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| | metK | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (396 aa) |
| | Tsac_0035 | KEGG: txy:Thexy_1932 pyrimidine-nucleoside phosphorylase; TIGRFAM: Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic; PFAM: Glycosyl transferase, family 3; Glycosyl transferase, family 3, N-terminal; Pyrimidine nucleoside phosphorylase, C-terminal. (431 aa) |
| | Tsac_0037 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (131 aa) |
| | Tsac_0043 | Formiminotransferase-cyclodeaminase; PFAM: Cyclodeaminase/cyclohydrolase; KEGG: txy:Thexy_1940 methenyltetrahydrofolate cyclohydrolase. (211 aa) |
| | Tsac_0044 | KEGG: txy:Thexy_1941 glutamate formiminotransferase; TIGRFAM: Formiminotransferase; PFAM: Formiminotransferase, N-terminal; Formiminotransferase, C-terminal. (298 aa) |
| | Tsac_0104 | 5'-Nucleotidase domain-containing protein; KEGG: txy:Thexy_1993 5'-nucleotidase., 2',3'-cyclic-nucleotide 2'-phosphodiesterase; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; SH3, type 3; SMART: Bacterial SH3-like region. (1208 aa) |
| | Tsac_0235 | KEGG: txy:Thexy_2110 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; PFAM: DAHP synthetase I/KDSA. (335 aa) |
| | Tsac_0313 | KEGG: txy:Thexy_2189 UDP-N-acetylglucosamine 2-epimerase; TIGRFAM: UDP-N-acetylglucosamine 2-epimerase; PFAM: UDP-N-acetylglucosamine 2-epimerase. (383 aa) |
| | Tsac_0314 | PFAM: Glycosyl transferase, family 4, conserved region; KEGG: txy:Thexy_2190 glycosyl transferase family 4. (344 aa) |
| | Tsac_0315 | PFAM: CMP/dCMP deaminase, zinc-binding; KEGG: txy:Thexy_2191 CMP/dCMP deaminase zinc-binding protein. (148 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (210 aa) |
| | Tsac_0318 | KEGG: txy:Thexy_2194 protein tyrosine phosphatase; PFAM: Protein-tyrosine phosphatase, low molecular weight; SMART: Protein-tyrosine phosphatase, low molecular weight. (146 aa) |
| | Tsac_0319 | Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (349 aa) |
| | Tsac_0320 | PFAM: Zinc/iron permease; KEGG: txy:Thexy_2196 zinc/iron permease. (239 aa) |
| | prfA | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (353 aa) |
| | prmC | protein-(glutamine-N5) methyltransferase, release factor-specific; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (279 aa) |
| | Tsac_0323 | PFAM: Protein of unknown function DUF1385; KEGG: txy:Thexy_2199 hypothetical protein. (309 aa) |
| | tdk | KEGG: txy:Thexy_2200 thymidine kinase; HAMAP: Thymidine kinase, subgroup; PFAM: Thymidine kinase. (192 aa) |
| | Tsac_0367 | KEGG: txy:Thexy_2251 histidinol phosphate phosphatase HisJ family; TIGRFAM: Histidinol phosphate phosphatase, HisJ; PFAM: PHP, C-terminal; Belongs to the PHP hydrolase family. HisK subfamily. (272 aa) |
| | Tsac_0370 | KEGG: txy:Thexy_2256 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; Amino acid-binding ACT. (533 aa) |
| | Tsac_0371 | PFAM: Aminotransferase, class V/Cysteine desulfurase; KEGG: txy:Thexy_2257 serine--pyruvate transaminase. (361 aa) |
| | Tsac_0372 | KEGG: txy:Thexy_2258 glycerate kinase; TIGRFAM: Glycerate kinase; PFAM: Glycerate kinase; Belongs to the glycerate kinase type-1 family. (372 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (301 aa) |
| | Tsac_0375 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (351 aa) |
| | Tsac_0376 | PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; KEGG: txy:Thexy_2263 homoserine dehydrogenase. (419 aa) |
| | Tsac_0377 | UPF0735 ACT domain-containing protein; KEGG: txy:Thexy_2264 hypothetical protein; HAMAP: Ligand-binding-predicted, ACT; PFAM: Amino acid-binding ACT; Belongs to the UPF0735 family. (146 aa) |
| | Tsac_0378 | KEGG: txy:Thexy_2265 hypothetical protein. (305 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa) |
| | Tsac_0571 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (360 aa) |
| | Tsac_0572 | KEGG: txy:Thexy_0021 riboflavin synthase, alpha subunit; TIGRFAM: Lumazine-binding protein; PFAM: Lumazine-binding protein. (206 aa) |
| | ribBA | GTP cyclohydrolase-2; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (396 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (156 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (205 aa) |
| | arcA | PFAM: Amidinotransferase; KEGG: txy:Thexy_0082 arginine deiminase. (406 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (303 aa) |
| | argR | Arginine repressor, ArgR; Regulates arginine biosynthesis genes. (162 aa) |
| | Tsac_0766 | PFAM: Amino acid permease-associated region; KEGG: txy:Thexy_0172 amino acid permease-associated region. (458 aa) |
