rec114 rec114 rpa2 rpa2 LOC109527038 LOC109527038 pole3 pole3 Mbd4 Mbd4 xrcc1 xrcc1 LOC109522167 LOC109522167 FEN1 FEN1 pcna pcna LOC109522412 LOC109522412 ENSHCOP00000019923 ENSHCOP00000019923 RCBTB1 RCBTB1 LOC109509910 LOC109509910 Pole4 Pole4 rfc5 rfc5 ENSHCOP00000017279 ENSHCOP00000017279 smug1 smug1 LOC109520519 LOC109520519 LOC109523961 LOC109523961 LOC109509643 LOC109509643 LOC109530839 LOC109530839 neil1 neil1 rfc4 rfc4 pole2 pole2 LOC109517068 LOC109517068 parp2 parp2 ENSHCOP00000028059 ENSHCOP00000028059 nthl1 nthl1 LOC109530840 LOC109530840 ENSHCOP00000026411 ENSHCOP00000026411 LOC109509834 LOC109509834 pold2 pold2 rpa3 rpa3 pold1 pold1 pnkp pnkp lig1 lig1 rfc2 rfc2 parp1 parp1 pold3 pold3 LOC109526212 LOC109526212 LOC109512952 LOC109512952 ENSHCOP00000008016 ENSHCOP00000008016 lig3 lig3 adprhl2 adprhl2 ENSHCOP00000007515 ENSHCOP00000007515 MUTYH MUTYH apex1 apex1 LOC109520855 LOC109520855 rfc3 rfc3 pole pole
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ungUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (296 aa)
ogg18-oxoguanine DNA glycosylase. (413 aa)
polbDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (336 aa)
MpgN-methylpurine DNA glycosylase. (242 aa)
rfc1Replication factor C subunit 1. (1130 aa)
meiobMethionine sulfoxide reductase B1b. (439 aa)
pold4Si:dkey-28b4.7. (106 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (611 aa)
rec114REC114 meiotic recombination protein. (226 aa)
rpa2Replication protein A2. (314 aa)
LOC109527038ATPase family AAA domain containing 5a. (1619 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (148 aa)
Mbd4Methyl-CpG binding domain protein 4. (113 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (612 aa)
LOC109522167Poly [ADP-ribose] polymerase. (524 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (371 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
LOC109522412Poly [ADP-ribose] polymerase. (528 aa)
ENSHCOP00000019923Si:cabz01080528.1. (630 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
LOC109509910Poly (ADP-ribose) glycohydrolase a. (738 aa)
Pole4CBFD_NFYB_HMF domain-containing protein. (128 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
ENSHCOP00000017279Von Willebrand factor A domain containing 5B2. (817 aa)
smug1Single-strand-selective monofunctional uracil-DNA glycosylase 1. (289 aa)
LOC109520519Zgc:110269. (317 aa)
LOC109523961Uncharacterized protein. (656 aa)
LOC109509643Endo/exonuclease/phosphatase domain-containing protein. (194 aa)
LOC109530839Thymine DNA glycosylase, tandem duplicate 1. (383 aa)
neil1Nei-like DNA glycosylase 1. (362 aa)
rfc4Replication factor C (activator 1) 4. (331 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (521 aa)
LOC109517068Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (572 aa)
parp2Poly [ADP-ribose] polymerase. (661 aa)
ENSHCOP00000028059Uncharacterized protein. (127 aa)
nthl1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (405 aa)
LOC109530840Thymine DNA glycosylase, tandem duplicate 2. (446 aa)
ENSHCOP00000026411Uncharacterized protein. (408 aa)
LOC109509834XPGI domain-containing protein. (306 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (470 aa)
rpa3Replication protein A3. (127 aa)
pold1DNA polymerase. (1105 aa)
pnkpPolynucleotide kinase 3'-phosphatase. (609 aa)
lig1DNA ligase. (902 aa)
rfc2Replication factor C (activator 1) 2. (244 aa)
parp1Poly [ADP-ribose] polymerase. (1020 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (437 aa)
LOC109526212Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (532 aa)
LOC109512952DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (525 aa)
ENSHCOP00000008016Uncharacterized protein. (88 aa)
lig3DNA ligase. (993 aa)
adprhl2ADP-ribosylhydrolase like 2. (380 aa)
ENSHCOP00000007515Uncharacterized protein. (89 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (526 aa)
apex1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (311 aa)
LOC109520855Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (527 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2282 aa)
Your Current Organism:
Hippocampus comes
NCBI taxonomy Id: 109280
Other names: H. comes, tiger tail seahorse
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