STRINGSTRING
Tsac_0028 Tsac_0028 Tsac_0029 Tsac_0029 Tsac_0046 Tsac_0046 Tsac_0047 Tsac_0047 ldh ldh Tsac_0331 Tsac_0331 Tsac_0380 Tsac_0380 Tsac_0381 Tsac_0381 Tsac_0488 Tsac_0488 Tsac_0563 Tsac_0563 ilvC ilvC Tsac_0565 Tsac_0565 leuC leuC leuD leuD leuB leuB ilvD ilvD Tsac_0570 Tsac_0570 Tsac_0915 Tsac_0915 Tsac_1063 Tsac_1063 Tsac_1064 Tsac_1064 Tsac_1065 Tsac_1065 Tsac_1066 Tsac_1066 Tsac_1067 Tsac_1067 Tsac_1885 Tsac_1885 ilvE ilvE Tsac_2160 Tsac_2160 Tsac_2161 Tsac_2161 Tsac_2162 Tsac_2162 Tsac_2163 Tsac_2163 Tsac_2164 Tsac_2164 pckA pckA Tsac_2172 Tsac_2172 Tsac_2177 Tsac_2177 Tsac_2178 Tsac_2178 Tsac_2179 Tsac_2179 Tsac_2180 Tsac_2180 Tsac_2182 Tsac_2182 Tsac_2529 Tsac_2529
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Tsac_0028KEGG: txy:Thexy_1925 aconitate hydratase; TIGRFAM: Aconitase, putative; 3-isopropylmalate dehydratase, small subunit, subgroup; PFAM: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Aconitase A/isopropylmalate dehydratase small subunit, swivel. (640 aa)
Tsac_0029KEGG: txy:Thexy_1926 homocitrate synthase; TIGRFAM: Homocitrate synthase NifV-type; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (383 aa)
Tsac_0046KEGG: txy:Thexy_1943 pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (1175 aa)
Tsac_0047KEGG: txy:Thexy_1944 isocitrate dehydrogenase, NADP-dependent; TIGRFAM: Isocitrate dehydrogenase NADP-dependent, eukaryotic; PFAM: Isocitrate/isopropylmalate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (403 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (311 aa)
Tsac_0331PFAM: Thiamine biosynthesis Thi4 protein; KEGG: txy:Thexy_2207 thiamine biosynthesis Thi4 protein. (637 aa)
Tsac_0380KEGG: txy:Thexy_2267 2-oxoacid:acceptor oxidoreductase, alpha subunit; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase. (562 aa)
Tsac_0381KEGG: txy:Thexy_2268 pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (282 aa)
Tsac_0488PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; KEGG: cbh:CLC_0304 malic enzyme. (390 aa)
Tsac_0563KEGG: txy:Thexy_0012 acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. (161 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa)
Tsac_0565PFAM: Pyruvate carboxyltransferase; KEGG: txy:Thexy_0014 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (397 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (418 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (355 aa)
ilvDTIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: txy:Thexy_0018 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (554 aa)
Tsac_0570KEGG: txy:Thexy_0019 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, central region; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (551 aa)
Tsac_0915KEGG: txy:Thexy_0241 pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: Pyruvate-flavodoxin oxidoreductase; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase; Pyruvate-flavodoxin oxidoreductase, EKR domain; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; Thiamine pyrophosphate enzyme, C-terminal TPP-binding. (1172 aa)
Tsac_1063KEGG: txy:Thexy_0386 hypothetical protein. (224 aa)
Tsac_1064PFAM: 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; KEGG: txy:Thexy_1632 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (76 aa)
Tsac_1065PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Transketolase, C-terminal; KEGG: txy:Thexy_1631 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin). (354 aa)
Tsac_1066PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; KEGG: txy:Thexy_1630 2-oxoglutarate synthase. (249 aa)
Tsac_1067PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: txy:Thexy_0390 pyruvate/ketoisovalerate oxidoreductase, gamma subunit. (186 aa)
Tsac_1885PFAM: Conserved carboxylase region; Pyruvate carboxyltransferase; KEGG: txy:Thexy_1228 Pyruvate carboxylase. (464 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (290 aa)
Tsac_2160PFAM: Pyruvate/ketoisovalerate oxidoreductase; KEGG: txy:Thexy_1615 pyruvate/ketoisovalerate oxidoreductase, gamma subunit. (182 aa)
Tsac_2161PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; KEGG: txy:Thexy_1616 2-oxoglutarate synthase. (276 aa)
Tsac_2162PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; KEGG: txy:Thexy_1617 2-oxoglutarate synthase. (373 aa)
Tsac_2163PFAM: 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; KEGG: txy:Thexy_1618 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (73 aa)
Tsac_2164Sodium ion-translocating decarboxylase, beta subunit; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD). (374 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (543 aa)
Tsac_2172PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region; KEGG: txy:Thexy_1625 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (416 aa)
Tsac_2177KEGG: txy:Thexy_1629 pyruvate/ketoisovalerate oxidoreductase, gamma subunit; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate; PFAM: Pyruvate/ketoisovalerate oxidoreductase. (183 aa)
Tsac_2178PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; KEGG: txy:Thexy_1630 2-oxoglutarate synthase. (249 aa)
Tsac_2179PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Transketolase, C-terminal; KEGG: txy:Thexy_1631 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin). (354 aa)
Tsac_2180PFAM: 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; KEGG: txy:Thexy_1632 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (76 aa)
Tsac_2182PFAM: Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region; Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal; KEGG: txy:Thexy_1634 leucine dehydrogenase. (356 aa)
Tsac_2529KEGG: txy:Thexy_0776 2-isopropylmalate synthase/homocitrate synthase family protein; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase related; PFAM: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (519 aa)
Your Current Organism:
Thermoanaerobacterium saccharolyticum
NCBI taxonomy Id: 1094508
Other names: T. saccharolyticum JW/SL-YS485, Thermoanaerobacterium saccharolyticum JW/SL-YS485, Thermoanaerobacterium saccharolyticum str. JW/SL-YS485, Thermoanaerobacterium saccharolyticum strain JW/SL-YS485, Thermoanaerobacterium sp. (strain JW/SL YS485)
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