| | arcA-2 | TIGRFAM: Arginine deiminase; HAMAP: Arginine deiminase; KEGG: txy:Thexy_0173 arginine deiminase; PFAM: Amidinotransferase. (415 aa) |
| | Tsac_0768 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (329 aa) |
| | Tsac_0769 | KEGG: txy:Thexy_0175 arginine/ornithine antiporter; TIGRFAM: Arginine/ornithine antiporter; PFAM: Amino acid permease-associated region. (475 aa) |
| | Tsac_0770 | KEGG: txy:Thexy_0176 carbamate kinase; TIGRFAM: Bacterial carbamate kinase; PFAM: Aspartate/glutamate/uridylate kinase. (329 aa) |
| | argR-2 | Arginine repressor, ArgR; Regulates arginine biosynthesis genes. (149 aa) |
| | Tsac_0773 | PFAM: Protein of unknown function DUF1934; KEGG: txy:Thexy_0179 hypothetical protein. (140 aa) |
| | argS | TIGRFAM: Arginyl-tRNA synthetase, class Ic; HAMAP: Arginyl-tRNA synthetase, class Ic; KEGG: txy:Thexy_0180 arginyl-tRNA synthetase. (562 aa) |
| | Tsac_0775 | KEGG: txy:Thexy_0181 Zn-dependent hydrolase of the beta-lactamase fold-like protein protein. (213 aa) |
| | Tsac_0783 | PFAM: Aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: txy:Thexy_0185 Threonine aldolase. (345 aa) |
| | Tsac_0801 | KEGG: txy:Thexy_0201 hypothetical protein. (166 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa) |
| | argJ | N-acetylglutamate synthase (N-acetylornithine aminotransferase); Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (406 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (299 aa) |
| | argD | TIGRFAM: Acetylornithine/succinylornithine aminotransferase; HAMAP: Acetylornithine/succinyldiaminopimelate aminotransferase; KEGG: txy:Thexy_0205 acetylornithine/succinyldiaminopimelate aminotransferase; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (394 aa) |
| | carA | KEGG: txy:Thexy_0206 carbamoyl-phosphate synthase, small subunit; TIGRFAM: Carbamoyl phosphate synthase, small subunit; PFAM: Carbamoyl phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; Belongs to the CarA family. (356 aa) |
| | carB | KEGG: txy:Thexy_0207 carbamoyl-phosphate synthase, large subunit; TIGRFAM: Carbamoyl phosphate synthase, large subunit, glutamine-dependent; PFAM: Carbamoyl phosphate synthetase, large subunit, ATP-binding; Carbamoyl phosphate synthase, large subunit, N-terminal; Carbamoyl phosphate synthetase, large subunit, oligomerisation; MGS-like. (1073 aa) |
| | argG | TIGRFAM: Argininosuccinate synthase; HAMAP: Argininosuccinate synthase; KEGG: txy:Thexy_0208 argininosuccinate synthase; PFAM: Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (412 aa) |
| | argH | TIGRFAM: Argininosuccinate lyase; HAMAP: Argininosuccinate lyase; KEGG: txy:Thexy_0209 argininosuccinate lyase; PFAM: Fumarate lyase. (440 aa) |
| | Tsac_0909 | KEGG: txy:Thexy_0237 uracil-xanthine permease; TIGRFAM: Xanthine/uracil permease; PFAM: Xanthine/uracil/vitamin C permease. (425 aa) |
| | fhs | KEGG: txy:Thexy_0263 Formate--tetrahydrofolate ligase; HAMAP: Formate-tetrahydrofolate ligase, FTHFS; PFAM: Formate-tetrahydrofolate ligase, FTHFS. (555 aa) |
| | Tsac_0942 | KEGG: txy:Thexy_0264 hypothetical protein. (121 aa) |
| | folE | TIGRFAM: GTP cyclohydrolase I; HAMAP: GTP cyclohydrolase I; KEGG: txy:Thexy_0279 GTP cyclohydrolase 1; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase. (188 aa) |
| | Tsac_0958 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (270 aa) |
| | Tsac_0959 | KEGG: txy:Thexy_0281 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; PFAM: 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. (165 aa) |
| | Tsac_0960 | KEGG: txy:Thexy_0282 queuosine biosynthesis protein QueD; TIGRFAM: queuosine biosynthesis protein QueD; PFAM: 6-pyruvoyl tetrahydropterin synthase-related. (123 aa) |
| | sfsA | TIGRFAM: Sugar fermentation stimulation protein; HAMAP: Sugar fermentation stimulation protein; KEGG: txy:Thexy_0283 Sugar fermentation stimulation protein A; PFAM: Sugar fermentation stimulation protein; Belongs to the SfsA family. (229 aa) |
| | Tsac_0962 | UPF0291 protein; KEGG: txy:Thexy_0284 hypothetical protein; HAMAP: UPF0291 protein; PFAM: Protein of unknown function DUF896, bacterial. (71 aa) |
| | Tsac_0966 | Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1141 aa) |
| | Tsac_1119 | PFAM: Nucleoside phosphorylase; KEGG: cpo:COPRO5265_1476 uridine phosphorylase (UrdPase) (UPase). (246 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (386 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (427 aa) |
| | hisC | TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: txy:Thexy_0447 histidinol-phosphate aminotransferase; PFAM: Aminotransferase, class I/II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (351 aa) |
