STRINGSTRING
KQS_00460 KQS_00460 ahcY ahcY metK metK metY metY metX metX thrA thrA metZ metZ KQS_02445 KQS_02445 KQS_02455 KQS_02455 metF metF pssA pssA vdh vdh KQS_04150 KQS_04150 KQS_05795 KQS_05795 ilvE ilvE ilvD ilvD ilvB ilvB ilvH ilvH ilvC ilvC ilvA ilvA KQS_05855 KQS_05855 KQS_05860 KQS_05860 KQS_06180 KQS_06180 KQS_07125 KQS_07125 sdaA sdaA serC serC serA serA psd psd KQS_10835 KQS_10835 KQS_10900 KQS_10900 KQS_11355 KQS_11355 KQS_12695 KQS_12695
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KQS_00460Cys/Met metabolism PLP-dependent enzyme. (381 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (438 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (416 aa)
metYProbable O-acetylhomoserine aminocarboxypropyltransferase. (430 aa)
metXHomoserine O-acetyltransferase. (325 aa)
thrABifunctional enzyme : aspartate kinase/homoserine dehydrogenase. (802 aa)
metZCys/Met metabolism PLP-dependent enzyme; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (391 aa)
KQS_02445Methionine synthase, homocysteine S-methyltransferase domain. (339 aa)
KQS_02455Methionine synthase, 5-methyltetrahydrofolate--homocysteine methyltransferase domain; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (902 aa)
metFMethylenetetrahydrofolate reductase (NAD(P)H); Belongs to the methylenetetrahydrofolate reductase family. (318 aa)
pssACDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (247 aa)
vdhValine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (368 aa)
KQS_04150Cys/Met metabolism PLP-dependent enzyme. (400 aa)
KQS_05795Protein of unknown function. (489 aa)
ilvEBranched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (295 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (557 aa)
ilvBAcetolactate synthase, large subunit. (583 aa)
ilvHAcetolactate synthase, small subunit. (195 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (347 aa)
ilvAThreonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (397 aa)
KQS_05855Hypothetical protein. (54 aa)
KQS_05860Protein of unknown function. (230 aa)
KQS_06180Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase family protein; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (354 aa)
KQS_07125Probable phosphoserine phosphatase. (407 aa)
sdaAL-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (471 aa)
serCPhosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (358 aa)
serAPhosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (317 aa)
psdPhosphatidylserine decarboxylase. (221 aa)
KQS_10835Cysteine synthase/cystathionine beta-synthase family protein. (453 aa)
KQS_10900Cysteine synthase/cystathionine beta-synthase family protein. (346 aa)
KQS_11355Protein of unknown function. (150 aa)
KQS_12695Putative phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa)
Your Current Organism:
Flavobacterium indicum
NCBI taxonomy Id: 1094466
Other names: F. indicum GPTSA100-9 = DSM 17447, Flavobacterium indicum CIP 109464, Flavobacterium indicum DSM 17447, Flavobacterium indicum DSM 17447 = GPTSA100-9, Flavobacterium indicum GPTSA100-9, Flavobacterium indicum GPTSA100-9 = DSM 17447, Flavobacterium sp. GPTSA100-9
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