| | hisB | KEGG: txy:Thexy_0448 imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (200 aa) |
| | hisA | TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; HAMAP: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: txy:Thexy_0450 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis. (235 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (254 aa) |
| | hisI | TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Histidine biosynthesis bifunctional protein hisIE; KEGG: txy:Thexy_0452 phosphoribosyl-ATP pyrophosphatase; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (226 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (410 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (445 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (305 aa) |
| | Tsac_1320 | KEGG: txy:Thexy_0603 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme. (430 aa) |
| | Tsac_1396 | PFAM: Methylenetetrahydrofolate reductase; KEGG: txy:Thexy_1843 methylenetetrahydrofolate reductase. (300 aa) |
| | Tsac_1397 | PFAM: Homocysteine S-methyltransferase; Dihydropteroate synthase, DHPS; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding; KEGG: txy:Thexy_1842 methionine synthase. (801 aa) |
| | Tsac_1498 | KEGG: txy:Thexy_1682 FolC bifunctional protein; TIGRFAM: Folylpolyglutamate synthetase; PFAM: Mur ligase, C-terminal; Mur ligase, central; Belongs to the folylpolyglutamate synthase family. (425 aa) |
| | dapH | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (237 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (251 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (327 aa) |
| | Tsac_1532 | Isoaspartyl dipeptidase; Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. Belongs to the peptidase M38 family. (389 aa) |
| | ychF | GTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (363 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (356 aa) |
| | Tsac_1618 | KEGG: txy:Thexy_1111 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; PFAM: DAHP synthetase I/KDSA. (338 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (423 aa) |
| | Tsac_1639 | KEGG: txy:Thexy_1132 phosphoribosylformylglycinamidine synthase; TIGRFAM: Phosphoribosylformylglycinamidine synthase, FGAM; PFAM: AIR synthase related protein, C-terminal. (1255 aa) |
| | Tsac_1660 | PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; KEGG: sgy:Sgly_0513 cysteine synthase. (408 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (173 aa) |
| | pyrR | Bifunctional protein pyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (177 aa) |
| | pyrB | TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; HAMAP: Aspartate carbamoyltransferase; KEGG: txy:Thexy_1411 aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa) |
| | pyrC | Dihydroorotase, multifunctional complex type protein; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (431 aa) |
| | pyrF | TIGRFAM: Orotidine 5'-phosphate decarboxylase, subfamily 2, core; HAMAP: Orotidine 5'-phosphate decarboxylase; KEGG: txy:Thexy_1409 Orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase, core; Belongs to the OMP decarboxylase family. Type 2 subfamily. (306 aa) |
| | pyrK | Dihydroorotate dehydrogenase, electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (243 aa) |
| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (301 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (191 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (277 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (150 aa) |
| | Tsac_1839 | KEGG: txy:Thexy_1274 aspartate kinase; TIGRFAM: Aspartate kinase region; PFAM: Aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (412 aa) |
| | Tsac_1858 | KEGG: txy:Thexy_1255 adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; PFAM: Adenylosuccinate lyase, C-terminal; Fumarate lyase. (474 aa) |
| | surE | Survival protein SurE-like phosphatase/nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (250 aa) |
| | folD | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (283 aa) |
| | Tsac_2008 | PFAM: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; KEGG: txy:Thexy_1466 Peroxiredoxin. (154 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (274 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (391 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: txy:Thexy_1469 phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (206 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: txy:Thexy_1470 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (260 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa) |
| | Tsac_2014 | KEGG: txy:Thexy_1472 glutamine amidotransferase of anthranilate synthase; TIGRFAM: Glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I, C-terminal. (195 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (474 aa) |
| | Tsac_2019 | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (234 aa) |
| | Tsac_2138 | KEGG: txy:Thexy_1592 GTP-binding protein TypA; TIGRFAM: GTP-binding protein TypA; Small GTP-binding protein; PFAM: Protein synthesis factor, GTP-binding; Translation elongation factor EFTu/EF1A, domain 2; Translation elongation factor EFG/EF2, C-terminal. (607 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (348 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (366 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (124 aa) |
| | gcvPA | Glycine dehydrogenase (decarboxylating) subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (451 aa) |
| | gcvPB | Glycine dehydrogenase (decarboxylating) subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (483 aa) |
| | Tsac_2347 | KEGG: txy:Thexy_0914 dihydrolipoamide dehydrogenase; TIGRFAM: Dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Biotin/lipoyl attachment; Pyridine nucleotide-disulphide oxidoreductase, dimerisation. (554 aa) |
| | Tsac_2377 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: txy:Thexy_0868 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. (154 aa) |
| | Tsac_2465 | KEGG: txy:Thexy_0835 GAF sensor protein; PFAM: GAF; SMART: GAF. (162 aa) |
| | deoD | TIGRFAM: Purine nucleoside phosphorylase; HAMAP: Purine nucleoside phosphorylase deoD-type; KEGG: txy:Thexy_0828 Purine nucleoside phosphorylase DeoD-type; PFAM: Nucleoside phosphorylase. (233 aa) |
| | Tsac_2501 | ATPase AAA; KEGG: txy:Thexy_0799 ATPase AAA. (547 aa) |
| | Tsac_2567 | KEGG: txy:Thexy_0725 hypothetical protein. (80 aa) |
| | metN | ABC transporter related protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (340 aa) |
| | Tsac_2570 | ABC-type transporter, integral membrane subunit; PFAM: Binding-protein-dependent transport systems inner membrane component; KEGG: txy:Thexy_0722 ABC transporter transmembrane protein. (225 aa) |
| | Tsac_2571 | KEGG: txy:Thexy_0721 lipoprotein, YaeC family; TIGRFAM: Lipoprotein YaeC; PFAM: NLPA lipoprotein. (281 aa) |
| | luxS | Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (146 aa) |
| | purD | Phosphoribosylamine--glycine ligase; TIGRFAM: Phosphoribosylglycinamide synthetase; HAMAP: Phosphoribosylglycinamide synthetase; KEGG: txy:Thexy_0715 phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (416 aa) |
| | purH | SMART: AICARFT/IMPCHase bienzyme, formylation region; TIGRFAM: AICARFT/IMPCHase bienzyme; KEGG: txy:Thexy_0714 Bifunctional purine biosynthesis protein PurH; HAMAP: Bifunctional purine biosynthesis protein purH; PFAM: AICARFT/IMPCHase bienzyme, formylation region; MGS-like. (508 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (202 aa) |
| | purM | KEGG: txy:Thexy_0712 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, C-terminal; AIR synthase related protein. (336 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (465 aa) |
| | purC | TIGRFAM: SAICAR synthetase; HAMAP: Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: txy:Thexy_0710 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (235 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa) |
| | Tsac_2584 | PFAM: Xanthine/uracil/vitamin C permease; KEGG: txy:Thexy_0708 xanthine/uracil/vitamin C permease. (482 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (512 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (484 aa) |
| | Tsac_2625 | KEGG: txy:Thexy_0667 carbamate kinase; TIGRFAM: Bacterial carbamate kinase; PFAM: Aspartate/glutamate/uridylate kinase. (314 aa) |
| | Tsac_2626 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (313 aa) |
| | Tsac_2653 | KEGG: txy:Thexy_0652 sulfate ABC transporter ATPase; PFAM: ABC transporter-like; SMART: ATPase, AAA+ type, core. (240 aa) |
| | Tsac_2654 | KEGG: txy:Thexy_0651 polar amino acid ABC transporter, inner membrane subunit; TIGRFAM: Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine; PFAM: Binding-protein-dependent transport systems inner membrane component. (220 aa) |
| | Tsac_2655 | ABC-type transporter, periplasmic subunit family 3; KEGG: txy:Thexy_0650 ABC transporter periplasmic protein; PFAM: Extracellular solute-binding protein, family 3; SMART: Extracellular solute-binding protein, family 3; Ionotropic glutamate receptor. (258 aa) |
